{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T15:52:03Z","timestamp":1774194723507,"version":"3.50.1"},"reference-count":72,"publisher":"American Association for Cancer Research (AACR)","issue":"5","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"crossref","award":["MOH-000715-00"],"award-info":[{"award-number":["MOH-000715-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"crossref","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001459","name":"Singapore Ministry of Education","doi-asserted-by":"crossref","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"crossref","award":["MOH-001104"],"award-info":[{"award-number":["MOH-001104"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"crossref","award":["OF-LCG18May-0028"],"award-info":[{"award-number":["OF-LCG18May-0028"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIHR Cambridge Biomedical Research Centre","award":["BRC-1215-20014"],"award-info":[{"award-number":["BRC-1215-20014"]}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"crossref","award":["RCCFEL&#x2216"],"award-info":[{"award-number":["RCCFEL&#x2216"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"crossref","award":["100072"],"award-info":[{"award-number":["100072"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["203151\/Z\/16\/Z"],"award-info":[{"award-number":["203151\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014679","name":"CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester","doi-asserted-by":"crossref","award":["A25117"],"award-info":[{"award-number":["A25117"]}],"id":[{"id":"10.13039\/501100014679","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007076","name":"Italian Foundation for Cancer Research","doi-asserted-by":"crossref","award":["22145"],"award-info":[{"award-number":["22145"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007076","name":"Italian Foundation for Cancer Research","doi-asserted-by":"crossref","award":["22759"],"award-info":[{"award-number":["22759"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer influence clinical outcomes. Using quantitative multispectral imaging of the prognostically relevant oncogenes MYC, BCL2, and BCL6 in diffuse large B-cell lymphoma (DLBCL), we show that the percentage of cells with a unique combination MYC+BCL2+BCL6\u2212 (M+2+6\u2212) consistently predicts survival across four independent cohorts (n = 449), an effect not observed with other combinations including M+2+6+. We show that the M+2+6\u2212 percentage can be mathematically derived from quantitative measurements of the individual oncogenes and correlates with survival in IHC (n = 316) and gene expression (n = 2,521) datasets. Comparative bulk\/single-cell transcriptomic analyses of DLBCL samples and MYC\/BCL2\/BCL6-transformed primary B cells identify molecular features, including cyclin D2 and PI3K\/AKT as candidate regulators of M+2+6\u2212 unfavorable biology. Similar analyses evaluating oncogenic combinations at single-cell resolution in other cancers may facilitate an understanding of cancer evolution and therapy resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>Using single-cell\u2013resolved multiplexed imaging, we show that selected subpopulations of cells expressing specific combinations of oncogenes influence clinical outcomes in lymphoma. We describe a probabilistic metric for the estimation of cellular oncogenic coexpression from IHC or bulk transcriptomes, with possible implications for prognostication and therapeutic target discovery in cancer.<\/jats:p>\n                    <jats:p>This article is highlighted in the In This Issue feature, p. 1027<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-22-0998","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T13:49:55Z","timestamp":1681825795000},"page":"1144-1163","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma"],"prefix":"10.1158","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-6080","authenticated-orcid":false,"given":"Michal Marek","family":"Hoppe","sequence":"first","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-8674","authenticated-orcid":false,"given":"Patrick","family":"Jaynes","sequence":"additional","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-6527","authenticated-orcid":false,"given":"Fan","family":"Shuangyi","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-8547","authenticated-orcid":false,"given":"Yanfen","family":"Peng","sequence":"additional","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-0352","authenticated-orcid":false,"given":"Shruti","family":"Sridhar","sequence":"additional","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-5653","authenticated-orcid":false,"given":"Phuong Mai","family":"Hoang","sequence":"additional","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4172-5238","authenticated-orcid":false,"given":"Clementine Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"3Department of Haematology-Oncology, National University Health System, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8881-3537","authenticated-orcid":false,"given":"Sanjay","family":"De Mel","sequence":"additional","affiliation":[{"name":"3Department of Haematology-Oncology, National University Health System, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8854-9414","authenticated-orcid":false,"given":"Limei","family":"Poon","sequence":"additional","affiliation":[{"name":"3Department of Haematology-Oncology, National University Health System, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-5601","authenticated-orcid":false,"given":"Esther Hian Li","family":"Chan","sequence":"additional","affiliation":[{"name":"3Department of Haematology-Oncology, National University Health System, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9012-598X","authenticated-orcid":false,"given":"Joanne","family":"Lee","sequence":"additional","affiliation":[{"name":"3Department of Haematology-Oncology, National University Health System, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-4288","authenticated-orcid":false,"given":"Choon Kiat","family":"Ong","sequence":"additional","affiliation":[{"name":"5Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-703X","authenticated-orcid":false,"given":"Tiffany","family":"Tang","sequence":"additional","affiliation":[{"name":"6Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5505","authenticated-orcid":false,"given":"Soon Thye","family":"Lim","sequence":"additional","affiliation":[{"name":"6Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-2226","authenticated-orcid":false,"given":"Chandramouli","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"7Department of Haematology, Singapore General Hospital, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-5024","authenticated-orcid":false,"given":"Nicholas F.","family":"Grigoropoulos","sequence":"additional","affiliation":[{"name":"7Department of Haematology, Singapore General Hospital, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-2823","authenticated-orcid":false,"given":"Soo-Yong","family":"Tan","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1854-1481","authenticated-orcid":false,"given":"Susan Swee-Shan","family":"Hue","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4544-6623","authenticated-orcid":false,"given":"Sheng-Tsung","family":"Chang","sequence":"additional","affiliation":[{"name":"8Department of Pathology, Chi-Mei Medical Center, Tainan City, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-525X","authenticated-orcid":false,"given":"Shih-Sung","family":"Chuang","sequence":"additional","affiliation":[{"name":"8Department of Pathology, Chi-Mei Medical Center, Tainan City, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-0523","authenticated-orcid":false,"given":"Shaoying","family":"Li","sequence":"additional","affiliation":[{"name":"9Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-3584","authenticated-orcid":false,"given":"Joseph D.","family":"Khoury","sequence":"additional","affiliation":[{"name":"10Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-3088","authenticated-orcid":false,"given":"Hyungwon","family":"Choi","sequence":"additional","affiliation":[{"name":"11Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9807-1274","authenticated-orcid":false,"suffix":"III","given":"Carl","family":"Harris","sequence":"additional","affiliation":[{"name":"12F. Hoffmann-La Roche Ltd, Basel, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6311-2833","authenticated-orcid":false,"given":"Alessia","family":"Bottos","sequence":"additional","affiliation":[{"name":"12F. Hoffmann-La Roche Ltd, Basel, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-8677","authenticated-orcid":false,"given":"Laura J.","family":"Gay","sequence":"additional","affiliation":[{"name":"13Wellcome MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik F.P.","family":"Runge","sequence":"additional","affiliation":[{"name":"13Wellcome MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4584-7849","authenticated-orcid":false,"given":"Ilias","family":"Moutsopoulos","sequence":"additional","affiliation":[{"name":"13Wellcome MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-761X","authenticated-orcid":false,"given":"Irina","family":"Mohorianu","sequence":"additional","affiliation":[{"name":"13Wellcome MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-2033","authenticated-orcid":false,"given":"Daniel J.","family":"Hodson","sequence":"additional","affiliation":[{"name":"13Wellcome MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-9391","authenticated-orcid":false,"given":"Pedro","family":"Farinha","sequence":"additional","affiliation":[{"name":"14BC Cancer Research Centre, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-0494","authenticated-orcid":false,"given":"Anja","family":"Mottok","sequence":"additional","affiliation":[{"name":"14BC Cancer Research Centre, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-5947","authenticated-orcid":false,"given":"David W.","family":"Scott","sequence":"additional","affiliation":[{"name":"14BC Cancer Research Centre, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-4516","authenticated-orcid":false,"given":"Jason J.","family":"Pitt","sequence":"additional","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"15Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-6423","authenticated-orcid":false,"given":"Jinmiao","family":"Chen","sequence":"additional","affiliation":[{"name":"16Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3686-5471","authenticated-orcid":false,"given":"Gayatri","family":"Kumar","sequence":"additional","affiliation":[{"name":"17Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-5141","authenticated-orcid":false,"given":"Kasthuri","family":"Kannan","sequence":"additional","affiliation":[{"name":"17Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-8335","authenticated-orcid":false,"given":"Wee Joo","family":"Chng","sequence":"additional","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"11Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-8382","authenticated-orcid":false,"given":"Yen Lin","family":"Chee","sequence":"additional","affiliation":[{"name":"3Department of Haematology-Oncology, National University Health System, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-6410","authenticated-orcid":false,"given":"Siok-Bian","family":"Ng","sequence":"additional","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."