{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:36:16Z","timestamp":1787106976549,"version":"build-2736575974"},"reference-count":16,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":7111,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1157\/13099694","type":"journal-article","created":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T07:52:05Z","timestamp":1174290725000},"page":"305-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["D\u00e9ficit de expresi\u00f3n de mol\u00e9culas de clase II del complejo mayor de histocompatibilidad"],"prefix":"10.1016","volume":"66","author":[{"given":"M.\u00aaM.","family":"Serrano-Mart\u00edn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Moreno-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jurado-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1157\/13099694_bib1","series-title":"Immunologic disorders in infants and children","first-page":"447","article-title":"Combined immunodeficiencies","author":"Fisher","year":"2004"},{"key":"10.1157\/13099694_bib2","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0929-693X(99)80005-0","article-title":"D\u00e9ficit immunitaire primitive par d\u00e9faut d\u2019expression des antigens HLA de classe II: neuf observations tunisiennes","volume":"5","author":"Bejaoui","year":"1998","journal-title":"Arch P\u00e9diatr"},{"key":"10.1157\/13099694_bib3","unstructured":"European Society for Immunodeficiencies (ESID) Registry. Disponible en: www.cbt.ki.se\/esid\/registry.html"},{"key":"10.1157\/13099694_bib4","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0090-1229(79)90094-1","article-title":"Failure of lymphocyte membrane HLA A and B expression in two siblings with combined immunodeficiency","volume":"14","author":"Schuurman","year":"1979","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1157\/13099694_bib5","first-page":"87","article-title":"Combined immunodeficiency with defective expression of HLA: Modulation of an abnormal HLA synthesis and functional studies","volume":"19","author":"Lisowska-Grospierre","year":"1983","journal-title":"Birth Defects"},{"key":"10.1157\/13099694_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(78)80598-8","article-title":"Combined immunodeficiency disease associated with absence of cell surface HLA A and B antigen","volume":"93","author":"Touraine","year":"1978","journal-title":"J Pediatr"},{"key":"10.1157\/13099694_bib7","unstructured":"Registro Espa\u00f1ol de Inmunodeficiencias Primarias (REDIP). Disponible en: http:\/\/web.hsd.es\/redip\/"},{"key":"10.1157\/13099694_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0301-0546(01)79030-1","article-title":"Tratamiento sustitutivo con progenitores hematopoy\u00e9ticos en las inmunodeficiencias primarias","volume":"29","author":"Espa\u00f1ol","year":"2001","journal-title":"Allergol Immunopathol"},{"key":"10.1157\/13099694_bib9","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1056\/NEJM199709113371104","article-title":"Mutation of RFXAP, a regulator of MHC class II genes, in primary MHC class II deficiency","volume":"337","author":"Villard","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1157\/13099694_bib10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.immunol.19.1.331","article-title":"The bare lymphocyte syndrome and the regulation of MHC expression","volume":"19","author":"Reith","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1157\/13099694_bib11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1084\/jem.183.3.1063","article-title":"Genetic evidence for a nex type of major histocompatibility complex class II combined immunodeficiency characterized by a discoordinated regulation of HLA-D alpha and beta chains","volume":"183","author":"Douhan","year":"1996","journal-title":"J Exp Med"},{"key":"10.1157\/13099694_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00005792-200111000-00006","article-title":"MHC II deficiency. A disease of gene regulation","volume":"80","author":"Villard","year":"2001","journal-title":"Medicine"},{"key":"10.1157\/13099694_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2249.2003.02110.x","article-title":"Primary Immunodeficiency diseases: an update","volume":"132","author":"Chapel","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1157\/13099694_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.immunol.14.1.301","article-title":"Regulation of MHC class II genes: lessons from a disease","volume":"14","author":"Mach","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1157\/13099694_bib15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0268-960X(96)90008-9","article-title":"Major histocompatibility complex class II deficiency: A clinical review","volume":"10","author":"Elhasid","year":"1996","journal-title":"Blood Rev"},{"key":"10.1157\/13099694_bib16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1182\/blood.V85.2.580.580","article-title":"Bone marrow transplantation in major histocompatibility complex class II deficiency: A single-center study of 19 patients","volume":"85","author":"Klein","year":"1995","journal-title":"Blood"}],"container-title":["Anales de Pediatr\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S169540330770396X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S169540330770396X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:21:49Z","timestamp":1787106109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S169540330770396X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S169540330770396X"],"URL":"https:\/\/doi.org\/10.1157\/13099694","relation":{},"ISSN":["1695-4033"],"issn-type":[{"value":"1695-4033","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"D\u00e9ficit de expresi\u00f3n de mol\u00e9culas de clase II del complejo mayor de histocompatibilidad","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1157\/13099694","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}