{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:16:46Z","timestamp":1792174606876,"version":"4.4.0"},"reference-count":94,"publisher":"American Association for Cancer Research (AACR)","issue":"7","funder":[{"name":"National Cancer Institute","award":["1K99CA252602"],"award-info":[{"award-number":["1K99CA252602"]}]},{"name":"National Cancer Institute","award":["R01CA178394"],"award-info":[{"award-number":["R01CA178394"]}]},{"name":"National Cancer Institute","award":["R01CA223243"],"award-info":[{"award-number":["R01CA223243"]}]},{"name":"National Cancer Institute","award":["P30CA013330"],"award-info":[{"award-number":["P30CA013330"]}]},{"name":"National Cancer Institute","award":["R01CA216421"],"award-info":[{"award-number":["R01CA216421"]}]},{"name":"National Cancer Institute","award":["R01CA173636"],"award-info":[{"award-number":["R01CA173636"]}]},{"name":"National Cancer Institute","award":["R01CA228135"],"award-info":[{"award-number":["R01CA228135"]}]},{"name":"National Cancer Institute","award":["P01CA229086"],"award-info":[{"award-number":["P01CA229086"]}]},{"name":"National Cancer Institute","award":["R01CA242020"],"award-info":[{"award-number":["R01CA242020"]}]},{"name":"National Cancer Institute","award":["P30CA016087"],"award-info":[{"award-number":["P30CA016087"]}]},{"name":"Leukemia and Lymphoma Society","award":["3409-21"],"award-info":[{"award-number":["3409-21"]}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>BH3 mimetics are used as an efficient strategy to induce cell death in several blood malignancies, including acute myeloid leukemia (AML). Venetoclax, a potent BCL-2 antagonist, is used clinically in combination with hypomethylating agents for the treatment of AML. Moreover, MCL1 or dual BCL-2\/BCL-xL antagonists are under investigation. Yet, resistance to single or combinatorial BH3-mimetic therapies eventually ensues. Integration of multiple genome-wide CRISPR\/Cas9 screens revealed that loss of mitophagy modulators sensitizes AML cells to various BH3 mimetics targeting different BCL-2 family members. One such regulator is MFN2, whose protein levels positively correlate with drug resistance in patients with AML. MFN2 overexpression is sufficient to drive resistance to BH3 mimetics in AML. Insensitivity to BH3 mimetics is accompanied by enhanced mitochondria\u2013endoplasmic reticulum interactions and augmented mitophagy flux, which acts as a prosurvival mechanism to eliminate mitochondrial damage. Genetic or pharmacologic MFN2 targeting synergizes with BH3 mimetics by impairing mitochondrial clearance and enhancing apoptosis in AML.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>AML remains one of the most difficult-to-treat blood cancers. BH3 mimetics represent a promising therapeutic approach to eliminate AML blasts by activating the apoptotic pathway. Enhanced mitochondrial clearance drives resistance to BH3 mimetics and predicts poor prognosis. Reverting excessive mitophagy can halt BH3-mimetic resistance in AML.<\/jats:p>\n                    <jats:p>This article is highlighted in the In This Issue feature, p. 1501<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-22-0601","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:10:00Z","timestamp":1682295000000},"page":"1656-1677","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia"],"prefix":"10.1158","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-338X","authenticated-orcid":false,"given":"Christina","family":"Glytsou","sequence":"first","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."},{"name":"3Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey."},{"name":"4Department of Pediatrics, Robert Wood Johnson Medical School, and Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, New Jersey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-971X","authenticated-orcid":false,"given":"Xufeng","family":"Chen","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2781-9553","authenticated-orcid":false,"given":"Emmanouil","family":"Zacharioudakis","sequence":"additional","affiliation":[{"name":"5Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York."},{"name":"6Department of Medicine, Albert Einstein College of Medicine, Bronx, New York."},{"name":"7Montefiore Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6332-8789","authenticated-orcid":false,"given":"Wafa","family":"Al-Santli","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1822-1306","authenticated-orcid":false,"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"8Applied Bioinformatics Laboratories, NYU School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-8425","authenticated-orcid":false,"given":"Bettina","family":"Nadorp","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."