{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:03:14Z","timestamp":1784350994856,"version":"3.55.0"},"reference-count":61,"publisher":"American Association for Cancer Research (AACR)","issue":"9","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thyroid cancer is the most common type of endocrine malignancy, with approximately 55,000 new cases diagnosed in the United States in 2012. However, thyroid nodules are much more prevalent, particularly with increased age, and only a small fraction of those are malignant. Therefore, the major clinical challenge is to reliably differentiate those nodules that are malignant and need to be treated surgically from the majority of nodules that are benign and do not require surgery. The traditional diagnostic approach to this clinical situation is ultrasound-guided fine-needle aspiration (FNA) of the thyroid nodule followed by cytologic examination, which together reliably establish the diagnosis in 70% to 80% of cases. However, in the rest of nodules the presence of cancer cannot be ruled out by FNA cytology, hampering appropriate surgical management and frequently resulting in unnecessary surgical interventions. New approaches to diagnosis of cancer in thyroid nodules are based on mutational and other molecular markers, which can be reliably detected in cells aspirated during the FNA procedure. These markers offer significant improvement in the diagnostic accuracy of FNA cytology and are poised to make a profound effect on the management of patients with thyroid nodules. In addition to the molecular markers that have recently become available for clinical use, rapid development of new sequencing techniques is expected to further improve the accuracy of cancer diagnosis in thyroid nodules and allow for a fully individualized approach to the management of patients with thyroid nodules. Clin Cancer Res; 19(9); 2283\u20138. \u00a92013 AACR.<\/jats:p>","DOI":"10.1158\/1078-0432.ccr-12-1253","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T04:15:06Z","timestamp":1361333706000},"page":"2283-2288","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["New Strategies in Diagnosing Cancer in Thyroid Nodules: Impact of Molecular Markers"],"prefix":"10.1158","volume":"19","author":[{"given":"Yuri E.","family":"Nikiforov","sequence":"first","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Pathology and Laboratory Medicine, and 2Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linwah","family":"Yip","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Pathology and Laboratory Medicine, and 2Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina N.","family":"Nikiforova","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Pathology and Laboratory Medicine, and 2Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"2022061100014511000_bib1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0002-9343(92)90163-6","article-title":"Thyroid cancer in thyroid nodules: finding a needle in the haystack","volume":"93","author":"Mazzaferri","year":"1992","journal-title":"Am J Med"},{"key":"2022061100014511000_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4158\/EP.10.1.31","article-title":"Changing trends in thyroid practice: understanding nodular thyroid disease","volume":"10","author":"Gharib","year":"2004","journal-title":"Endocr Pract"},{"key":"2022061100014511000_bib3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJM198508153130707","article-title":"Nodular thyroid disease. Evaluation and management","volume":"313","author":"Rojeski","year":"1985","journal-title":"N Engl J Med"},{"key":"2022061100014511000_bib4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1056\/NEJM199302253280807","article-title":"Management of a solitary thyroid nodule","volume":"328","author":"Mazzaferri","year":"1993","journal-title":"N Engl J Med"},{"key":"2022061100014511000_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.7863\/jum.1998.17.8.487","article-title":"Thyroid palpation versus high-resolution thyroid ultrasonography in the detection of nodules","volume":"17","author":"Wiest","year":"1998","journal-title":"J Ultrasound Med"},{"key":"2022061100014511000_bib6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2362.2009.02162.x","article-title":"Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination","volume":"39","author":"Guth","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"2022061100014511000_bib7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/thy.2012.0156","article-title":"Prevalence of thyroid cancer in multinodular goiter vs. single nodule: a systematic review and meta-analysis","volume":"23","author":"Brito","year":"2013","journal-title":"Thyroid"},{"key":"2022061100014511000_bib8","article-title":"Cancer facts and figures","author":"American Cancer Society","year":"2012"},{"key":"2022061100014511000_bib9","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid"},{"key":"2022061100014511000_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF03346587","article-title":"American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations","volume":"33","author":"Gharib","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"2022061100014511000_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1159\/000334218","article-title":"Variability