},{"name":"2Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0821-6231","authenticated-orcid":false,"given":"Claudio","family":"Tripodo","sequence":"additional","affiliation":[{"name":"18Tumor Immunology Unit, University of Palermo, Palermo, Italy."},{"name":"19IFOM ETS \u2013 The AIRC Institute of Molecular Oncology, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9816-6137","authenticated-orcid":false,"given":"Anand D.","family":"Jeyasekharan","sequence":"additional","affiliation":[{"name":"1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore."},{"name":"3Department of Haematology-Oncology, National University Health System, Singapore, Singapore."},{"name":"4NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"11Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"2025121106472046600_bib1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccell.2020.03.007","article-title":"Intratumor heterogeneity: The rosetta stone of therapy resistance","volume":"37","author":"Marusyk","year":"2020","journal-title":"Cancer Cell"},{"key":"2025121106472046600_bib2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nrc.2017.69","article-title":"Classifying the evolutionary and ecological features of neoplasms","volume":"17","author":"Maley","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"2025121106472046600_bib3","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41571-019-0225-1","article-title":"Genetic alterations and their clinical implications in DLBCL","volume":"16","author":"Miao","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"2025121106472046600_bib4","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1182\/blood-2017-11-742577","article-title":"The MYC oncogene is a global regulator of the immune response","volume":"131","author":"Casey","year":"2018","journal-title":"Blood"},{"key":"2025121106472046600_bib5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/335440a0","article-title":"Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells","volume":"335","author":"Vaux","year":"1988","journal-title":"Nature"},{"key":"2025121106472046600_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ccr.2005.03.037","article-title":"Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice","volume":"7","author":"Cattoretti","year":"2005","journal-title":"Cancer Cell"},{"key":"2025121106472046600_bib7","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1200\/JCO.2011.41.0985","article-title":"Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone","volume":"30","author":"Johnson","year":"2012","journal-title":"J Clin Oncol"},{"key":"2025121106472046600_bib8","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1182\/blood-2012-10-460063","article-title":"MYC\/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from the international DLBCL rituximab-CHOP consortium program","volume":"121","author":"Hu","year":"2013","journal-title":"Blood"},{"key":"2025121106472046600_bib9","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1182\/blood-2012-06-435842","article-title":"MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma","volume":"121","author":"Horn","year":"2013","journal-title":"Blood"},{"key":"2025121106472046600_bib10","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/ni.2428","article-title":"The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry","volume":"13","author":"Dominguez-Sola","year":"2012","journal-title":"Nat Immunol"},{"key":"2025121106472046600_bib11","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1182\/bloodadvances.2020001727","article-title":"Molecular background delineates outcome of double protein expressor diffuse large B-cell lymphoma","volume":"4","author":"Meriranta","year":"2020","journal-title":"Blood Adv"},{"key":"2025121106472046600_bib12","doi-asserted-by":"crossref","first-page":"062104","DOI":"10.1103\/PhysRevE.97.062104","article-title":"Pair correlation functions for identifying spatial correlation in discrete domains","volume":"97","author":"Gavagnin","year":"2018","journal-title":"Phys Rev E"},{"issue":"8","key":"2025121106472046600_bib13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081924","article-title":"Using the R package spatstat to assess inhibitory effects of microregional hypoxia on the infiltration of cancers of the head and neck region by cytotoxic T lymphocytes","volume":"13","author":"Kaufmann","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2025121106472046600_bib14","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1038\/s41598-018-24631-5","article-title":"Prognostic significances of overexpression MYC and\/or BCL2 in R-CHOP-treated diffuse large B-cell lymphoma: a systematic review and meta-analysis","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"2025121106472046600_bib15","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1182\/blood-2016-11-747022","article-title":"Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin\u2013specific clinical impact","volume":"129","author":"Ennishi","year":"2017","journal-title":"Blood"},{"key":"2025121106472046600_bib16","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.3748\/wjg.v21.i8.2433","article-title":"Coexpression of MYC and BCL-2 predicts prognosis in primary gastrointestinal diffuse large B-cell lymphoma","volume":"21","author":"Xia","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2025121106472046600_bib17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1200\/JCO.18.01314","article-title":"Molecular high-grade B-cell lymphoma: defining a poor-risk group that requires different approaches to therapy","volume":"37","author":"Sha","year":"2019","journal-title":"J Clin