},{"name":"8Applied Bioinformatics Laboratories, NYU School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-3751","authenticated-orcid":false,"given":"Soobeom","family":"Lee","sequence":"additional","affiliation":[{"name":"9Department of Biology, New York University, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6588-6760","authenticated-orcid":false,"given":"Audrey","family":"Lasry","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9252-2871","authenticated-orcid":false,"given":"Zhengxi","family":"Sun","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1404-279X","authenticated-orcid":false,"given":"Dimitrios","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4930-1739","authenticated-orcid":false,"given":"Michael","family":"Cammer","sequence":"additional","affiliation":[{"name":"10Microscopy Core, Division of Advanced Research Technologies, New York University Grossman School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8708-6354","authenticated-orcid":false,"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-4261","authenticated-orcid":false,"given":"Tomasz","family":"Zal","sequence":"additional","affiliation":[{"name":"11Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1015-3954","authenticated-orcid":false,"given":"Malgorzata Anna","family":"Zal","sequence":"additional","affiliation":[{"name":"11Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-0889","authenticated-orcid":false,"given":"Bing Z.","family":"Carter","sequence":"additional","affiliation":[{"name":"11Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-7370","authenticated-orcid":false,"given":"Jo","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"11Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-8733","authenticated-orcid":false,"given":"Raoul","family":"Tibes","sequence":"additional","affiliation":[{"name":"12AstraZeneca, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-8477","authenticated-orcid":false,"given":"Aristotelis","family":"Tsirigos","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"8Applied Bioinformatics Laboratories, NYU School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-1958","authenticated-orcid":false,"given":"Michael","family":"Andreeff","sequence":"additional","affiliation":[{"name":"11Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-8331","authenticated-orcid":false,"given":"Evripidis","family":"Gavathiotis","sequence":"additional","affiliation":[{"name":"5Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York."},{"name":"6Department of Medicine, Albert Einstein College of Medicine, Bronx, New York."},{"name":"7Montefiore Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-1035","authenticated-orcid":false,"given":"Iannis","family":"Aifantis","sequence":"additional","affiliation":[{"name":"1Department of Pathology, NYU Grossman School of Medicine, New York, New York."},{"name":"2Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU Grossman School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"2025121106571484400_bib1","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2025121106571484400_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11912-019-0764-8","article-title":"New treatment options for acute myeloid leukemia in 2019","volume":"21","author":"Cerrano","year":"2019","journal-title":"Curr Oncol Rep"},{"key":"2025121106571484400_bib3","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1158\/2159-8290.CD-16-0313","article-title":"Efficacy and biological correlates of response in a phase II study of venetoclax monotherapy in patients with acute myelogenous leukemia","volume":"6","author":"Konopleva","year":"2016","journal-title":"Cancer Discov"},{"key":"2025121106571484400_bib4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1158\/2159-8290.CD-19-1011","article-title":"Advances in the treatment of acute myeloid leukemia: new drugs and new challenges","volume":"10","author":"Short","year":"2020","journal-title":"Cancer Discov"},{"key":"2025121106571484400_bib5","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/S2152-2650(20)30450-X","article-title":"Venetoclax in AML: where we are and where we are headed","volume":"20","author":"Pollyea","year":"2020","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"2025121106571484400_bib6","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1182\/bloodadvances.2019000937","article-title":"Venetoclax for AML: changing the treatment paradigm","volume":"3","author":"Pollyea","year":"2019","journal-title":"Blood Adv"},{"key":"2025121106571484400_bib7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.ccell.2017.11.003","article-title":"Synthetic lethality of combined Bcl-2 inhibition and p53 activation in AML: mechanisms and superior antileukemic efficacy","volume":"32","author":"Pan","year":"2017","journal-title":"Cancer Cell"},{"key":"2025121106571484400_bib8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1158\/2159-8290.CD-19-0125","article-title":"The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells","volume":"9","author":"Nechiporuk","year":"2019","journal-title":"Cancer Discov"},{"key":"2025121106571484400_bib9","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s43018-020-0103-x","article-title":"Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia","volume":"1","author":"Zhang","year":"2020","journal-title":"Nat Cancer"},{"key":"2025121106571484400_bib10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1182\/blood.2019003988","article-title":"Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML","volume":"135","author":"DiNardo","year":"2020","journal-title":"Blood"},{"key":"2025121106571484400_bib11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1182\/blood.2022016090","article-title":"Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia","volume":"141","author":"Moujalled","year":"2023","journal-title":"Blood"},{"key":"2025121106571484400_bib12","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/2159-8290.CD-19-0117","article-title":"Targeting mitochondrial structure sensitizes acute myeloid leukemia to venetoclax