{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:10:31Z","timestamp":1654560631994},"reference-count":10,"publisher":"American Association for Cancer Research (AACR)","issue":"10","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: DNA repair has been shown to affect the cellular response to platinum-based therapy in a variety of cancers; however, translating this knowledge to the clinic has proven difficult and yielded mixed results. In this issue of Cancer Discovery, Van Allen and colleagues have analyzed responders and nonresponders to neoadjuvant platinum-based therapy with locally advanced urothelial cancer and identified a series of mutations in the nucleotide excision repair (NER) gene ERCC2 that correlate with the response to platinum-based therapy. This work provides evidence that defects in NER can be exploited to maximize the efficacy of conventional platinum-based chemotherapy. Cancer Discov; 4(10); 1118\u20139. \u00a92014 AACR.<\/jats:p>\n               <jats:p>See related article by Van Allen and colleagues, p. 1140<\/jats:p>","DOI":"10.1158\/2159-8290.cd-14-0893","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T08:00:18Z","timestamp":1412150418000},"page":"1118-1119","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Testing the Metal of ERCC2 in Predicting the Response to Platinum-Based Therapy"],"prefix":"10.1158","volume":"4","author":[{"given":"John J.","family":"Turchi","sequence":"first","affiliation":[{"name":"1Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana."},{"name":"2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek S.","family":"Woods","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela VanderVere","family":"Carozza","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"2022060623332670000_bib1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1200\/JCO.2012.43.0900","article-title":"ERCC1 and RRM1: ready for prime time?","volume":"31","author":"Besse","year":"2013","journal-title":"J Clin Oncol"},{"key":"2022060623332670000_bib2","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1056\/NEJMoa1214271","article-title":"ERCC1 isoform expression and DNA repair in non-small-cell lung 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