{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:58:36Z","timestamp":1790413116240,"version":"4.1.0"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["UID127492"],"award-info":[{"award-number":["UID127492"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031448","name":"University of Cape Coast","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Treatment"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    People living with HIV (PLHIV) are at increased risk of liver and kidney dysfunction due to chronic HIV infection, long\u2010term antiretroviral therapy (ART), and persistent immune activation. However, age\u2010related differences in organ function and treatment outcomes remain insufficiently characterized in African settings. This study aimed to assess age\u2010related differences in liver and renal function among PLHIV in Ghana to identify patterns of organ dysfunction across different age groups. This multicenter cross\u2010sectional study included 558 PLHIV aged 10\u201376\u2009years receiving ART, of whom 96.4% were on dolutegravir\u2010based regimens. Renal function was assessed using serum urea, creatinine, urea\u2010to\u2010creatinine ratio, and estimated glomerular filtration rate (eGFR). Liver function was assessed using AST\/ALT ratios, hepatotoxicity grading, and fibrosis indices (APRI, FIB\u20104), while virologic outcomes were assessed using HIV viral load measurements. A composite renal\u2013hepatic\u2013virologic abnormality score was developed based on reduced kidney function (eGFR\u2009&lt;\u200960\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    ), elevated AST\/ALT ratio (&gt;\u20091), and unsuppressed viral load (\u2265\u20091000 copies\/mL). Data were analyzed using STATA, with\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05 considered statistically significant. Renal, hepatic, and virologic parameters showed significant variation across age groups. Older participants, particularly those aged \u2265\u200960\u2009years, had lower mean eGFR values (60.32\u2009\u00b1\u200917.17\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    ;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), while adolescents aged 13\u201319\u2009years had the highest frequency of virological failure (22.22%;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). The composite renal\u2013hepatic\u2013virologic abnormality score differed significantly across age groups (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), with adolescents aged 13\u201319\u2009years having higher odds of a greater abnormality score compared with children aged \u2264\u200912\u2009years (aOR\u2009=\u20093.15, 95% CI: 1.23\u20138.08;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.017). In conclusion, age\u2010related differences were observed in renal, hepatic, and virologic abnormalities among PLHIV in Ghana. These findings support the need for age\u2010tailored biochemical monitoring and further longitudinal studies to clarify temporal relationships between aging and organ function in PLHIV.\n                  <\/jats:p>","DOI":"10.1155\/arat\/1670270","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:13:51Z","timestamp":1790410431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Related Variations in Clinical and Biochemical Profiles of People Living With HIV"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1884-0852","authenticated-orcid":false,"given":"Oksana","family":"Ryabinina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1594-4193","authenticated-orcid":false,"given":"Joel Adu","family":"Twum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0194-7128","authenticated-orcid":false,"given":"John","family":"Anyimadu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1768-4662","authenticated-orcid":false,"given":"Hilary Kenneth","family":"Addison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5726-7894","authenticated-orcid":false,"given":"Paul Jerrod","family":"Amoako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-7544","authenticated-orcid":false,"given":"Samuel 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