treatment","volume":"9","author":"Chen","year":"2019","journal-title":"Cancer Discov"},{"key":"2025121106571484400_bib13","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s43018-020-00126-z","article-title":"Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells","volume":"1","author":"Stevens","year":"2020","journal-title":"Nat Cancer"},{"key":"2025121106571484400_bib14","doi-asserted-by":"crossref","first-page":"16837","DOI":"10.1038\/s41598-018-35198-6","article-title":"Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine","volume":"8","author":"Tabe","year":"2018","journal-title":"Sci Rep"},{"key":"2025121106571484400_bib15","doi-asserted-by":"crossref","first-page":"eaax2863","DOI":"10.1126\/scitranslmed.aax2863","article-title":"Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response","volume":"11","author":"Sharon","year":"2019","journal-title":"Sci Transl Med"},{"key":"2025121106571484400_bib16","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/s43018-021-00264-y","article-title":"Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia","volume":"2","author":"Bosc","year":"2021","journal-title":"Nature Cancer"},{"key":"2025121106571484400_bib17","doi-asserted-by":"crossref","first-page":"ra17","DOI":"10.1126\/scisignal.aac4380","article-title":"ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies","volume":"9","author":"Ishizawa","year":"2016","journal-title":"Sci Signal"},{"key":"2025121106571484400_bib18","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ccell.2019.03.014","article-title":"Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality","volume":"35","author":"Ishizawa","year":"2019","journal-title":"Cancer Cell"},{"key":"2025121106571484400_bib19","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.ccell.2020.10.010","article-title":"Reduced mitochondrial apoptotic priming drives resistance to BH3 mimetics in acute myeloid leukemia","volume":"38","author":"Bhatt","year":"2020","journal-title":"Cancer Cell"},{"key":"2025121106571484400_bib20","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1158\/2159-8290.CD-18-0387","article-title":"AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies","volume":"8","author":"Caenepeel","year":"2018","journal-title":"Cancer Discov"},{"key":"2025121106571484400_bib21","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1038\/s41467-018-07551-w","article-title":"Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia","volume":"9","author":"Tron","year":"2018","journal-title":"Nat Commun"},{"key":"2025121106571484400_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3324\/haematol.2020.260331","article-title":"Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and resensitizes acute myeloid leukemia to BCL-2 inhibition","volume":"107","author":"Carter","year":"2022","journal-title":"Haematologica"},{"key":"2025121106571484400_bib23","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1158\/2159-8290.CD-18-0140","article-title":"A novel MCL1 inhibitor combined with venetoclax rescues venetoclax-resistant acute myelogenous leukemia","volume":"8","author":"Ramsey","year":"2018","journal-title":"Cancer Discov"},{"key":"2025121106571484400_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature19830","article-title":"The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models","volume":"538","author":"Kotschy","year":"2016","journal-title":"Nature"},{"key":"2025121106571484400_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41392-020-0112-3","article-title":"Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia","volume":"5","author":"Luedtke","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"2025121106571484400_bib26","doi-asserted-by":"crossref","first-page":"107206","DOI":"10.18632\/oncotarget.22284","article-title":"Combined venetoclax and alvocidib in acute myeloid leukemia","volume":"8","author":"Bogenberger","year":"2017","journal-title":"Oncotarget"},{"key":"2025121106571484400_bib27","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3389\/fonc.2019.01205","article-title":"Transcriptional silencing of MCL-1 through cyclin-dependent kinase inhibition in acute myeloid leukemia","volume":"9","author":"Tibes","year":"2019","journal-title":"Front Oncol"},{"key":"2025121106571484400_bib28","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat Biotechnol"},{"key":"2025121106571484400_bib29","doi-asserted-by":"crossref","first-page":"e77682","DOI":"10.1371\/journal.pone.0077682","article-title":"OTUD5 regulates p53 stability by deubiquitinating p53","volume":"8","author":"Luo","year":"2013","journal-title":"PLoS One"},{"key":"2025121106571484400_bib30","doi-asserted-by":"crossref","first-page":"e58435","DOI":"10.1371\/journal.pone.0058435","article-title":"Tom70 is essential for PINK1 import into mitochondria","volume":"8","author":"Kato","year":"2013","journal-title":"PLoS One"},{"key":"2025121106571484400_bib31","doi-asserted-by":"crossref","first-page":"31635","DOI":"10.1074\/jbc.M109.041756","article-title":"Roles of Tom70 in import of presequence-containing mitochondrial proteins","volume":"284","author":"Yamamoto","year":"2009","journal-title":"J Biol Chem"},{"key":"2025121106571484400_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molcel.2013.04.023","article-title":"MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2","volume":"51","author":"Sugiura","year":"2013","journal-title":"Mol