{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:32:55Z","timestamp":1792787575190,"version":"4.5.0"},"reference-count":50,"publisher":"American Association for Cancer Research (AACR)","issue":"7","funder":[{"DOI":"10.13039\/100000953","name":"Alliance for Cancer Gene Therapy","doi-asserted-by":"crossref","award":["Investigator Award in Cell and Gene Therapy for Cancer"],"award-info":[{"award-number":["Investigator Award in Cell and Gene Therapy for Cancer"]}],"id":[{"id":"10.13039\/100000953","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015338","name":"Cancer Moonshot","doi-asserted-by":"crossref","award":["U54 CA244711"],"award-info":[{"award-number":["U54 CA244711"]}],"id":[{"id":"10.13039\/100015338","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute","award":["F31 CA274961"],"award-info":[{"award-number":["F31 CA274961"]}]},{"name":"National Cancer Institute","award":["P01 CA214278"],"award-info":[{"award-number":["P01 CA214278"]}]},{"name":"National Cancer Institute","award":["P30 CA016520-42"],"award-info":[{"award-number":["P30 CA016520-42"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["U01 AG066100"],"award-info":[{"award-number":["U01 AG066100"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001299","name":"Prevent Cancer Foundation","doi-asserted-by":"crossref","award":["Young Investigator Award"],"award-info":[{"award-number":["Young Investigator Award"]}],"id":[{"id":"10.13039\/100001299","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"crossref","award":["Tactical Award"],"award-info":[{"award-number":["Tactical Award"]}],"id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001384","name":"Samuel Waxman Cancer Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001384","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Chimeric antigen receptor (CAR) T cell therapy has shown promise in treating hematologic cancers, but resistance is common and efficacy is limited in solid tumors. We found that CAR T cells autonomously propagate epigenetically programmed type I interferon signaling through chronic stimulation, which hampers antitumor function. EGR2 transcriptional regulator knockout not only blocks this type I interferon\u2013mediated inhibitory program but also independently expands early memory CAR T cells with improved efficacy against liquid and solid tumors. The protective effect of EGR2 deletion in CAR T cells against chronic antigen-induced exhaustion can be overridden by interferon-\u03b2 exposure, suggesting that EGR2 ablation suppresses dysfunction by inhibiting type I interferon signaling. Finally, a refined EGR2 gene signature is a biomarker for type I interferon\u2013associated CAR T cell failure and shorter patient survival. These findings connect prolonged CAR T cell activation with deleterious immunoinflammatory signaling and point to an EGR2\u2013type I interferon axis as a therapeutically amenable biological system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>To improve CAR T cell therapy outcomes, modulating molecular determinants of CAR T cell\u2013intrinsic resistance is crucial. Editing the gene encoding the EGR2 transcriptional regulator renders CAR T cells impervious to type I interferon pathway\u2013induced dysfunction and improves memory differentiation, thereby addressing major barriers to progress for this emerging class of cancer immunotherapies.<\/jats:p>\n                    <jats:p>This article is highlighted in the In This Issue feature, p. 1501<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-22-1175","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T09:24:40Z","timestamp":1686216280000},"page":"1636-1655","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell\u2013Intrinsic Dysfunction"],"prefix":"10.1158","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-8083","authenticated-orcid":false,"given":"In-Young","family":"Jung","sequence":"first","affiliation":[{"name":"1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-4661","authenticated-orcid":false,"given":"Robert L.","family":"Bartoszek","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6585-8839","authenticated-orcid":false,"given":"Andrew J.","family":"Rech","sequence":"additional","affiliation":[{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"5Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"6Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-9659","authenticated-orcid":false,"given":"Sierra M.","family":"Collins","sequence":"additional","affiliation":[{"name":"6Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"7Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"8Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"9Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2665-5414","authenticated-orcid":false,"given":"Soon-Keat","family":"Ooi","sequence":"additional","affiliation":[{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3213-093X","authenticated-orcid":false,"given":"Erik F.","family":"Williams","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-8268","authenticated-orcid":false,"given":"Caitlin R.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-738X","authenticated-orcid":false,"given":"Vivek","family":"Narayan","sequence":"additional","affiliation":[{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"5Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-7968","authenticated-orcid":false,"given":"Naomi B.","family":"Haas","sequence":"additional","affiliation":[{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"5Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-9836","authenticated-orcid":false,"given":"Noelle V.","family":"Frey","sequence":"additional","affiliation":[{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"5Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-4060","authenticated-orcid":false,"given":"Elizabeth O.","family":"Hexner","sequence":"additional","affiliation":[{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"5Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-2251","authenticated-orcid":false,"given":"Donald L.","family":"Siegel","sequence":"additional","affiliation":[{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-5943","authenticated-orcid":false,"given":"Gabriela","family":"Plesa","sequence":"additional","affiliation":[{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6333-9536","authenticated-orcid":false,"given":"David