{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:58:41Z","timestamp":1765454321490,"version":"3.46.0"},"reference-count":10,"publisher":"American Association for Cancer Research (AACR)","issue":"6","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,2]]},"abstract":"<jats:sec>\n                    <jats:title>Summary:<\/jats:title>\n                    <jats:p>Carpenter and colleagues analyze organ donors to find that pancreatic intraepithelial neoplasia (PanIN), the precursor lesions of pancreatic ductal adenocarcinoma, are highly prevalent in the average healthy adult starting from a young age. Why these precursor lesions do not progress to cancer in most people is a mystery.<\/jats:p>\n                    <jats:p>See related article by Carpenter et al., p. 1324 (1).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-23-0332","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T09:54:17Z","timestamp":1685699657000},"page":"1288-1290","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic Neoplasms Are Frighteningly Common: A Role for Immune Surveillance?"],"prefix":"10.1158","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-9977","authenticated-orcid":false,"given":"Megan T.","family":"Hoffman","sequence":"first","affiliation":[{"name":"1Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts."},{"name":"2Department of Immunology, Harvard Medical School, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-363X","authenticated-orcid":false,"given":"Stephanie K.","family":"Dougan","sequence":"additional","affiliation":[{"name":"1Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts."},{"name":"2Department of Immunology, Harvard Medical School, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"2025121106482395600_bib1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1158\/2159-8290.CD-23-0013","article-title":"Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions","volume":"13","author":"Carpenter","year":"2023","journal-title":"Cancer 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