Cell"},{"key":"2025121106571484400_bib33","doi-asserted-by":"crossref","first-page":"10300","DOI":"10.1074\/jbc.RA118.006302","article-title":"Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL","volume":"294","author":"Koyano","year":"2019","journal-title":"J Biol Chem"},{"key":"2025121106571484400_bib34","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 tethers endoplasmic reticulum to mitochondria","volume":"456","author":"de Brito","year":"2008","journal-title":"Nature"},{"key":"2025121106571484400_bib35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.1231031","article-title":"PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria","volume":"340","author":"Chen","year":"2013","journal-title":"Science"},{"key":"2025121106571484400_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12043","article-title":"Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization","volume":"496","author":"Sarraf","year":"2013","journal-title":"Nature"},{"key":"2025121106571484400_bib37","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3390\/ijms21051772","article-title":"PINK1\/Parkin mediated mitophagy, Ca(2+) signalling, and ER-mitochondria contacts in Parkinson's disease","volume":"21","author":"Barazzuol","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025121106571484400_bib38","doi-asserted-by":"crossref","first-page":"16912","DOI":"10.18632\/oncotarget.4857","article-title":"Cyclin E\/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics","volume":"6","author":"Choudhary","year":"2015","journal-title":"Oncotarget"},{"key":"2025121106571484400_bib39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/1878-0261.12148","article-title":"Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor","volume":"12","author":"Whittaker","year":"2018","journal-title":"Mol Oncol"},{"key":"2025121106571484400_bib40","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1182\/blood-2008-12-196055","article-title":"FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation","volume":"114","author":"Yoshimoto","year":"2009","journal-title":"Blood"},{"key":"2025121106571484400_bib41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood-2020-141399","article-title":"Targeting Mcl-1 enhances the activity of tyrosine kinase inhibitor gilteritinib in FLT3 mutated AML","volume":"136:","author":"Carter","year":"2020","journal-title":"Blood"},{"key":"2025121106571484400_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41408-021-00410-w","article-title":"Triplet therapy with venetoclax, FLT3 inhibitor and decitabine for FLT3-mutated acute myeloid leukemia","volume":"11","author":"Maiti","year":"2021","journal-title":"Blood Cancer J"},{"key":"2025121106571484400_bib43","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1158\/2159-8290.CD-18-1391","article-title":"A gain-of-function p53-mutant oncogene promotes cell fate plasticity and myeloid leukemia through the pluripotency factor FOXH1","volume":"9","author":"Loizou","year":"2019","journal-title":"Cancer Discov"},{"key":"2025121106571484400_bib44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2019.12.023","article-title":"Quantitative proteomics of the cancer cell line encyclopedia","volume":"180","author":"Nusinow","year":"2020","journal-title":"Cell"},{"key":"2025121106571484400_bib45","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","article-title":"Functional genomic landscape of acute myeloid leukaemia","volume":"562","author":"Tyner","year":"2018","journal-title":"Nature"},{"key":"2025121106571484400_bib46","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/jcs.114.5.867","article-title":"Control of mitochondrial morphology by a human mitofusin","volume":"114","author":"Santel","year":"2001","journal-title":"J Cell Sci"},{"key":"2025121106571484400_bib47","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature11910","article-title":"Autophagosomes form at ER-mitochondria contact sites","volume":"495","author":"Hamasaki","year":"2013","journal-title":"Nature"},{"key":"2025121106571484400_bib48","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cell.2010.04.009","article-title":"Mitochondria supply membranes for autophagosome biogenesis during starvation","volume":"141","author":"Hailey","year":"2010","journal-title":"Cell"},{"key":"2025121106571484400_bib49","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/nprot.2017.060","article-title":"A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima","volume":"12","author":"Sun","year":"2017","journal-title":"Nat Protoc"},{"key":"2025121106571484400_bib50","first-page":"58099","article-title":"Sensitive measurement of mitophagy by flow cytometry using the pH-dependent fluorescent reporter mt-Keima","volume":"138","author":"Um","year":"2018","journal-title":"J Vis Exp"},{"key":"2025121106571484400_bib51","doi-asserted-by":"crossref","first-page":"e110600","DOI":"10.1371\/journal.pone.0110600","article-title":"A super-ecliptic, pHluorin-mKate2, tandem fluorescent protein-tagged human LC3 for the monitoring of mammalian autophagy","volume":"9","author":"Tanida","year":"2014","journal-title":"PLoS