L.","family":"Porter","sequence":"additional","affiliation":[{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"5Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3168-5140","authenticated-orcid":false,"given":"Adrian","family":"Cantu","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-9322","authenticated-orcid":false,"given":"John K.","family":"Everett","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-0760","authenticated-orcid":false,"given":"Sonia","family":"Guedan","sequence":"additional","affiliation":[{"name":"10Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-4400","authenticated-orcid":false,"given":"Shelley L.","family":"Berger","sequence":"additional","affiliation":[{"name":"6Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"7Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"8Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"9Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-4056","authenticated-orcid":false,"given":"Frederic D.","family":"Bushman","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2167-750X","authenticated-orcid":false,"given":"Friederike","family":"Herbst","sequence":"additional","affiliation":[{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7900-8993","authenticated-orcid":false,"given":"Joseph A.","family":"Fraietta","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"2Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."},{"name":"4Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"2025121106565240200_bib1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41591-018-0010-1","article-title":"Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia","volume":"24","author":"Fraietta","year":"2018","journal-title":"Nat Med"},{"key":"2025121106565240200_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41586-018-0178-z","article-title":"Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells","volume":"558","author":"Fraietta","year":"2018","journal-title":"Nature"},{"key":"2025121106565240200_bib3","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1182\/bloodadvances.2019000219","article-title":"Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T cell therapy","volume":"3","author":"Shah","year":"2019","journal-title":"Blood Adv"},{"key":"2025121106565240200_bib4","doi-asserted-by":"crossref","first-page":"eaaz3223","DOI":"10.1126\/sciadv.aaz3223","article-title":"Chimeric antigen receptor signaling: functional consequences and design implications","volume":"6","author":"Lindner","year":"2020","journal-title":"Sci Adv"},{"key":"2025121106565240200_bib5","first-page":"4038","article-title":"Fueling chimeric antigen receptor T cells with cytokines","volume":"10","author":"Jin","year":"2020","journal-title":"Am J Cancer Res"},{"key":"2025121106565240200_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ccell.2015.09.004","article-title":"Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells","volume":"28","author":"Zhao","year":"2015","journal-title":"Cancer Cell"},{"key":"2025121106565240200_bib7","doi-asserted-by":"crossref","first-page":"1997385","DOI":"10.1080\/2162402X.2021.1997385","article-title":"Cancer-specific type-I interferon receptor signaling promotes cancer stemness and effector CD8+ T cell exhaustion","volume":"10","author":"Gong","year":"2021","journal-title":"Oncoimmunology"},{"key":"2025121106565240200_bib8","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1038\/s41467-020-17011-z","article-title":"Oncolytic virus-derived type I interferon restricts CAR T cell therapy","volume":"11","author":"Evgin","year":"2020","journal-title":"Nat Commun"},{"key":"2025121106565240200_bib9","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1158\/0008-5472.CAN-18-0030","article-title":"CRISPR\/Cas9-mediated knockout of DGK improves antitumor activities of human T cells","volume":"78","author":"Jung","year":"2018","journal-title":"Cancer Res"},{"key":"2025121106565240200_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nm.3838","article-title":"4\u20131BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors","volume":"21","author":"Long","year":"2015","journal-title":"Nat Med"},{"key":"2025121106565240200_bib11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41586-019-1805-z","article-title":"c-Jun overexpression in CAR T cells induces exhaustion resistance","volume":"576","author":"Lynn","year":"2019","journal-title":"Nature"},{"key":"2025121106565240200_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2018.11.043","article-title":"Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma","volume":"176","author":"Li","year":"2019","journal-title":"Cell"},{"key":"2025121106565240200_bib13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-018-0694-x","article-title":"Lineage tracking reveals dynamic relationships of T cells in colorectal cancer","volume":"564","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"2025121106565240200_bib14","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1158\/2159-8290.CD-20-1677","article-title":"Integrative bulk and single-cell profiling of premanufacture T cell populations reveals factors mediating long-term persistence of CAR T cell therapy","volume":"11","author":"Chen","year":"2021","journal-title":"Cancer Discov"},{"key":"2025121106565240200_bib15","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1038\/s41467-021-23044-9","article-title":"Antigen-driven EGR2 expression is required for exhausted CD8(+) T cell stability and maintenance","volume":"12","author":"Wagle","year":"2021","journal-title":"Nat Commun"},{"key":"2025121106565240200_bib16","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1084\/jem.20120342","article-title":"Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo","volume":"209","author":"Zheng","year":"2012","journal-title":"J Exp Med"},{"key":"2025121106565240200_bib17","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41591-022-01726-1","article-title":"PSMA-targeting TGFbeta-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial","volume":"28","author":"Narayan","year":"2022","journal-title":"Nat Med"},{"key":"2025121106565240200_bib18","doi-asserted-by":"crossref","first-page":"16484","DOI":"10.1073\/pnas.1417215111","article-title":"EGR2 is critical for peripheral naive T cell differentiation and the T cell response to influenza","volume":"111","author":"Du","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025121106565240200_bib19","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20171352","article-title":"ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8(+) T