{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:28:54Z","timestamp":1776742134749,"version":"3.51.2"},"reference-count":43,"publisher":"Codon Publications","issue":"6","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergologia et Immunopathologia"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1157\/13112991","type":"journal-article","created":{"date-parts":[[2009,1,6]],"date-time":"2009-01-06T17:45:08Z","timestamp":1231263908000},"page":"248-253","source":"Crossref","is-referenced-by-count":47,"title":["Prevalence of symptoms of asthma, rhinitis, and atopic eczema among adolescents living in urban and rural areas in different regions of Brazil"],"prefix":"10.15586","volume":"35","author":[{"given":"D.","family":"Sol\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.E.","family":"Cassol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.P.","family":"Teche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Rizzato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.C.","family":"Bandim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.S.C.","family":"Sarinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.C.","family":"Camelo-Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","reference":[{"key":"10.1157\/13112991_bib1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1651-2227.2002.tb00117.x","article-title":"Does farming provide protection from asthma and allergies?","volume":"91","author":"Brab\u00e4ck","year":"2002","journal-title":"Acta Paediatr"},{"key":"10.1157\/13112991_bib2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"key":"10.1157\/13112991_bib3","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1365-2222.1994.tb01805.x","article-title":"Atopic sensitization and respiratory symptoms among Polish and Swedish school children","volume":"24","author":"Brab\u00e4ck","year":"1994","journal-title":"Clin Exp Allergy"},{"key":"10.1157\/13112991_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1399-3038.1997.tb00147.x","article-title":"Validation of a rhinitis symptom questionnaire (ISAAC core questions) in a population of Swiss school children visiting the school health services. International Study of Asthma and Allergies in Childhood","volume":"8","author":"Braun-Fahrlander","year":"1997","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1157\/13112991_bib5","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1183\/09031936.98.12020432","article-title":"Prevalence of childhood asthma, rhinitis and eczema in Scandinavia and Eastern Europe","volume":"12","author":"Bjorksten","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1157\/13112991_bib6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1258\/0007142001903562","article-title":"The role of environmental factors in asthma","volume":"56","author":"Strachan","year":"2000","journal-title":"Br Med Bull"},{"key":"10.1157\/13112991_bib7","first-page":"260","article-title":"Prevalence of asthma in urban and rural children in Tamil Nadu","volume":"15","author":"Chakravarthy","year":"2002","journal-title":"Natl Med J India"},{"key":"10.1157\/13112991_bib8","first-page":"115","article-title":"Prevalence and asthma risk factors in municipalities of the State of Guerrero","volume":"48","author":"Rojas Molina","year":"2001","journal-title":"Mexico Rev Alerg Mex"},{"key":"10.1157\/13112991_bib9","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/thorax.55.9.775","article-title":"Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia","volume":"55","author":"Hijazi","year":"2000","journal-title":"Thorax"},{"key":"10.1157\/13112991_bib10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3109\/02770900009055459","article-title":"Urbanization and the risk of asthma among schoolchildren in the Palestinian Authority","volume":"37","author":"Hasan","year":"2000","journal-title":"J Asthma"},{"key":"10.1157\/13112991_bib11","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1034\/j.1398-9995.1999.00896.x","article-title":"Allergic disease in teenagers in relation to urban or rural residence at various stages of childhood","volume":"54","author":"Nilsson","year":"1999","journal-title":"Allergy"},{"key":"10.1157\/13112991_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1034\/j.1399-3038.2003.00076.x","article-title":"The hygiene hypothesis","volume":"14","author":"Warner","year":"2003","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1157\/13112991_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-2222.2000.00801.x","article-title":"Reduced risk of hay fever and asthma among children of farmers","volume":"30","author":"Von