{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:26:37Z","timestamp":1767857197114,"version":"3.49.0"},"reference-count":9,"publisher":"American Association for Cancer Research (AACR)","issue":"5","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary:<\/jats:title>\n                  <jats:p>Primary sclerosing cholangitis and colitis are known predisposing factors for bile duct cancer, but their exact pro-oncogenic mechanisms are unclear. In this issue of Cancer Discovery, Zhang and colleagues identify intestinal barrier impairment as a key mechanism, resulting in gut microbes spilling into the portal vein, in turn recruiting immunosuppressive myeloid-derived suppressor cells and promoting cholangiocarcinoma.<\/jats:p>\n                  <jats:p>See related article by Zhang et al. p. 1248.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-21-0187","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T08:40:25Z","timestamp":1620117625000},"page":"1014-1015","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cholangiocarcinoma Risk Factors Open the Floodgates for Gut Microbes and Immunosuppressive Myeloid Cells"],"prefix":"10.1158","volume":"11","author":[{"given":"Sharmeen","family":"Chagani","sequence":"first","affiliation":[{"name":"Department of Translational Molecular Pathology, The University of 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