{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:02:38Z","timestamp":1787241758723,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Cl\u00ednica Espa\u00f1ola"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1157\/13090481","type":"journal-article","created":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T06:41:11Z","timestamp":1152600071000},"page":"332-335","source":"Crossref","is-referenced-by-count":4,"title":["Manifestaciones cl\u00ednicas y retraso diagn\u00f3stico en el s\u00edndrome de Wolfram"],"prefix":"10.1016","volume":"206","author":[{"given":"G.","family":"Esteban Bueno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"G\u00f3mez Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1157\/13090481_bib1","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0140-6736(95)92473-6","article-title":"Neurodegeneration and diabetes; UK Nationwide Study of Wolfram (DIDMOAD) syndrome","volume":"346","author":"Barrett","year":"1995","journal-title":"Lancet"},{"issue":"8","key":"10.1157\/13090481_bib2","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.2337\/diacare.27.8.2003","article-title":"Phenotype-genotype correlations in a series of wolfram syndrome families","volume":"27","author":"Smith","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1157\/13090481_bib3","first-page":"510","article-title":"Neurodegenerative disorders associated with diabetes mellitus","volume":"82I 8","author":"Ristow","year":"2004","journal-title":"J Mol Med"},{"issue":"16","key":"10.1157\/13090481_bib4","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/hmg\/ddg214","article-title":"Wolfram syndrome: structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product","volume":"12","author":"Hoffmann","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1157\/13090481_bib5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/humu.1110","article-title":"WFS1\/wolframin mutations, Wolfram syndrome, and associated diseases","volume":"17","author":"Khanim","year":"2001","journal-title":"Hum Mutat"},{"issue":"12","key":"10.1157\/13090481_bib6","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.2337\/diacare.18.12.1566","article-title":"Morbility and mortality in Wolfram syndrome","volume":"18","author":"Kinsley","year":"1995","journal-title":"Diabetes Care"},{"key":"10.1157\/13090481_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1651-2227.1977.tb15069.x","article-title":"Juvenile DM, optic atrophy, hearing loss, diabetes insipidus, atonia of the urinary tract and bladder, and other abnormalities (Wolfram syndrome). Review of 88 cases from the literature with personal observations on 3 patients","volume":"264","author":"Cremers","year":"1977","journal-title":"Acta P\u00e6diatr Scand Suppl"},{"key":"10.1157\/13090481_bib8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF01720362","article-title":"The syndrome of diabetes insipidus, DM, optic atrophy, deafness, and other abnormalities (DIDMOAD-syndrome). Two affected sibs and short review of literature (98 cases)","volume":"60","author":"Dreyer","year":"1982","journal-title":"Klin Wochenschr"},{"issue":"2","key":"10.1157\/13090481_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijporl.2003.10.012","article-title":"Wolfram syndrome","volume":"68","author":"Megighian","year":"2004","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"10.1157\/13090481_bib10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1651-2227.1988.tb10669.x","article-title":"Contrasting features of insulin dependent DM associated with neuroectodermal defects and classical insulin dependent DM","volume":"77","author":"Garc\u00eda Luna","year":"1988","journal-title":"Acta Paediatr Scand"},{"issue":"8","key":"10.1157\/13090481_bib11","first-page":"418","article-title":"Descripci\u00f3n del s\u00edndrome de Wolfram (DIDMOAD) a partir de un nuevo caso","volume":"184","author":"Bernab\u00e9u Mor\u00f3n","year":"1989","journal-title":"Rev Clin Esp"},{"key":"10.1157\/13090481_bib12","first-page":"20","article-title":"Alteraciones urol\u00f3gicas en el s\u00edndrome de Wolfram. Estudio de dos casos en una misma familia","volume":"1","author":"Pereira Garc\u00eda","year":"1989","journal-title":"Urodin\u00e1mica Aplicada"},{"issue":"3","key":"10.1157\/13090481_bib13","first-page":"135","article-title":"Un caso de s\u00edndrome de DIDMOAD con afectaci\u00f3n urol\u00f3gica","volume":"8","author":"Gonz\u00e1lez Sarmiento","year":"1991","journal-title":"An Med Interna"},{"issue":"1","key":"10.1157\/13090481_bib14","first-page":"26","article-title":"Neurologic manifestations in Wolfram\u2019s syndrome","volume":"149","author":"Leiva-Santana","year":"1993","journal-title":"Rev Neurol"},{"issue":"5","key":"10.1157\/13090481_bib15","first-page":"963","article-title":"Autosomal recessive Wolfram syndrome associated with an 8.5-kb mtDNA single deletion","volume":"58","author":"Barrientos","year":"1996","journal-title":"Am J Hum Genet"},{"issue":"7","key":"10.1157\/13090481_bib16","first-page":"871","article-title":"Uro-andrologic alterations in Wolfram syndrome","volume":"44","author":"Fern\u00e1ndez Rodr\u00edguez","year":"1991","journal-title":"Arch Esp Urol"},{"issue":"10","key":"10.1157\/13090481_bib17","first-page":"795","article-title":"Wolfram syndrome or DIDMOAD syndrome","volume":"40","author":"Sarria","year":"1983","journal-title":"Arch Fr Pediatr"},{"issue":"5","key":"10.1157\/13090481_bib18","first-page":"474","article-title":"Urologic manifestations in Wolfram\u2019s syndrome","volume":"20","author":"Monllor Gisbert","year":"1996","journal-title":"Actas Urol Esp"},{"issue":"8","key":"10.1157\/13090481_bib19","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.2337\/diacare.22.8.1378","article-title":"Partial Wolfram syndrome (DIDMOAD): two new patients in a family. Diabetes insipidus, diabetes mellitus, optic atrophy, and deafness","volume":"22","author":"Hern\u00e1ndez-Mijares","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1157\/13090481_bib20","series-title":"Insulin- receptor interaction in DM-optic atrophy syndrome. 2nd International symposium on insulin receptors","author":"Dur\u00e1n Garc\u00eda","year":"1983"},{"issue":"6","key":"10.1157\/13090481_bib21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0210-4806(00)72493-4","article-title":"Wolfram syndrome. Urologic implications","volume":"24","author":"Anglada Curado","year":"2000","journal-title":"Actas Urol Esp"}],"container-title":["Revista Cl\u00ednica Espa\u00f1ola"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014256506728144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014256506728144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:51:06Z","timestamp":1547513466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014256506728144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0014256506728144"],"URL":"https:\/\/doi.org\/10.1157\/13090481","relation":{},"ISSN":["0014-2565"],"issn-type":[{"value":"0014-2565","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}