in the atypia of undetermined significance\/follicular lesion of undetermined significance diagnosis in the Bethesda system for reporting thyroid cytopathology: sources and recommendations","volume":"55","author":"Ohori","year":"2011","journal-title":"Acta Cytol"},{"key":"2022061100014511000_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/dc.20830","article-title":"Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference","volume":"36","author":"Baloch","year":"2008","journal-title":"Diagnostic Cytopathol"},{"key":"2022061100014511000_bib13","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-87666-5","article-title":"The Bethesda system for reporting thyroid cytopathology","author":"Ali","year":"2010"},{"key":"2022061100014511000_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/dc.10043","article-title":"Diagnosis of \u201cfollicular neoplasm\u201d: a gray zone in thyroid fine-needle aspiration cytology","volume":"26","author":"Baloch","year":"2002","journal-title":"Diagnostic Cytopathol"},{"key":"2022061100014511000_bib15","first-page":"569","article-title":"Molecular genetics and diagnosis of thyroid cancer","volume":"7","author":"Nikiforov","year":"2011","journal-title":"Nat Rev"},{"key":"2022061100014511000_bib16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/01.pas.0000176432.73455.1b","article-title":"Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas","volume":"30","author":"Adeniran","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"2022061100014511000_bib17","first-page":"1454","article-title":"High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET\/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma","volume":"63","author":"Kimura","year":"2003","journal-title":"Cancer Res"},{"key":"2022061100014511000_bib18","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1038\/sj.onc.1206706","article-title":"BRAF mutations and RET\/PTC rearrangements are alternative events in the etiopathogenesis of PTC","volume":"22","author":"Soares","year":"2003","journal-title":"Oncogene"},{"key":"2022061100014511000_bib19","doi-asserted-by":"crossref","first-page":"7436","DOI":"10.1038\/sj.onc.1207980","article-title":"Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer","volume":"23","author":"Frattini","year":"2004","journal-title":"Oncogene"},{"key":"2022061100014511000_bib20","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1210\/jc.2002-021907","article-title":"RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma","volume":"88","author":"Nikiforova","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib21","doi-asserted-by":"crossref","first-page":"10199","DOI":"10.1158\/0008-5472.CAN-04-4259","article-title":"Mutation of the PIK3CA gene in anaplastic thyroid cancer","volume":"65","author":"Garcia-Rostan","year":"2005","journal-title":"Cancer Res"},{"key":"2022061100014511000_bib22","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1158\/1078-0432.CCR-06-1125","article-title":"Genetic alterations and their relationship in the phosphatidylinositol 3-kinase\/Akt pathway in thyroid cancer","volume":"13","author":"Hou","year":"2007","journal-title":"Clin Cancer Res"},{"key":"2022061100014511000_bib23","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1158\/0008-5472.CAN-09-0727","article-title":"Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1","volume":"69","author":"Ricarte-Filho","year":"2009","journal-title":"Cancer Res"},{"key":"2022061100014511000_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrc1836","article-title":"Pathogenetic mechanisms in thyroid follicular-cell neoplasia","volume":"6","author":"Kondo","year":"2006","journal-title":"Nat Rev"},{"key":"2022061100014511000_bib25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/er.2006-0017","article-title":"RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors","volume":"27","author":"de Groot","year":"2006","journal-title":"Endocrine Rev"},{"key":"2022061100014511000_bib26","doi-asserted-by":"crossref","first-page":"E863","DOI":"10.1210\/jc.2010-1921","article-title":"High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas","volume":"96","author":"Moura","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib27","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1089\/thy.2007.0008","article-title":"Fine-needle aspiration molecular analysis for the diagnosis of papillary thyroid carcinoma through BRAF V600E mutation and RET\/PTC rearrangement","volume":"17","author":"Pizzolanti","year":"2007","journal-title":"Thyroid"},{"key":"2022061100014511000_bib28","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1158\/1078-0432.CCR-03-0273","article-title":"Mutational analysis of BRAF in fine needle aspiration biopsies of the thyroid: a potential application for the preoperative assessment of thyroid