Ehrenstein","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1157\/13112991_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1399-3038.1991.tb00174.x","article-title":"Urban living as a risk for atopic sensitization in Swedish schoolchildren","volume":"2","author":"Brab\u00e4ck","year":"1991","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1157\/13112991_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(97)01151-3","article-title":"Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia","volume":"350","author":"Yemaneberhan","year":"1997","journal-title":"Lancet"},{"key":"10.1157\/13112991_bib16","doi-asserted-by":"crossref","first-page":"S808","DOI":"10.1016\/S0091-6749(97)80040-1","article-title":"Prevalence of allergic rhinitis in the United States","volume":"99","author":"Nathan","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1157\/13112991_bib17","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1046\/j.1365-2222.2001.01246.x","article-title":"Farming, rural lifestyle and atopy in adults from southern Germany \u2013 results from the MONICA\/KORA study Augsburg","volume":"31","author":"Filipiak","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1157\/13112991_bib18","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1046\/j.1365-2222.2001.01240.x","article-title":"Crete: does farming explain urban and rural differences in atopy?","volume":"31","author":"Barnes","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1157\/13112991_bib19","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1651-2227.2002.tb00122.x","article-title":"Does heredity modify the association between farming and allergy in children?","volume":"91","author":"Remes","year":"2002","journal-title":"Acta Paediatr"},{"key":"10.1157\/13112991_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.1365-2222.2000.00800.x","article-title":"Farm environment in childhood prevents the development of allergies","volume":"30","author":"Kilpelainen","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1157\/13112991_bib21","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1046\/j.1365-2222.2001.01070.x","article-title":"Having lived on a farm and protection against allergic diseases in Australia","volume":"31","author":"Downs","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1157\/13112991_bib22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1590\/S0034-89102004000200020","article-title":"Prevalence of asthma and asthma symptoms among 13 and 14-year-old schoolchildren","volume":"38","author":"Maia","year":"2004","journal-title":"Brazil Rev Saude Publica"},{"key":"10.1157\/13112991_bib23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1590\/S0021-75572006000600006","article-title":"Prevalence of symptoms of asthma, rhinitis, and atopic eczema among Brazilian children and adolescents identified by the International Study of Asthma and Allergies in Childhood (ISAAC) - Phase 3","volume":"82","author":"Sol\u00e9","year":"2006","journal-title":"J Pediatr (Rio J)"},{"key":"10.1157\/13112991_bib24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.95.08030483","article-title":"ISAAC Steering Committee International study of asthma and allergies in childhood (ISAAC): rationale and methods","volume":"8","author":"Asher","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1157\/13112991_bib25","first-page":"10","article-title":"The International Study of Asthma and Allergies in Childhood (ISAAC): phase III rationale and methods","volume":"9","author":"Elwood","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1157\/13112991_bib26","unstructured":"Caruaru, portal da cidade. www.caruaru.pe.gov.br\/dadosgerais.asp - accessed in 07\/09\/2007"},{"key":"10.1157\/13112991_bib27","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (IBGE) \u2013 Popula\u00e7\u00e3o - Indicadores sociais \u2013 Indicadores sociais m\u00ednimos in http:\/\/www.ibge.gov.br\/home\/estatistica\/populacao\/condi-caodevida\/indicadoresminimos\/default_minimos.shtm \u2013 accessed in 07\/09\/2007"},{"key":"10.1157\/13112991_bib28","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (IBGE) \u2013 Defini\u00e7\u00e3o de \u00e1era urbana e rural in http:\/\/www.ibge.gov.br\/home\/estatistica\/populacao\/trabalhoerendimento\/pnad98\/saude\/metodologia.shtm - accessed in 07\/09\/2007"},{"key":"10.1157\/13112991_bib29","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (IBGE)-Popula\u00e7\u00f5es\u2013Crian\u00e7as e adolescentes\u2013 in http:\/\/www.ibge.gov.br\/home\/estatistica\/populacao\/criancas_adolescentes\/default.shtm - accessed in 07\/09\/2007"},{"key":"10.1157\/13112991_bib30","first-page":"34","article-title":"International