cell fates","volume":"215","author":"Guan","year":"2018","journal-title":"J Exp Med"},{"key":"2025121106565240200_bib20","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.4049\/jimmunol.1501896","article-title":"Cutting edge: Foxp1 controls naive CD8+ T cell quiescence by simultaneously repressing key pathways in cellular metabolism and cell cycle progression","volume":"196","author":"Wei","year":"2016","journal-title":"J Immunol"},{"key":"2025121106565240200_bib21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ccell.2019.12.014","article-title":"THEMIS-SHP1 recruitment by 4\u20131BB tunes LCK-mediated priming of chimeric antigen receptor-redirected T cells","volume":"37","author":"Sun","year":"2020","journal-title":"Cancer Cell"},{"key":"2025121106565240200_bib22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.molimm.2013.03.006","article-title":"Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy","volume":"55","author":"Zheng","year":"2013","journal-title":"Mol Immunol"},{"key":"2025121106565240200_bib23","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.cell.2018.10.038","article-title":"Defining T cell states associated with response to checkpoint immunotherapy in melanoma","volume":"175","author":"Sade-Feldman","year":"2018","journal-title":"Cell"},{"key":"2025121106565240200_bib24","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ccell.2022.06.001","article-title":"Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence","volume":"40","author":"Belk","year":"2022","journal-title":"Cancer Cell"},{"key":"2025121106565240200_bib25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41590-021-00964-8","article-title":"BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells","volume":"22","author":"Seo","year":"2021","journal-title":"Nat Immunol"},{"key":"2025121106565240200_bib26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41591-018-0290-5","article-title":"Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency","volume":"25","author":"Feucht","year":"2019","journal-title":"Nat Med"},{"key":"2025121106565240200_bib27","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.immuni.2017.11.021","article-title":"Transcription factor IRF4 promotes CD8(+) T cell exhaustion and limits the development of memory-like T cells during chronic infection","volume":"47","author":"Man","year":"2017","journal-title":"Immunity"},{"key":"2025121106565240200_bib28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.2834","article-title":"The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells","volume":"15","author":"Kurachi","year":"2014","journal-title":"Nat Immunol"},{"key":"2025121106565240200_bib29","doi-asserted-by":"crossref","first-page":"15419","DOI":"10.1073\/pnas.1206370109","article-title":"Activator protein 1 suppresses antitumor T cell function via the induction of programmed death 1","volume":"109","author":"Xiao","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025121106565240200_bib30","doi-asserted-by":"crossref","first-page":"12410","DOI":"10.1073\/pnas.1905675116","article-title":"TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion","volume":"116","author":"Seo","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025121106565240200_bib31","doi-asserted-by":"crossref","first-page":"eabh0272","DOI":"10.1126\/scitranslmed.abh0272","article-title":"Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity","volume":"13","author":"Prinzing","year":"2021","journal-title":"Sci Transl Med"},{"key":"2025121106565240200_bib32","doi-asserted-by":"crossref","first-page":"eabj2820","DOI":"10.1126\/sciadv.abj2820","article-title":"Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL","volume":"8","author":"Bai","year":"2022","journal-title":"Sci Adv"},{"key":"2025121106565240200_bib33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.immuni.2018.11.014","article-title":"Checkpoint blockade immunotherapy induces dynamic changes in PD-1-CD8+ tumor-infiltrating T cells","volume":"50","author":"Kurtulus","year":"2019","journal-title":"Immunity"},{"key":"2025121106565240200_bib34","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/s41590-022-01152-y","article-title":"Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells","volume":"23","author":"Sumida","year":"2022","journal-title":"Nat Immunol"},{"key":"2025121106565240200_bib35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1182\/blood-2011-07-366419","article-title":"Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells","volume":"119","author":"Terakura","year":"2012","journal-title":"Blood"},{"key":"2025121106565240200_bib36","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1128\/JVI.77.8.4911-4927.2003","article-title":"Viral persistence alters CD8 T cell immunodominance and tissue distribution and results in distinct stages of functional impairment","volume":"77","author":"Wherry","year":"2003","journal-title":"J Virol"},{"key":"2025121106565240200_bib37","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1172\/JCI125423","article-title":"CD19 CAR T cell product and disease attributes predict leukemia remission durability","volume":"129","author":"Finney","year":"2019","journal-title":"J Clin Invest"},{"key":"2025121106565240200_bib38","doi-asserted-by":"crossref","first-page":"e121322","DOI":"10.1172\/jci.insight.121322","article-title":"4\u20131BB enhancement of CAR T function requires NF-kappaB and TRAFs","volume":"3","author":"Li","year":"2018","journal-title":"JCI Insight"},{"key":"2025121106565240200_bib39","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.187.11.1849","article-title":"CD28-independent, TRAF2-dependent costimulation of resting T cells by 4\u20131BB ligand","volume":"187","author":"Saoulli","year":"1998","journal-title":"J Exp Med"},{"key":"2025121106565240200_bib40","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.molimm.2009.12.002","article-title":"Direct binding of TRAF2 and TRAF6 to TICAM-1\/TRIF adaptor participates in activation of the Toll-like receptor 3\/4 pathway","volume":"47","author":"Sasai","year":"2010","journal-title":"Mol Immunol"},{"key":"2025121106565240200_bib41","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.febslet.2006.01.091","article-title":"A signal through 4-1BB ligand inhibits receptor for activation of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis by increasing interferon (IFN)-beta