Oncol"},{"key":"2025121106472046600_bib18","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1038\/leu.2012.83","article-title":"Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the international DLBCL rituximab-CHOP consortium program study","volume":"26","author":"Visco","year":"2012","journal-title":"Leukemia"},{"key":"2025121106472046600_bib19","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal gene signatures in large-B-cell lymphomas","volume":"359","author":"Lenz","year":"2008","journal-title":"N Engl J Med"},{"key":"2025121106472046600_bib20","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1158\/1078-0432.CCR-16-1922","article-title":"Biological and clinical relevance of associated genomic alterations in MYD88 L265P and non-L265P-mutated diffuse large B-cell lymphoma: analysis of 361 cases","volume":"23","author":"Dubois","year":"2017","journal-title":"Clin Cancer Res"},{"key":"2025121106472046600_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/bjh.12045","article-title":"Whole genome expression profiling based on paraffin embedded tissue can be used to classify diffuse large B-cell lymphoma and predict clinical outcome","volume":"159","author":"Barrans","year":"2012","journal-title":"Br J Haematol"},{"key":"2025121106472046600_bib22","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-018-0016-8","article-title":"Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes","volume":"24","author":"Chapuy","year":"2018","journal-title":"Nat Med"},{"key":"2025121106472046600_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cell.2017.09.027","article-title":"Genetic and functional drivers of diffuse large B cell lymphoma","volume":"171","author":"Reddy","year":"2017","journal-title":"Cell"},{"key":"2025121106472046600_bib24","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","article-title":"Genetics and pathogenesis of diffuse large B-cell lymphoma","volume":"378","author":"Schmitz","year":"2018","journal-title":"N Engl J Med"},{"key":"2025121106472046600_bib25","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1200\/JCO.2017.73.3402","article-title":"Obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in previously untreated diffuse large B-cell lymphoma","volume":"35","author":"Vitolo","year":"2017","journal-title":"J Clin Oncol"},{"key":"2025121106472046600_bib26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ccell.2020.03.015","article-title":"A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications","volume":"37","author":"Wright","year":"2020","journal-title":"Cancer Cell"},{"key":"2025121106472046600_bib27","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1038\/s41467-019-12494-x","article-title":"Genetic modification of primary human B cells to model high-grade lymphoma","volume":"10","author":"Caeser","year":"2019","journal-title":"Nat Commun"},{"key":"2025121106472046600_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V86.1.45.bloodjournal86145","article-title":"BCL-6 protein is expressed in germinal-center B cells","volume":"86","author":"Cattoretti","year":"1995","journal-title":"Blood"},{"key":"2025121106472046600_bib29","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/sj.bjc.6605010","article-title":"BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers","volume":"100","author":"Hirata","year":"2009","journal-title":"Br J Cancer"},{"key":"2025121106472046600_bib30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1074-7613(00)00020-0","article-title":"BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control","volume":"13","author":"Shaffer","year":"2000","journal-title":"Immunity"},{"key":"2025121106472046600_bib31","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/modpathol.3800434","article-title":"Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma","volume":"18","author":"Hans","year":"2005","journal-title":"Mod Pathol"},{"key":"2025121106472046600_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"2025121106472046600_bib33","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.ccell.2021.08.011","article-title":"The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma","volume":"39","author":"Steen","year":"2021","journal-title":"Cancer Cell"},{"key":"2025121106472046600_bib34","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/s41556-020-0532-x","article-title":"Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels","volume":"22","author":"Roider","year":"2020","journal-title":"Nat Cell Biol"},{"key":"2025121106472046600_bib35","doi-asserted-by":"crossref","first-page":"E577","DOI":"10.1073\/pnas.1524677113","article-title":"Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1","volume":"113","author":"Dekker","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"2025121106472046600_bib36","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1182\/blood-2011-03-344374","article-title":"PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma","volume":"118","author":"G\u00f3mez-Abad","year":"2011","journal-title":"Blood"},{"key":"2025121106472046600_bib37","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1093\/nar\/gku451","article-title":"SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity","volume":"42","author":"Care","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2025121106472046600_bib38","doi-asserted-by":"crossref","first-page":"9571","DOI":"10.1073\/pnas.90.20.9571","article-title":"Regulation of G1\/S transition by cyclins D2 and D3 in hematopoietic cells","volume":"90","author":"Ando","year":"1993","journal-title":"Proc Natl Acad Sci"},{"key":"2025121106472046600_bib39","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1182\/blood-2003-07-2277","article-title":"Enforced expression of cyclin D2 enhances the