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GBM patients\u2019 methylation and gene expression data along with clinical information from TCGA were retrieved. The most overrepresented pathways were identified independently for each omics dataset. From the genes found in at least 30% of these pathways, one gene that was identified in both sets was further examined using the Kaplan-Meier method for survival analysis. Additionally, three groups of patients who started radio and chemotherapy at different times were identified, and the influence of these variations in treatment modality on patient survival was evaluated. Four pathways that seemed to negatively impact survival and two with the opposite effect were identified. The methylation status of PRKCB was highlighted as a potential novel biomarker for patient survival. The study also found that treatment with chemotherapy prior to radiotherapy can have a significant impact on patient survival, which could lead to improvements in clinical management and therapeutic approaches for GBM patients.<\/jats:p>","DOI":"10.1155\/2024\/5582424","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T22:20:05Z","timestamp":1712269205000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Novel Molecular and Clinical Biomarkers of Survival in Glioblastoma Multiforme Patients: A Study Based on The Cancer Genome Atlas Data"],"prefix":"10.1155","volume":"2024","author":[{"given":"Lu\u00edsa","family":"Esteves","sequence":"first","affiliation":[{"name":"Cytogenetics and Genomics Laboratory, Institute of Cellular and Molecular Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal"}]},{"given":"Francisco","family":"Caramelo","sequence":"additional","affiliation":[{"name":"University of 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