One"},{"key":"2025121106571484400_bib52","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1182\/blood-2014-08-594408","article-title":"AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress","volume":"125","author":"Sriskanthadevan","year":"2015","journal-title":"Blood"},{"key":"2025121106571484400_bib53","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/j.bmcl.2018.05.013","article-title":"Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy","volume":"28","author":"Kluge","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"2025121106571484400_bib54","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature13418","article-title":"The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy","volume":"510","author":"Bingol","year":"2014","journal-title":"Nature"},{"key":"2025121106571484400_bib55","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.molcel.2019.11.013","article-title":"Global landscape and dynamics of parkin and USP30-dependent ubiquitylomes in iNeurons during mitophagic signaling","volume":"77","author":"Ordureau","year":"2020","journal-title":"Mol Cell"},{"key":"2025121106571484400_bib56","first-page":"27","article-title":"An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia","volume":"4","author":"Lasry","year":"2023","journal-title":"Nat Cancer"},{"key":"2025121106571484400_bib57","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/EBC20170021","article-title":"The mammalian ULK1 complex and autophagy initiation","volume":"61","author":"Zachari","year":"2017","journal-title":"Essays Biochem"},{"key":"2025121106571484400_bib58","doi-asserted-by":"crossref","first-page":"28726","DOI":"10.1074\/jbc.A114.627778","article-title":"Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy","volume":"290","author":"Petherick","year":"2015","journal-title":"J Biol Chem"},{"key":"2025121106571484400_bib59","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1158\/1078-0432.CCR-20-0863","article-title":"AZD4320, a dual inhibitor of Bcl-2 and Bcl-x(L), induces tumor regression in hematologic cancer models without dose-limiting thrombocytopenia","volume":"26","author":"Balachander","year":"2020","journal-title":"Clin Cancer Res"},{"key":"2025121106571484400_bib60","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1080\/15548627.2016.1277309","article-title":"PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation","volume":"13","author":"Gelmetti","year":"2017","journal-title":"Autophagy"},{"key":"2025121106571484400_bib61","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fcell.2018.00137","article-title":"Beclin 1 phosphorylation: at the center of autophagy regulation","volume":"6","author":"Menon","year":"2018","journal-title":"Front Cell Dev Biol"},{"key":"2025121106571484400_bib62","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/cr.2010.82","article-title":"Overview of macroautophagy regulation in mammalian cells","volume":"20","author":"Mehrpour","year":"2010","journal-title":"Cell Res"},{"key":"2025121106571484400_bib63","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1242\/jcs.115.8.1663","article-title":"Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo","volume":"115","author":"Rojo","year":"2002","journal-title":"J Cell Sci"},{"key":"2025121106571484400_bib64","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1083\/jcb.200611080","article-title":"Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations","volume":"176","author":"Detmer","year":"2007","journal-title":"J Cell Biol"},{"key":"2025121106571484400_bib65","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1158\/2159-8290.CD-20-1851","article-title":"An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML","volume":"12","author":"Lin","year":"2022","journal-title":"Cancer Discov"},{"key":"2025121106571484400_bib66","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1038\/s41467-022-31324-1","article-title":"Modulating mitofusins to control mitochondrial function and signaling","volume":"13","author":"Zacharioudakis","year":"2022","journal-title":"Nat Commun"},{"key":"2025121106571484400_bib67","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.canlet.2011.12.021","article-title":"BH3 profiling\u2013measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions","volume":"332","author":"Del Gaizo Moore","year":"2013","journal-title":"Cancer Lett"},{"key":"2025121106571484400_bib68","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025121106571484400_bib69","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.tcb.2018.02.009","article-title":"Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions","volume":"28","author":"Csordas","year":"2018","journal-title":"Trends Cell Biol"},{"key":"2025121106571484400_bib70","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1038\/s41467-020-17882-2","article-title":"Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites","volume":"11","author":"Bosc","year":"2020","journal-title":"Nat Commun"},{"key":"2025121106571484400_bib71","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/cells10030657","article-title":"The MAMs structure and its role in cell death","volume":"10","author":"Wang","year":"2021","journal-title":"Cells"},{"key":"2025121106571484400_bib72","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41556-018-0092-5","article-title":"A brief history of autophagy from cell biology to physiology and disease","volume":"20","author":"Mizushima","year":"2018","journal-title":"Nat Cell Biol"},{"key":"2025121106571484400_bib73","doi-asserted-by":"crossref","first-page":"914","DOI":"10.4161\/auto.7.8.15785","article-title":"BH3 mimetics reveal the network properties of autophagy-regulatory signaling