{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T15:33:27Z","timestamp":1776008007670,"version":"3.50.1"},"reference-count":10,"publisher":"American Association for Cancer Research (AACR)","issue":"1","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: The cellular phenotype of B-cell lymphomas arising from B cells undergoing germinal center reactions, such as follicular lymphoma and diffuse large B-cell lymphoma, is strongly shaped by mutations in chromatin-modifying genes. The work presented by Jiang and colleagues addresses how somatic mutations in CREBBP disable acetylation and cause unopposed deacetylation by BCL6\/SMRT\/HDAC3 complexes on enhancers of B-cell signaling and immune response genes. This opens a therapeutic avenue toward targeted inhibition of CREBBP-mutant lymphomas by HDAC inhibitors. Cancer Discov; 7(1); 14\u20136. \u00a92017 AACR.<\/jats:p>\n               <jats:p>See related article by Jiang et al., p. 38.<\/jats:p>","DOI":"10.1158\/2159-8290.cd-16-1285","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T05:50:22Z","timestamp":1483681822000},"page":"14-16","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Targeting HDAC3 in <i>CREBBP<\/i>-Mutant Lymphomas Counterstrikes Unopposed Enhancer Deacetylation of B-cell Signaling and Immune Response Genes"],"prefix":"10.1158","volume":"7","author":[{"given":"Uta E.","family":"H\u00f6pken","sequence":"first","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"2022060700353188400_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B-cell lymphoma pathogenesis","volume":"5","author":"Kuppers","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"2022060700353188400_bib2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/leu.2014.209","article-title":"Genomic and epigenomic co-evolution in follicular lymphomas","volume":"29","author":"Loeffler","year":"2015","journal-title":"Leukemia"},{"key":"2022060700353188400_bib3","doi-asserted-by":"crossref","first-page":"e361","DOI":"10.1038\/bcj.2015.89","article-title":"Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas","volume":"5","author":"Lunning","year":"2015","journal-title":"Blood Cancer J"},{"key":"2022060700353188400_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nature09730","article-title":"Inactivating mutations of acetyltransferase genes in B-cell lymphoma","volume":"471","author":"Pasqualucci","year":"2011","journal-title":"Nature"},{"key":"2022060700353188400_bib5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10351","article-title":"Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma","volume":"476","author":"Morin","year":"2011","journal-title":"Nature"},{"key":"2022060700353188400_bib6","doi-asserted-by":"crossref","first-page":"E1116","DOI":"10.1073\/pnas.1501199112","article-title":"Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation","volume":"112","author":"Green","year":"2015","journal-title":"P Natl Acad Sci U S A"},{"key":"2022060700353188400_bib7","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/nm.3940","article-title":"Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat Med"},{"key":"2022060700353188400_bib8","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/nm.3943","article-title":"The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development","volume":"21","author":"Ortega-Molina","year":"2015","journal-title":"Nat Med"},{"key":"2022060700353188400_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1158\/2159-8290.CD-16-0975","article-title":"CREBBP inactivation promotes the development of HDAC3-dependent lymphomas","volume":"7","author":"Jiang","year":"2017","journal-title":"Cancer Discov"},{"key":"2022060700353188400_bib10","doi-asserted-by":"crossref","first-page":"19340","DOI":"10.1038\/srep19340","article-title":"dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes","volume":"6","author":"Nanda","year":"2016","journal-title":"Sci Rep"}],"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/7\/1\/14\/1837098\/14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/7\/1\/14\/1837098\/14.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:35:55Z","timestamp":1654562155000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/7\/1\/14\/5680\/Targeting-HDAC3-in-CREBBP-Mutant-Lymphomas"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,5]]},"published-print":{"date-parts":[[2017,1,1]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-16-1285","relation":{},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]}}}