{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:20:19Z","timestamp":1771658419966,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anesthesiology Research and Practice"],"published-print":{"date-parts":[[2023,1,20]]},"abstract":"<jats:p>Background. The quality of recovery is a cluster of patient-related outcomes that emphasise not only pain but different physical and emotional dimensions. Traditionally, ketamine is used to improve postoperative analgesia and avoid opioid consumption and opioid-related side effects. Objective. The present study sought to evaluate if intraoperative ketamine administration (as a part of multimodal analgesia) influences the quality of recovery after laparoscopic surgery. Design. A prospective two-armed, single-blinded trial. Settings. Tertiary single-centre trial between July 2021 and January 2022. Patients. From the 146 patients initially admitted to the study, 127 patients were enrolled, 60 in the ketamine group (group K) and 67 in the control group (group NK). Intervention. Both groups received a rigid intraoperative anaesthesia protocol; furthermore, in group K, 0.5\u2009mg\/kg of the ideal body weight of ketamine was administered. Main Outcome Measures. The primary outcome was to evaluate the effect of ketamine administration on the postoperative quality of recovery using the Portuguese version of the Quality of Recovery-15 (QoR-15) Questionnaire 24\u2009h after surgery. The total score and minimal clinically significant difference (MCID) of the QoR-15 were compared. Other variables were also assessed such as the presence of emergence delirium (ED), the Numeric Rating Scale (NRS) for pain, and the presence of postoperative nausea and vomiting (PONV). Results. A total of 127 patients were allocated to the study groups, 60 in group K and 67 in group NK. Regarding the primary outcome, no differences were found in individual categories (15 items) and in the total score of QoR-15 (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.214<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Concerning improvement (MCID\u2009\u2265\u20098) or worsening (MCID\u2009\u2264\u20098) in quality of recovery, no difference was found between the groups (24 vs. 32 and 6 vs. 6; <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.776<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Finally, no difference was found in secondary postoperative outcomes including ED (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.55<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), NRS (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.401<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>), and PONV (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.55<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Conclusion. In this study, the administration of ketamine in laparoscopic surgery had no impact on the quality of recovery 24\u2009h after surgery. This trial is registered with NCT03724019.<\/jats:p>","DOI":"10.1155\/2023\/8890025","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T23:05:06Z","timestamp":1674255906000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Ketamine on Quality of Recovery after Laparoscopic Surgery: A Single-Centre Single-Blinded Trial Using the QoR-15 Questionnaire"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-8093","authenticated-orcid":true,"given":"Helder","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology-Faculty of Medicine, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"},{"name":"Anaesthesia Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-9216","authenticated-orcid":true,"given":"Maria In\u00eas","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"Anaesthesia Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-3631","authenticated-orcid":true,"given":"Diana","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Anaesthesia Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-8628","authenticated-orcid":true,"given":"Alfredo","family":"Mendes-Castro","sequence":"additional","affiliation":[{"name":"Anaesthesia Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"},{"name":"Department of Community Medicine, Information and Health Decision Sciences-Faculty of Medicine, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-2908","authenticated-orcid":true,"given":"Fernando","family":"Abelha","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology-Faculty of Medicine, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"},{"name":"Anaesthesia Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2018.07.002"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318289b84b"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev413"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.20344\/amp.6129"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000001158"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/aco.0000000000000916"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.15010"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.033"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1213\/01.Ane.0000105911.66089.59"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12377"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2022.04.028"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12919"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/01.Cir.100.10.1043"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.185699"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2012.09.003"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000265534.73169.95"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/aco.0000000000000612"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13168"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)31467-8"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2022.10.002"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00921"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1213\/01.Ane.0000137441.79168.C5"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012033.pub4"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0383-6"}],"container-title":["Anesthesiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/arp\/2023\/8890025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/arp\/2023\/8890025.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/arp\/2023\/8890025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T23:05:09Z","timestamp":1674255909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/arp\/2023\/8890025\/"}},"subtitle":[],"editor":[{"given":"Ronald G.","family":"Pearl","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":24,"alternative-id":["8890025","8890025"],"URL":"https:\/\/doi.org\/10.1155\/2023\/8890025","relation":{},"ISSN":["1687-6970","1687-6962"],"issn-type":[{"value":"1687-6970","type":"electronic"},{"value":"1687-6962","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,20]]}}}