{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T13:39:39Z","timestamp":1792935579188,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:00:00Z","timestamp":1792886400000},"content-version":"vor","delay-in-days":297,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Boron trichloride (BCl\n                    <jats:sub>3<\/jats:sub>\n                    ) is highly reactive and degrades rapidly when exposed to moisture, complicating analyses, and posing safety risks under standard laboratory conditions. To address these challenges, quantitative\n                    <jats:sup>11<\/jats:sup>\n                    B nuclear magnetic resonance (qNMR) spectroscopy has been introduced as an analytical method to accurately quantitate boron trichloride in solution. This technique involves the reaction of boron trichloride with methanol to produce trimethyl borate, which is then quantified using an external standard. The preparation process allows for the reaction and sample preparation to occur in a single step within the same vial, ensuring a safe, fast, and reliable analysis. The\n                    <jats:sup>11<\/jats:sup>\n                    B qNMR method was validated, demonstrating linearity (0.02\u2009M to 0.50\u2009M with\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.9999), accuracy (recovery of 100.05%), precision (inter\u2010 and intraday), stability, and robustness. This paper highlights the effectiveness of the\n                    <jats:sup>11<\/jats:sup>\n                    B qNMR method for the accurate, reliable, fast, and safe quantification of boron trichloride in organic solvents such as dichloromethane.\n                  <\/jats:p>","DOI":"10.1155\/jamc\/4351793","type":"journal-article","created":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:44:26Z","timestamp":1792932266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Analysis of Boron Trichloride Using\n                    <sup>11<\/sup>\n                    B Quantitative Nuclear Magnetic Resonance Spectroscopy (qNMR)"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0902-6866","authenticated-orcid":false,"given":"Daniel","family":"Van Niekerk","sequence":"first","affiliation":[{"name":"Analytical Development Gilead Sciences  1021 Hayter Road Edmonton T6S 1A1 Alberta Canada  gilead.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3180-6933","authenticated-orcid":false,"given":"Jaspaul","family":"Tatlay","sequence":"additional","affiliation":[{"name":"Analytical Development Gilead Sciences  1021 Hayter Road Edmonton T6S 1A1 Alberta Canada  gilead.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6517-0411","authenticated-orcid":false,"given":"Hilaire V.","family":"Kemami Wangun","sequence":"additional","affiliation":[{"name":"Analytical Development Gilead Sciences  1021 Hayter Road Edmonton T6S 1A1 Alberta Canada  gilead.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4074-2124","authenticated-orcid":false,"given":"Nicholas J.","family":"Morehouse","sequence":"additional","affiliation":[{"name":"Analytical Development Gilead Sciences  1021 Hayter Road Edmonton T6S 1A1 Alberta Canada  gilead.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,25]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr50024a003"},{"key":"e_1_2_11_2_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0022-328X(03)00209-2","article-title":"The Use of Organoboron Chlorides and Bromides in Organic Synthesis","volume":"680","author":"Kabalka G. 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Interaction of Alcohols and Boron Trichloride Journal of the Chemical Society 1951 no. 0 2545\u20132550.","DOI":"10.1039\/jr9510002545"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6py01853j"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1515\/zna-1986-0508"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic50052a026"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.210483"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.01.043"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2436"},{"key":"e_1_2_11_35_2","volume-title":"ICH Harmonised Guideline: Validation of Analytical Procedures","author":"(ICH), I.C.f.H.","year":"2023"}],"container-title":["Journal of Analytical Methods in Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jamc\/4351793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/jamc\/4351793","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/jamc\/4351793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:44:31Z","timestamp":1792932271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/jamc\/4351793"}},"subtitle":[],"editor":[{"given":"Sohini","family":"Basu Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/jamc\/4351793"],"URL":"https:\/\/doi.org\/10.1155\/jamc\/4351793","archive":["Portico"],"relation":{},"ISSN":["2090-8865","2090-8873"],"issn-type":[{"value":"2090-8865","type":"print"},{"value":"2090-8873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4351793"}}