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Current scoping reviews systematically map and synthesize the existing literature on supercentenarians and semisuper centenarians to identify key themes, methodologies, and findings that can inform the development of a comprehensive framework for a Global Supercentenarian Cohort Study protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scoping review was conducted as per PRISMA\u2010ScR guidelines using the PEO framework (population: semisupercentenarians aged 105+; exposure: genetics, socioecological, and other factors; outcome: supercentenarians aged 110+). Seven databases, Scopus, ProQuest, PubMed, PsycINFO, Scopus Secondary literature, Scopus Patents, and Cochrane Database of Systematic Reviews (CDSR), were searched, incorporating data from Scopus Secondary literature. Unpublished data were excluded. The scoping review protocol was published to ensure transparency and rigor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Discussion<\/jats:title>\n                    <jats:p>144 were included. A thematic analysis of individual studies\u2032 findings was conducted to identify multidimensional themes of supercentenarian health. The following themes were identified: Age validation theme, demographics theme, behavior theme, personality, traits theme, quality of life theme, well\u2010being and life satisfaction, cognition theme, social theme, religiosity\/spirituality theme, independence\/self\u2010ability theme, mental health theme, health theme, genetics theme, and ecological theme. There was variability in the methods of assessment and tools used for each theme across different studies and inconsistencies in terminology, with similar concepts such as social support, social engagement, social contact, and social isolation being referred to by different names in various studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We propose a comprehensive framework comprising three components: cohort setting, measuring contributing factors, and full assessment. This framework sets the stage for a unified, supranational protocol that harmonizes survey methods across countries, integrates multidisciplinary perspectives, and adopts a longitudinal approach. It would enable larger sample sizes and more robust statistical analyses, allowing researchers to explore complex relationships and derive more accurate conclusions about supercentenarians\u2032 health, well\u2010being, and longevity. 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