nodules","volume":"10","author":"Cohen","year":"2004","journal-title":"Clin Cancer Res"},{"key":"2022061100014511000_bib29","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1210\/jc.2010-1082","article-title":"Surgical results of thyroid nodules according to a management guideline based on the BRAF(V600E) mutation status","volume":"96","author":"Kim","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib30","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1210\/jc.2009-2795","article-title":"BRAFV600E mutation analysis in fine-needle aspiration cytology specimens for evaluation of thyroid nodule: a large series in a BRAFV600E-prevalent population","volume":"95","author":"Kim","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib31","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1210\/jc.2011-1469","article-title":"Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples","volume":"96","author":"Nikiforov","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib32","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1210\/jc.2009-0247","article-title":"Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules","volume":"94","author":"Nikiforov","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib33","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1210\/jc.2009-2103","article-title":"Impact of proto-oncogene mutation detection in cytological specimens from thyroid nodules improves the diagnostic accuracy of cytology","volume":"95","author":"Cantara","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib34","first-page":"152","article-title":"Follicular carcinoma","author":"Nikiforov","year":"2012","edition":"2nd ed"},{"key":"2022061100014511000_bib35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1309\/ND8D9LAJTRCTG6QD","article-title":"Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations","volume":"120","author":"Zhu","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"2022061100014511000_bib36","first-page":"903","article-title":"Minireview: branded from the start-distinct oncogenic initiating events may determine tumor fate in the thyroid","volume":"16","author":"Fagin","year":"2002","journal-title":"Mol Endocrinol"},{"key":"2022061100014511000_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/mc.2940060208","article-title":"Stepwise transformation of primary thyroid epithelial cells by a mutant Ha-ras oncogene: an in vitro model of tumor progression","volume":"6","author":"Burns","year":"1992","journal-title":"Mol Carcinogenesis"},{"key":"2022061100014511000_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/cncy.20063","article-title":"Contribution of molecular testing to thyroid fine-needle aspiration cytology of \u201cfollicular lesion of undetermined significance\/atypia of undetermined significance","volume":"118","author":"Ohori","year":"2010","journal-title":"Cancer Cytopathol"},{"key":"2022061100014511000_bib39","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1210\/jc.2010-1087","article-title":"Molecular classification of thyroid nodules using high-dimensionality genomic data","volume":"95","author":"Chudova","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib40","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1056\/NEJMoa1203208","article-title":"Preoperative diagnosis of benign thyroid nodules with indeterminate cytology","volume":"367","author":"Alexander","year":"2012","journal-title":"N Engl J Med"},{"key":"2022061100014511000_bib41","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1210\/er.2007-0007","article-title":"BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications","volume":"28","author":"Xing","year":"2007","journal-title":"Endocrine Rev"},{"key":"2022061100014511000_bib42","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1210\/jc.2005-0987","article-title":"BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer","volume":"90","author":"Xing","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib43","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1365-2265.2006.02605.x","article-title":"The BRAF mutation is useful for prediction of clinical recurrence in low-risk patients with conventional papillary thyroid carcinoma","volume":"65","author":"Kim","year":"2006","journal-title":"Clin Endocrinol"},{"key":"2022061100014511000_bib44","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/SLA.0b013e318148563d","article-title":"The prevalence and prognostic value of BRAF mutation in thyroid cancer","volume":"246","author":"Kebebew","year":"2007","journal-title":"Ann Surgery"},{"key":"2022061100014511000_bib45","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1200\/JCO.2008.20.1426","article-title":"BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer","volume":"27","author":"Xing","year":"2009","journal-title":"J Clin Oncol"},{"key":"2022061100014511000_bib46","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1210\/jc.2008-0607","article-title":"BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study","volume":"93","author":"Elisei","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib47","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1210\/jc.2012-1775","article-title":"The