proliferative potential of myeloid progenitors, accelerates in vivo myeloid reconstitution, and promotes rescue of mice from lethal myeloablation","volume":"104","author":"Sasaki","year":"2004","journal-title":"Blood"},{"key":"2025121106472046600_bib40","doi-asserted-by":"crossref","first-page":"e00663","DOI":"10.1128\/JVI.00663-18","article-title":"Epstein-barr virus nuclear antigen 3C facilitates cell proliferation by regulating cyclin D2","volume":"92","author":"Pei","year":"2018","journal-title":"J Virol"},{"key":"2025121106472046600_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1200\/JCO.2016.68.2740","article-title":"Relapsed or refractory double-expressor and double-hit lymphomas have inferior progression-free survival after autologous stem-cell transplantation","volume":"35","author":"Herrera","year":"2017","journal-title":"J Clin Oncol"},{"key":"2025121106472046600_bib42","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1200\/JCO.2011.41.4342","article-title":"Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone","volume":"30","author":"Green","year":"2012","journal-title":"J Clin Oncol"},{"key":"2025121106472046600_bib43","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/carcin\/bgz068","article-title":"Genomic pattern of intratumor heterogeneity predicts the risk of progression in early stage diffuse large B-cell lymphoma","volume":"40","author":"Wang","year":"2019","journal-title":"Carcinogenesis"},{"key":"2025121106472046600_bib44","doi-asserted-by":"crossref","first-page":"110713","DOI":"10.1016\/j.celrep.2022.110713","article-title":"A single-cell atlas of diffuse large B cell lymphoma","volume":"39","author":"Ye","year":"2022","journal-title":"Cell Rep"},{"key":"2025121106472046600_bib45","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1038\/sj.leu.2404856","article-title":"Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma","volume":"21","author":"Iqbal","year":"2007","journal-title":"Leukemia"},{"key":"2025121106472046600_bib46","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1158\/1078-0432.CCR-21-2949","article-title":"Genetic subtyping and phenotypic characterization of the immune microenvironment and MYC\/BCL2 double expression reveal heterogeneity in diffuse large B-cell lymphoma","volume":"28","author":"Xu-Monette","year":"2022","journal-title":"Clin Cancer Res"},{"key":"2025121106472046600_bib47","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMoa2115304","article-title":"Polatuzumab vedotin in previously untreated diffuse large B-cell lymphoma","volume":"386","author":"Tilly","year":"2021","journal-title":"N Engl J Med"},{"key":"2025121106472046600_bib48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.blre.2016.09.004","article-title":"High grade B-cell lymphoma with rearrangements of MYC and BCL2 and\/or BCL6: double hit and triple hit lymphomas and double expressing lymphoma","volume":"31","author":"Rosenthal","year":"2017","journal-title":"Blood Rev"},{"key":"2025121106472046600_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1200\/JCO.18.01583","article-title":"Double-hit gene expression signature defines a distinct subgroup of germinal center B-cell-like diffuse large B-cell lymphoma","volume":"37","author":"Ennishi","year":"2019","journal-title":"J Clin Oncol"},{"key":"2025121106472046600_bib50","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1182\/blood-2013-05-498329","article-title":"Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification","volume":"122","author":"Ott","year":"2013","journal-title":"Blood"},{"key":"2025121106472046600_bib51","doi-asserted-by":"crossref","first-page":"e555","DOI":"10.1016\/S1470-2045(15)00005-4","article-title":"Double-hit and double-protein-expression lymphomas: aggressive and refractory lymphomas","volume":"16","author":"Sarkozy","year":"2015","journal-title":"Lancet Oncol"},{"key":"2025121106472046600_bib52","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood-2009-03-212191","article-title":"Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival","volume":"114","author":"Johnson","year":"2009","journal-title":"Blood"},{"key":"2025121106472046600_bib53","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1056\/NEJMoa1616288","article-title":"Tracking the evolution of non\u2013small-cell lung cancer","volume":"376","author":"Jamal-Hanjani","year":"2017","journal-title":"N Engl J Med"},{"key":"2025121106472046600_bib54","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1113205","article-title":"Intratumor heterogeneity and branched evolution revealed by multiregion sequencing","volume":"366","author":"Gerlinger","year":"2012","journal-title":"N Engl J Med"},{"key":"2025121106472046600_bib55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.cell.2017.01.018","article-title":"Clonal heterogeneity and tumor evolution: past, present, and the future","volume":"168","author":"McGranahan","year":"2017","journal-title":"Cell"},{"key":"2025121106472046600_bib56","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1056\/NEJMra1204892","article-title":"The implications of clonal genome evolution for cancer medicine","volume":"368","author":"Aparicio","year":"2013","journal-title":"N Engl J Med"},{"key":"2025121106472046600_bib57","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.cell.2012.02.025","article-title":"Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor","volume":"148","author":"Xu","year":"2012","journal-title":"Cell"},{"key":"2025121106472046600_bib58","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41591-018-0096-5","article-title":"Phenotype molding of stromal cells in the lung tumor microenvironment","volume":"24","author":"Lambrechts","year":"2018","journal-title":"Nat