study of asthma and allergies in childhood (ISAAC): validation of the written questionnaire (eczema component) and prevalence of atopic eczema among Brazilian children","volume":"12","author":"Yamada","year":"2002","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1157\/13112991_bib31","first-page":"376","article-title":"International Study of Asthma and Allergies in Childhood (ISAAC) written questionnaire: validation of the asthma component among Brazilian children","volume":"8","author":"Sol\u00e9","year":"1998","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1157\/13112991_bib32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1034\/j.1399-3038.2001.012002095.x","article-title":"International Study of Asthma and Allergies in Childhood: validation of the rhinitis symptom questionnaire and prevalence of rhinitis in schoolchildren in S\u00e3 Paulo, Brazil","volume":"12","author":"Vanna","year":"2001","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1157\/13112991_bib33","unstructured":"Fletcher RH, Fletcher SW, Wagner EH - Epidemiologia cl\u00ednica: elementos essenciais, 3\u00aa ed, Artes M\u00e9dicas, Porto Alegre, 1996, p. 281."},{"key":"10.1157\/13112991_bib34","unstructured":"Almeida LS, Vilela RB, Soares FJP. Sa\u00fade ind\u00edgena: o caso Xucuru- Kariri in Almeida LS, Vilela RB, Soares FJP (ed) Xucuru-Kariri: Sa\u00fade na Fazenda Canto \u2013 Macei\u00f3, EDUFAL, 2005, pp 9-32."},{"key":"10.1157\/13112991_bib35","unstructured":"Soares FJP, Moreira Jr FJ, Andrade Filho JL, Gameleira KPD, Costa BSM. Preval\u00eancia de asma br\u00f4nquica em crian\u00e7as e adolescentes ind\u00edgenas da tribo Xucuru-Kariri em Palmeira dos \u00cdndios \u2013 AL. In Almeida LS, Vilela RB, Soares FJP (ed) Xucuru-Kariri: Sa\u00fade na Fazenda Canto \u2013 Macei\u00f3, EDUFAL, 2005, pp 119-142."},{"key":"10.1157\/13112991_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2223\/JPED.1024","article-title":"Asthma and ascariasis in children aged two to ten living in a low income suburb","volume":"79","author":"Nascimento Silva","year":"2003","journal-title":"J Pediatr (Rio J)"},{"key":"10.1157\/13112991_bib37","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/oem.2002.006809","article-title":"Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children","volume":"61","author":"Weiland","year":"2004","journal-title":"Occup Environ Med"},{"key":"10.1157\/13112991_bib38","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1081-1206(10)63552-1","article-title":"Effect of animal contact and microbial exposures on the prevalence of atopy and asthma in urban vs rural children in India","volume":"96","author":"Vedanthan","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1157\/13112991_bib39","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJMoa020057","article-title":"Environmental exposure to endotoxin and its relation to asthma in school-age children","volume":"347","author":"Braun-Fahrlander","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1157\/13112991_bib40","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1365-2222.2004.01873.x","article-title":"Determinants of endotoxin levels in living environments of farmers\u2019 children and their peers from rural areas","volume":"34","author":"Waser","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1157\/13112991_bib41","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/annhyg\/mei002","article-title":"Surface sampling for endotoxin assessment using eletrostatic wiping cloths","volume":"49","author":"Thorne","year":"2005","journal-title":"Ann Occup Hyg"},{"key":"10.1157\/13112991_bib42","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.jaci.2007.01.037","article-title":"Not all farming environments protect against the development of asthma and wheeze in children","volume":"119","author":"Ege","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1157\/13112991_bib43","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1164\/rccm.200509-1380OC","article-title":"Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment","volume":"174","author":"Simpson","year":"2006","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Allergologia et Immunopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054607702768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054607702768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:49:29Z","timestamp":1609454969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301054607702768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0301054607702768"],"URL":"https:\/\/doi.org\/10.1157\/13112991","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}