{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:19:34Z","timestamp":1772986774545,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":102,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81X1600211"],"award-info":[{"award-number":["81X1600211"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["413635475"],"award-info":[{"award-number":["413635475"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Long\u2010COVID has attracted increased attention with rising numbers of affected patients and high individual symptom burden. Prior studies have described its prevalence, course of disease, and severity. Yet, the influence of intensive care, including telemedical support for patients at risk for a severe course of the initial COVID\u201019 disease, on the occurrence of Long\u2010COVID and its associated symptoms is studied to a lesser extent.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Here, we report the long\u2010term results of the COVID\u2010SMART study, which randomized at\u2010risk COVID\u201019 patients to either smartwatch\u2010based monitoring with telemedical support or standard care. We investigate Long\u2010COVID symptoms, including symptoms of depression and anxiety after 12 months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Findings:<\/jats:bold>\n                    Between October 2020 and May 2022, we enrolled 607 patients in the COVID\u2010SMART study. Complete 12\u2010month follow\u2010up was available for 573 patients, with 288 patients randomized to the intervention group and 285 to the control group. Overall, 234 participants (40.8%) reported COVID\u2010related symptoms, with a high prevalence of symptoms of depression (209 participants, 36.5%) and anxiety (232 participants, 40.5%). However, telemedical support did not reduce these symptoms at follow\u2010up. Multivariable regression analysis identified sex, active smoking, and pre\u2010existing asthma as significant predictors of both outcomes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Interpretation:<\/jats:bold>\n                    COVID\u2010SMART is the first prospective, randomized clinical trial to systematically assess the impact of telemedical care on the development of Long\u2010COVID associated risk of depression and anxiety. We identify in part modifiable risk factors for these outcomes. However, telemedical support does not appear to be beneficial in reducing symptoms of anxiety and depression and should hence be focused to the acute infection phase.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT04471636\n                  <\/jats:p>","DOI":"10.1155\/da\/9989990","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T02:26:56Z","timestamp":1744597616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptoms of Depression and Anxiety After COVID\u201019 Despite Systematic Telemedical Care: Results From the Prospective COVID\u2010SMART Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-3016","authenticated-orcid":false,"given":"Aenne S.","family":"von Falkenhausen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Gail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Geipel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-6793","authenticated-orcid":false,"given":"Clemens","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Stockhausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-9445","authenticated-orcid":false,"given":"Lauren E.","family":"Sams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Massberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-3581","authenticated-orcid":false,"given":"Stefan","family":"K\u00e4\u00e4b","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-796X","authenticated-orcid":false,"given":"Moritz F.","family":"Sinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,13]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-020-02796-2"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac031"},{"key":"e_1_2_11_3_2","unstructured":"National Institute for Health and Care Excellence COVID-19 Rapid Guideline: Managing the Long-Term Effects of COVID-19 2024 National Institute for Health and Care Excellence London."},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3489"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01283-z"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01292-y"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00383-0"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2021.100122"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249644"},{"key":"e_1_2_11_10_2","doi-asserted-by":"crossref","unstructured":"WentzE. 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