Med"},{"key":"2025121106472046600_bib59","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cell.2018.05.060","article-title":"Single-cell map of diverse immune phenotypes in the breast tumor microenvironment","volume":"174","author":"Azizi","year":"2018","journal-title":"Cell"},{"key":"2025121106472046600_bib60","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.cell.2021.03.009","article-title":"Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes","volume":"184","author":"Dentro","year":"2021","journal-title":"Cell"},{"key":"2025121106472046600_bib61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s43018-019-0002-1","article-title":"Intratumor heterogeneity reflects clinical disease course","volume":"1","author":"Iacobuzio-Donahue","year":"2020","journal-title":"Nat Cancer"},{"key":"2025121106472046600_bib62","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"2025121106472046600_bib63","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1182\/bloodadvances.2018020602","article-title":"PD-L1 and tumor-associated macrophages in de novo DLBCL","volume":"3","author":"McCord","year":"2019","journal-title":"Blood Adv"},{"key":"2025121106472046600_bib64","doi-asserted-by":"crossref","first-page":"e13366","DOI":"10.15252\/emmm.202013366","article-title":"Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer","volume":"13","author":"Hoppe","year":"2021","journal-title":"EMBO Mol Med"},{"key":"2025121106472046600_bib65","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.3390\/ijms21113828","article-title":"CSI NGS portal: an online platform for automated NGS data analysis and sharing","volume":"21","author":"An","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025121106472046600_bib66","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/s41596-021-00506-4","article-title":"Genetic manipulation and immortalized culture of ex vivo primary human germinal center B cells","volume":"16","author":"Caeser","year":"2021","journal-title":"Nat Protoc"},{"key":"2025121106472046600_bib67","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"2025121106472046600_bib68","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1093\/bioinformatics\/btab209","article-title":"ShinyCell: simple and sharable visualization of single-cell gene expression data","volume":"37","author":"Ouyang","year":"2021","journal-title":"Bioinformatics"},{"key":"2025121106472046600_bib69","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"2025121106472046600_bib70","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol"},{"key":"2025121106472046600_bib71","doi-asserted-by":"crossref","first-page":"ELIXIR","DOI":"10.12688\/f1000research.24956.2","article-title":"gprofiler2 \u2013 an R package for gene list functional enrichment analysis and namespace conversion toolset g:Profiler [version 2; peer review: 2 approved]","volume":"9","author":"Kolberg","year":"2020","journal-title":"F1000Research"},{"key":"2025121106472046600_bib72","doi-asserted-by":"crossref","first-page":"D661","DOI":"10.1093\/nar\/gkx1064","article-title":"WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research","volume":"46","author":"Slenter","year":"2017","journal-title":"Nucleic Acids Res"}],"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/doi\/10.1158\/2159-8290.CD-22-0998\/3311442\/cd-22-0998.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/13\/5\/1144\/3328780\/1144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/13\/5\/1144\/3328780\/1144.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:47:40Z","timestamp":1765453660000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/13\/5\/1144\/726201\/Patterns-of-Oncogene-Coexpression-at-Single-Cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":72,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,4,18]]},"published-print":{"date-parts":[[2023,5,4]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-22-0998","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1158\/2159-8290.30859191","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758735","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758723","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758711","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859194","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758729","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758732","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758738","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758720","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1158\/2159-8290.22758729.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758717","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22653898.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758732.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22653898","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758735.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6605362","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758738.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6605362.v2","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758720.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758714","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758723.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22653901","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22653901.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6605362.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758714.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758717.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.22758711.v1","asserted-by":"object"}]},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]}}}