{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T06:17:07Z","timestamp":1738217827926,"version":"3.34.0"},"reference-count":8,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1157\/13116328","type":"journal-article","created":{"date-parts":[[2008,4,22]],"date-time":"2008-04-22T22:08:58Z","timestamp":1208902138000},"page":"199","source":"Crossref","is-referenced-by-count":0,"title":["S\u00edndrome coronario agudo. Hiperhomocisteinemia asociada a mutaci\u00f3n c677t de la metilentetrahidrofolato reductasa y d\u00e9ficit en la anticoagulaci\u00f3n"],"prefix":"10.1016","volume":"130","author":[{"given":"M.","family":"Rosario Ortas Nadal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Mart\u00ednez Moya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Toyas Miazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Ob\u00f3n Azuara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1157\/13116328_bb0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1258\/000456306776865232","article-title":"Hyperhomocysteinaemia, methylenetetrahydrofolate reductase. polymorphism and risk of coronary artery disease","volume":"43","author":"Kerkeni","year":"2006","journal-title":"Ann Clin Biochem"},{"key":"10.1157\/13116328_bb0010","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1590\/S0100-879X2006000400005","article-title":"Hyperhomocystinemia in patients with coronary artery disease","volume":"39","author":"Faria-Neto","year":"2006","journal-title":"Braz J Med Biol Res"},{"key":"10.1157\/13116328_bb0015","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.thromres.2006.06.002","article-title":"Hyperhomocysteinemia is a risk factor of recurrent coronary event in young patients irrespective to the MTHFR C677T polymorphism","volume":"119","author":"Gonz\u00e1lez","year":"2007","journal-title":"Thromb Res"},{"key":"10.1157\/13116328_bb0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in the methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"10.1157\/13116328_bb0025","first-page":"153","article-title":"Prevalencia de la mutaci\u00f3n C677T del gen de la metilentetrahidrofolato reductasa en pacientes con patolog\u00eda isqu\u00e9mica cerebrovascular aguda en la Comunidad Aut\u00f3noma de Arag\u00f3n","volume":"23","author":"S\u00e1nchez","year":"2006","journal-title":"An Med Interna (Madrid)"},{"key":"10.1157\/13116328_bb0030","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1001\/jama.288.16.2023","article-title":"T-polymorphism and risk of coronary heart disease: a meta-analysis","volume":"288","author":"Klerk","year":"2002","journal-title":"JAMA"},{"key":"10.1157\/13116328_bb0035","first-page":"464","article-title":"C677TT mutation in methylentetrahydrofolate reductase, homocysteine and thrombophilia","volume":"202","author":"Grasa","year":"2002","journal-title":"Rev Clin Esp"},{"key":"10.1157\/13116328_bb0040","doi-asserted-by":"crossref","first-page":"630","DOI":"10.33588\/rn.4310.2005542","article-title":"Polimorfismo C677T del gen de la metilentetrahidrofolato reductasa (MTHFR) en la patolog\u00eda isqu\u00e9mica vascular","volume":"43","author":"S\u00e1nchez","year":"2006","journal-title":"Rev Neurol"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775308713976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775308713976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T21:26:46Z","timestamp":1738186006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775308713976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0025775308713976"],"URL":"https:\/\/doi.org\/10.1157\/13116328","relation":{},"ISSN":["0025-7753"],"issn-type":[{"type":"print","value":"0025-7753"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}