BRAFV600E mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study","volume":"97","author":"Elisei","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1245\/s10434-012-2611-0","article-title":"BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer","volume":"20","author":"Howell","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"2022061100014511000_bib49","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.surg.2009.09.011","article-title":"Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation","volume":"146","author":"Yip","year":"2009","journal-title":"Surgery"},{"key":"2022061100014511000_bib50","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.surg.2010.09.005","article-title":"BRAF(V600E) mutation is associated with an increased risk of nodal recurrence requiring reoperative surgery in patients with papillary thyroid cancer","volume":"148","author":"O'Neill","year":"2010","journal-title":"Surgery"},{"key":"2022061100014511000_bib51","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mce.2009.10.012","article-title":"Prognostic utility of BRAF mutation in papillary thyroid cancer","volume":"321","author":"Xing","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"2022061100014511000_bib52","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1210\/jc.2010-0337","article-title":"Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases","volume":"95","author":"Basolo","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib53","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/cncr.22912","article-title":"BRAF V600E mutation and p27 kip1 expression in papillary carcinomas of the thyroid &lt;or = 1 cm and their paired lymph node metastases","volume":"110","author":"Rodolico","year":"2007","journal-title":"Cancer"},{"key":"2022061100014511000_bib54","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1245\/s10434-008-0233-3","article-title":"Analysis of differential BRAF(V600E) mutational status in high aggressive papillary thyroid microcarcinoma","volume":"16","author":"Lee","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"2022061100014511000_bib55","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1210\/jc.2007-1179","article-title":"Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma","volume":"92","author":"Lupi","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061100014511000_bib56","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1677\/ERC-07-0212","article-title":"BRAF(V600E) mutation and the biology of papillary thyroid cancer","volume":"15","author":"Frasca","year":"2008","journal-title":"Endocr Relat Cancer"},{"key":"2022061100014511000_bib57","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1148\/radiol.2533090471","article-title":"Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma","volume":"253","author":"Kwak","year":"2009","journal-title":"Radiology"},{"key":"2022061100014511000_bib58","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1245\/s10434-010-1129-6","article-title":"The BRAF mutation is predictive of aggressive clinicopathological characteristics in papillary thyroid microcarcinoma","volume":"17","author":"Lin","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"2022061100014511000_bib59","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1245\/s10434-011-1781-5","article-title":"Both BRAF V600E mutation and older age (&gt;\/= 65 years) are associated with recurrent papillary thyroid cancer","volume":"18","author":"Howell","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"2022061100014511000_bib60","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1002\/cncr.26425","article-title":"A combined molecular-pathological score improves risk stratification of thyroid papillary microcarcinoma","volume":"118","author":"Niemeier","year":"2012","journal-title":"Cancer"},{"key":"2022061100014511000_bib61","article-title":"Testing for 740 mutations in thyroid samples using targeted next generation sequencing approach","author":"Nikiforova","year":"2012"}],"container-title":["Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/clincancerres\/article-pdf\/19\/9\/2283\/2339514\/2283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/clincancerres\/article-pdf\/19\/9\/2283\/2339514\/2283.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T10:14:36Z","timestamp":1654942476000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/clincancerres\/article\/19\/9\/2283\/78175\/New-Strategies-in-Diagnosing-Cancer-in-Thyroid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,30]]},"references-count":61,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,4,30]]},"published-print":{"date-parts":[[2013,5,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1078-0432.ccr-12-1253","relation":{},"ISSN":["1078-0432","1557-3265"],"issn-type":[{"value":"1078-0432","type":"print"},{"value":"1557-3265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,30]]}}}