cascades","volume":"7","author":"Malik","year":"2011","journal-title":"Autophagy"},{"key":"2025121106571484400_bib74","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-consumption: the interplay of autophagy and apoptosis","volume":"15","author":"Marino","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025121106571484400_bib75","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/15548627.2016.1245263","article-title":"Targeting autophagy to overcome chemoresistance in acute myleogenous leukemia","volume":"13","author":"Piya","year":"2017","journal-title":"Autophagy"},{"key":"2025121106571484400_bib76","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.stem.2018.05.021","article-title":"AMPK\/FIS1-mediated mitophagy is required for self-renewal of human AML stem cells","volume":"23","author":"Pei","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2025121106571484400_bib77","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1080\/15548627.2020.1749490","article-title":"The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses","volume":"17","author":"Hu","year":"2021","journal-title":"Autophagy"},{"key":"2025121106571484400_bib78","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1038\/emboj.2013.168","article-title":"Mfn2 modulates the UPR and mitochondrial function via repression of PERK","volume":"32","author":"Munoz","year":"2013","journal-title":"EMBO J"},{"key":"2025121106571484400_bib79","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.15252\/embj.201593084","article-title":"Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway","volume":"35","author":"Sebastian","year":"2016","journal-title":"EMBO J"},{"key":"2025121106571484400_bib80","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41418-019-0474-7","article-title":"Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients","volume":"27","author":"Mulcahy Levy","year":"2020","journal-title":"Cell Death Differ"},{"key":"2025121106571484400_bib81","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1212\/WNL.0b013e31821a441e","article-title":"MFN2 mutations cause severe phenotypes in most patients with CMT2A","volume":"76","author":"Feely","year":"2011","journal-title":"Neurology"},{"key":"2025121106571484400_bib82","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1101\/gad.17269211","article-title":"An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance","volume":"25","author":"Zuber","year":"2011","journal-title":"Genes Dev"},{"key":"2025121106571484400_bib83","doi-asserted-by":"crossref","first-page":"W488","DOI":"10.1093\/nar\/gkaa216","article-title":"SynergyFinder 2.0: visual analytics of multi-drug combination synergies","volume":"48","author":"Ianevski","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2025121106571484400_bib84","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s42256-019-0122-4","article-title":"Prediction of drug combination effects with a minimal set of experiments","volume":"1","author":"Ianevski","year":"2019","journal-title":"Nat Mach Intell"},{"key":"2025121106571484400_bib85","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat Biotechnol"},{"key":"2025121106571484400_bib86","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cell.2015.01.042","article-title":"Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy","volume":"160","author":"Montero","year":"2015","journal-title":"Cell"},{"key":"2025121106571484400_bib87","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ymeth.2013.04.006","article-title":"BH3 profiling in whole cells by fluorimeter or FACS","volume":"61","author":"Ryan","year":"2013","journal-title":"Methods"},{"key":"2025121106571484400_bib88","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2018","journal-title":"Nat Biotechnol"},{"key":"2025121106571484400_bib89","doi-asserted-by":"crossref","first-page":"e43803","DOI":"10.7554\/eLife.43803","article-title":"Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq","volume":"8","author":"Kotliar","year":"2019","journal-title":"Elife"},{"key":"2025121106571484400_bib90","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat Immunol"},{"key":"2025121106571484400_bib91","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"2025121106571484400_bib92","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Cancer Genome Atlas Research Network","year":"2013","journal-title":"N Engl J Med"},{"key":"2025121106571484400_bib93","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1158\/0008-5472.CAN-15-1015","article-title":"Genomic profiling of pediatric acute myeloid leukemia reveals a changing mutational landscape from disease diagnosis to relapse","volume":"76","author":"Farrar","year":"2016","journal-title":"Cancer Res"},{"key":"2025121106571484400_bib94","doi-asserted-by":"crossref","first-page":"11249","DOI":"10.1073\/pnas.1606786113","article-title":"Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether","volume":"113","author":"Naon","year":"2016","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/doi\/10.1158\/2159-8290.CD-22-0601\/3287449\/cd-22-0601.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/doi\/10.1158\/2159-8290.CD-22-0601\/3339976\/cd-22-0601.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/13\/7\/1656\/3345703\/1656.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/13\/7\/1656\/3345703\/1656.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:57:39Z","timestamp":1765454259000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/13\/7\/1656\/727604\/Mitophagy-Promotes-Resistance-to-BH3-Mimetics-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,24]]},"references-count":94,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4,24]]},"published-print":{"date-parts":[[2023,7,7]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-22-0601","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1158\/2159-8290.27025355","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515246","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641402.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515261.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515258","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641399","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641405","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641396.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30858963","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025358.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30858951","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515243","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515255","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025361.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515243.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025364.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641411","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515249.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641408","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515252.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515255.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30858954","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515246.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30858966","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515258.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025349","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515252","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641402","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641411.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30858957","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025352.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025352","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025364","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641399.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025355.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025349.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025346","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025358","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515261","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641396","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025346.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641414.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515249","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641414","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641405.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641408.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30858948","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025361","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30858960","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1158\/2159-8290.23515258.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515255.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641402","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641414","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515252.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641396.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641399.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515243","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6695698.v3","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515255","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641411","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515261.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6695698.v2","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515258","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641399","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515246","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6695698","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515246.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515261","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641405.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641408","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641402.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515249.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515243.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641396","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641414.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641408.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641405","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641411.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515249","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6695698.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23515252","asserted-by":"object"}]},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,24]]}}}