{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:40:46Z","timestamp":1792395646548,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":290,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Analytical Chemistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Reynoutria multiflora<\/jats:italic>\n                    (Thunb.) Moldenke is a commonly used herbal drug in traditional Chinese medicine. Prior literature has indicated that\n                    <jats:italic>R. multiflora<\/jats:italic>\n                    possesses broadband pharmacological activities. According to Taiwan Herbal Pharmacopeia (IV) and previous reports, the dominant components of\n                    <jats:italic>R. multiflora<\/jats:italic>\n                    were 2,3,5,4\u2032\u2010tetrahydroxystilbene\u20102\u2010O\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010D\u2010glucopyranoside (THSG) (\n                    <jats:bold>1<\/jats:bold>\n                    ) and free anthraquinones such as emodin (\n                    <jats:bold>2<\/jats:bold>\n                    ), physcion (\n                    <jats:bold>3<\/jats:bold>\n                    ), and rhein (\n                    <jats:bold>4<\/jats:bold>\n                    ), which played pivotal roles in the pharmacological effects of herbs. However, the standard analytic method with HPLC\u2010UV took much time to prepare samples and calibration curves based on the standard substances. In this study, a rapid quantitative\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR analytic method has been developed, which can quantify the indicator compounds in\n                    <jats:italic>R. multiflora<\/jats:italic>\n                    samples. The method validation data demonstrated the good accuracy and precision of this qNMR method. The feasible analytical method can monitor the contents of indicator compounds in both raw and processed herbs. In addition, this method could be applied to analyze the indicator compounds in the decoction Qi Bao Mei Ran Dan successfully. These results all supported the proposed method as a useful tool for quality control of\n                    <jats:italic>R. multiflora<\/jats:italic>\n                    herbal materials and decoctions. With further refinement, this method could serve as a reference for future standard methods in pharmacopoeias.\n                  <\/jats:p>","DOI":"10.1155\/ianc\/6092060","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:53:21Z","timestamp":1792392801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Feasible\n                    <sup>1<\/sup>\n                    H\u2010NMR Quantification Method of Indicator Compounds in Microwave\u2010Processed\n                    <i>Reynoutria multiflora<\/i>\n                    Radix and Its Decoction"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4929-9898","authenticated-orcid":false,"given":"Hao-Ze","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan 70101 Taiwan  ncku.edu.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Nhung","family":"Phan","sequence":"additional","affiliation":[{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan 70101 Taiwan  ncku.edu.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zih-Hong","family":"Jhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan 70101 Taiwan  ncku.edu.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Chung-Hsing University  Taichung 402 Taiwan  nchu.edu.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan 70101 Taiwan  ncku.edu.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Shung","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan 70101 Taiwan  ncku.edu.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-1138","authenticated-orcid":false,"given":"Ping-Chung","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Pharmacy College of Medicine National Cheng Kung University  Tainan 70101 Taiwan  ncku.edu.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250132"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2025.128708"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2024.2406990"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c07092"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/d5ay01340b"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2023.2219819"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2025.5078"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-025-01477-3"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.210483"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2026.116121"},{"key":"e_1_2_12_11_2","volume-title":"Taiwan Herbal Pharmacopeia","author":"Editorial Member of Taiwan Herbal Pharmacopeia","year":"2022"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12110729"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113864"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.11.009"},{"key":"e_1_2_12_15_2","doi-asserted-by":"crossref","unstructured":"LeiX. 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