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These cancer types are also those that, when they occur sporadically, are more likely to carry somatic biallelic BAP1 mutations. Mechanistic studies revealed that the tumor suppressor function of BAP1 is linked to its dual activity in the nucleus, where it is implicated in a variety of processes including DNA repair and transcription, and in the cytoplasm, where it regulates cell death and mitochondrial metabolism. BAP1 activity in tumor suppression is cell type\u2013 and context-dependent. BAP1 has emerged as a critical tumor suppressor across multiple cancer types, predisposing to tumor development when mutated in the germline as well as somatically. Moreover, BAP1 has emerged as a key regulator of gene\u2013environment interaction.<\/jats:p>\n                  <jats:p>This article is highlighted in the In This Issue feature, p. 1079<\/jats:p>","DOI":"10.1158\/2159-8290.cd-19-1220","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T14:45:11Z","timestamp":1595256311000},"page":"1103-1120","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":272,"title":["Biological Mechanisms and Clinical Significance of\n                    <i>BAP1<\/i>\n                    Mutations in Human Cancer"],"prefix":"10.1158","volume":"10","author":[{"given":"Michele","family":"Carbone","sequence":"first","affiliation":[{"name":"1University of Hawai'i Cancer Center, Honolulu, Hawai'i."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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