{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:37:49Z","timestamp":1790739469167,"version":"4.1.0"},"reference-count":10,"publisher":"American Association for Cancer Research (AACR)","issue":"12","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary:<\/jats:title>\n                  <jats:p>Malignant pleural mesothelioma (MPM) is an aggressive lethal malignancy for which very few therapeutic options exist. In this issue of Cancer Discovery, Hmeljak and colleagues report on a comprehensive integrative analysis of histology-independent genomic characteristics of MPM. They confirm previous observations that inactivation of tumor suppressor genes is the predominant oncogenic mechanism. This study provides a scientific rationale for potentially novel therapeutic options, including immune-checkpoint targeting VISTA and small-molecule inhibitors targeting the epigenome, DNA-repair pathways, and aurora kinase.<\/jats:p>\n                  <jats:p>See related article by Hmeljak et al., p. 1548.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-18-1181","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T13:45:18Z","timestamp":1543844718000},"page":"1508-1510","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Molecular Characterization of Malignant Mesothelioma: Time for New Targets?"],"prefix":"10.1158","volume":"8","author":[{"given":"Charu","family":"Aggarwal","sequence":"first","affiliation":[{"name":"1Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 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