production","volume":"580","author":"Shin","year":"2006","journal-title":"FEBS Lett"},{"key":"2025121106565240200_bib42","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.1235214","article-title":"Persistent LCMV infection is controlled by blockade of type I interferon signaling","volume":"340","author":"Teijaro","year":"2013","journal-title":"Science"},{"key":"2025121106565240200_bib43","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.1235208","article-title":"Blockade of chronic type I interferon signaling to control persistent LCMV infection","volume":"340","author":"Wilson","year":"2013","journal-title":"Science"},{"key":"2025121106565240200_bib44","doi-asserted-by":"crossref","first-page":"eaai8593","DOI":"10.1126\/sciimmunol.aai8593","article-title":"The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness","volume":"1","author":"Wu","year":"2016","journal-title":"Sci Immunol"},{"key":"2025121106565240200_bib45","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1084\/jem.20160553","article-title":"Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation","volume":"214","author":"Miao","year":"2017","journal-title":"J Exp Med"},{"key":"2025121106565240200_bib46","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4049\/jimmunol.1700453","article-title":"Of mice, dirty mice, and men: using mice to understand human immunology","volume":"199","author":"Masopust","year":"2017","journal-title":"J Immunol"},{"key":"2025121106565240200_bib47","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.ymthe.2018.05.003","article-title":"Dominant-negative TGF-beta receptor enhances PSMA-targeted human CAR T cell proliferation and augments prostate cancer eradication","volume":"26","author":"Kloss","year":"2018","journal-title":"Mol Ther"},{"key":"2025121106565240200_bib48","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/mt.2009.83","article-title":"Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo","volume":"17","author":"Milone","year":"2009","journal-title":"Mol Ther"},{"key":"2025121106565240200_bib49","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.ymthe.2019.07.015","article-title":"Phase I study of lentiviral-transduced chimeric antigen receptor-modified T cells recognizing mesothelin in advanced solid cancers","volume":"27","author":"Haas","year":"2019","journal-title":"Mol Ther"},{"key":"2025121106565240200_bib50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/crispr.2021.0113","article-title":"Inference of CRISPR edits from sanger trace data","volume":"5","author":"Conant","year":"2022","journal-title":"CRISPR J"}],"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/doi\/10.1158\/2159-8290.CD-22-1175\/3339561\/cd-22-1175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/13\/7\/1636\/3345659\/1636.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/13\/7\/1636\/3345659\/1636.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:57:08Z","timestamp":1765454228000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/13\/7\/1636\/727605\/Type-I-Interferon-Signaling-via-the-EGR2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4,3]]},"published-print":{"date-parts":[[2023,7,7]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-22-1175","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1158\/2159-8290.27025298.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391311.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391287.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391311","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391278","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025286","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391335","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641395.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025262","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391281.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025292.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859275","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859299","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641371","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641395","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641374","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641398","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025289","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025301.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391299","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025265","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859272","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391305","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859296","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391329","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391299.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391278.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641377","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391290.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391272.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025280","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641389.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025286.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859269","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391305.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025280.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025268.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391281","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641374.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025277.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025271.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025283","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859293","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025262.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859266","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641365.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391329.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641380","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391290","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641359","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025298","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025274","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859290","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641398.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025295.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859263","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859287","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391269.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641380.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641386","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641401.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391287","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025277","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641392.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391317","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391296.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859284","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641362","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641365","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391272","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641389","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391296","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025268","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859260","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025292","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641371.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025289.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025283.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641386.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025274.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391326.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641368","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641377.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641401","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391335.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025265.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641368.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391269","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025295","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391326","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391317.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859281","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025271","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641359.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.30859278","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641362.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27025301","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641392","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1158\/2159-8290.23641377","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6686780.v2","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391317","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391335.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641359.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641380","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391299.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391287","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391290","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641395.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641362.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641374","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641398","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391326.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641368.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641371.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641401","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641368","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391326","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391269","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641386.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641377.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641395","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641380.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641371","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391296","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391272","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641389.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641389","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391305","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391329","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6686780","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391290.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391296.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641392","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391299","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.6686780.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641401.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391317.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391311.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391305.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641365","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391269.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641359","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641398.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391335","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641392.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391278","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391311","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391281.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391287.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641386","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641362","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391329.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391281","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641374.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23641365.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391278.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.23391272.v1","asserted-by":"object"}]},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]}}}