{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:40:00Z","timestamp":1792352400381,"version":"4.4.0"},"reference-count":74,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":290,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Myocardial angiogenesis contributes to the maintenance of myocardial perfusion and cardiac function. Resistance training (RT) induces cardiovascular adaptations, but the myocardial transcriptional responses to acute RT (ART) and chronic RT (CRT) remain incompletely understood. This study compared the expression of angiogenesis\u2010 and metabolic adaptation\u2013related genes in the left ventricle following a single RT bout and 8\u2009weeks of repeated RT in healthy male Wistar rats. Twenty\u2010four rats were randomized to three groups: sedentary control (CON) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098), ART (one ladder\u2010climbing session), or CRT (ladder\u2010climbing 5\u2009days\/week for 8\u2009weeks). RT was performed on a 1\u2010m ladder inclined at 80\u00b0 using progressive loads attached to the tail. Left\u2010ventricular tissue was collected 1\u2009h after the exercise bout in ART and 1\u2009h after the final training session in CRT. Compared to CON, ART showed significantly higher HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and FSTL1 expression, whereas PGC\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and VEGF did not differ significantly. CRT also showed significantly higher HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and FSTL1 expression than CON, together with significantly higher PGC\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and VEGF expression. No significant differences were observed between ART and CRT for any of the genes examined. These findings demonstrate distinct myocardial transcriptional profiles following ART versus CRT, characterized by an HIF\u20101\u03b1\u2010 and FSTL1\u2010associated response after a single bout and a PGC\u20101\u03b1\u2010 and VEGF\u2010associated response following CRT.\n                  <\/jats:p>","DOI":"10.1155\/crp\/2976039","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:02:32Z","timestamp":1792350152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute and Chronic Resistance Training Differentially Modulate Myocardial Angiogenesis\u2013Related Gene Expression in Wistar Rats"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-9156","authenticated-orcid":false,"given":"Putri","family":"Karisa","sequence":"first","affiliation":[{"name":"Faculty of Medicine Padjadjaran University  Bandung 40161 West Java Indonesia  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