{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:49:29Z","timestamp":1777463369615,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterolog\u00eda y Hepatolog\u00eda"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1157\/13094348","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T13:55:26Z","timestamp":1163685326000},"page":"534-541","source":"Crossref","is-referenced-by-count":2,"title":["Terapia de combinaci\u00f3n secuencial con prednisona, lamivudina e interfer\u00f3n alfa-2b en pacientes con hepatitis cr\u00f3nica B y ant\u00edgeno e positivo"],"prefix":"10.1016","volume":"29","author":[{"given":"Eduardo","family":"Vilar G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bienvenido","family":"Gr\u00e1 Oramas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Ar\u00fas Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caridad","family":"Ruenes Domech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudith","family":"D\u00e1vila Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1157\/13094348_bib1","doi-asserted-by":"crossref","first-page":"90S","DOI":"10.1016\/S0168-8278(02)00431-2","article-title":"Management of chronic hepatitis B","volume":"38","author":"Conjeevaram","year":"2003","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib2","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/S0140-6736(03)15108-2","article-title":"Viral hepatitis B","volume":"362","author":"Lai","year":"2003","journal-title":"Lancet"},{"key":"10.1157\/13094348_bib3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/hep.20110","article-title":"AASLD practice guideline: chronic hepatitis B update of recommendations","volume":"39","author":"Lok","year":"2004","journal-title":"Hepatology"},{"key":"10.1157\/13094348_bib4","doi-asserted-by":"crossref","first-page":"125S","DOI":"10.1016\/S0168-8278(03)00155-7","article-title":"Results of lamivudine in Asian trials","volume":"39","author":"Liaw","year":"2003","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib5","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1056\/NEJMoa020681","article-title":"Adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B","volume":"348","author":"Marcellin","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1157\/13094348_bib6","doi-asserted-by":"crossref","first-page":"146S","DOI":"10.1016\/S0168-8278(03)00352-0","article-title":"Combination therapy for chronic hepatitis B","volume":"39","author":"Schalm","year":"2003","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib7","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/hep.1840200603","article-title":"Prednisone-interferon combination in the treatment of chronic hepatitis B: direct and indirect meta-analysis","volume":"20","author":"Cohard","year":"1994","journal-title":"Hepatology"},{"key":"10.1157\/13094348_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1053\/jhep.2000.9717","article-title":"Prednisolone priming enhances Th 1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B","volume":"32","author":"Liaw","year":"2002","journal-title":"Hepatology"},{"key":"10.1157\/13094348_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1056\/NEJM199008023230503","article-title":"A ramdomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B","volume":"323","author":"Perrillo","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1157\/13094348_bib10","unstructured":"Common toxicity criteria, version 2. Bethesda. National Cancer Institute, 1999 [citado 15 Dic 2004]. Disponible en: http:\/\/ctep.info.nih.gov"},{"key":"10.1157\/13094348_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0168-8278(03)00083-7","article-title":"EASL international consensus conference on hepatitis B. Consensus statement (Short version)","volume":"38","year":"2003","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib12","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1046\/j.1365-2893.2003.00450.x","article-title":"Peginterferon alfa-2a (40 kDa): an advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B","volume":"10","author":"Cooksley","year":"2003","journal-title":"J Viral Hepatitis"},{"key":"10.1157\/13094348_bib13","doi-asserted-by":"crossref","unstructured":"Marcellin P, Lau GK, Bonino F, et al. A phase III, partially double-blind study evaluating the efficacy and safety of peginterferon alfa-2a (40 kD) alone or in combination with lamivudine vs lamivudine in 537 patients with HBeAg-negative\/anti- HBe-positive chronic hepatitis B. Programs and abstracts from the 55th Annual Meeting of the American Association for the Study of the Liver Diseases. Boston (Massachusetts), del 29 de octubre al 2 de noviembre de 2004.","DOI":"10.1016\/S0270-9139(03)81219-3"},{"key":"10.1157\/13094348_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0168-8278(05)80052-2","article-title":"Does corticosteroid pretreatment enhance the effect of alpha interferon treatment in chronic hepatitis B","volume":"20","author":"Krogsgaard","year":"1994","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib15","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0168-8278(96)80282-0","article-title":"Prednisolone withdrawal therapy enhances the effect of human lymphoblastoid interferon in chronic hepatitis B","volume":"25","author":"Krogsgaard","year":"1996","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/hep.510300313","article-title":"Pretherapy alanine transaminasa level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B","volume":"30","author":"Chien","year":"1999","journal-title":"Hepatology"},{"key":"10.1157\/13094348_bib17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0168-8278(03)00394-5","article-title":"Long-term additional lamivudine therapy enhaces durability of Lamivudine-induced HBeAg loss: a prospective study","volume":"39","author":"Ryu","year":"2003","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1136\/gut.46.4.562","article-title":"Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial","volume":"46","author":"Schalm","year":"2000","journal-title":"Gut"},{"key":"10.1157\/13094348_bib19","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0168-8278(03)00076-X","article-title":"Lamivudine and 24 weeks of lamivudine\/interferon combination therapy for hepatitis B e antigen-positive chronic hepatitis B in interferon nonresponders","volume":"38","author":"Schiff","year":"2003","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0168-8278(01)00145-3","article-title":"Long-term efficacy of interferon alpha-2b and lamivudine in combination compared to lamivudine monotherapy in patients with chronic hepatitis B. An Italian multicenter randomized trial","volume":"35","author":"Barbaro","year":"2001","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib21","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0168-8278(02)00056-9","article-title":"Lamivudine\/interferon combination therapy in anti-HBe positive chronic hepatitis B: a controlled pilot study","volume":"36","author":"Santantonio","year":"2002","journal-title":"J Hepatol"},{"key":"10.1157\/13094348_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0168-8278(05)80055-8","article-title":"Beneficial effect of prednisolone withdrawal followed by lymphoblastoid interferon on the treatment of chronic type B hepatitis in Asians: a randomized controlled trial","volume":"20","author":"Liaw","year":"1994","journal-title":"Hepatology"},{"key":"10.1157\/13094348_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/hep.1840160104","article-title":"Glucocorticoid stimulates hepatitis B viral gene expression in cultured human hepatoma cells","volume":"16","author":"Chau","year":"1992","journal-title":"Hepatology"},{"key":"10.1157\/13094348_bib24","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1073\/pnas.83.6.1627","article-title":"Hepatitis B virus DNA contains a glucocorticoid: responsive element","volume":"83","author":"Tur-Kaspa","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1157\/13094348_bib25","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1056\/NEJMoa013215","article-title":"Hepatitis B e antigen and the risk of hepatocellular carcinoma","volume":"347","author":"Yang","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1157\/13094348_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJM199807093390201","article-title":"A one-year trial of lamivudine of chronic hepatitis B","volume":"339","author":"Lai","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1157\/13094348_bib27","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1056\/NEJM199910213411702","article-title":"Lamivudine as initial treatment for chronic hepatitis B in United States","volume":"341","author":"Dienstag","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1157\/13094348_bib28","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"}],"container-title":["Gastroenterolog\u00eda y Hepatolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210570506716867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210570506716867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T18:51:49Z","timestamp":1683658309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0210570506716867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0210570506716867"],"URL":"https:\/\/doi.org\/10.1157\/13094348","relation":{},"ISSN":["0210-5705"],"issn-type":[{"value":"0210-5705","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}