{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:03:10Z","timestamp":1793430190215,"version":"4.5.0"},"reference-count":34,"publisher":"American Association for Cancer Research (AACR)","issue":"10","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":98,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["CC2008"],"award-info":[{"award-number":["CC2008"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["CC2008"],"award-info":[{"award-number":["CC2008"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["CC2008"],"award-info":[{"award-number":["CC2008"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["CC2041"],"award-info":[{"award-number":["CC2041"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["CC2041"],"award-info":[{"award-number":["CC2041"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["CC2041"],"award-info":[{"award-number":["CC2041"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001645","name":"Boehringer Ingelheim Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP210028"],"award-info":[{"award-number":["RP210028"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RP150154"],"award-info":[{"award-number":["RP150154"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["TRACERx"],"award-info":[{"award-number":["TRACERx"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C11496\/A17786"],"award-info":[{"award-number":["C11496\/A17786"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C11496\/A30025"],"award-info":[{"award-number":["C11496\/A30025"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RP\/EA\/180007"],"award-info":[{"award-number":["RP\/EA\/180007"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF 20-157"],"award-info":[{"award-number":["BCRF 20-157"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009730","name":"Stand Up To Cancer","doi-asserted-by":"publisher","award":["SU2C-AACR-DT23-17"],"award-info":[{"award-number":["SU2C-AACR-DT23-17"]}],"id":[{"id":"10.13039\/100009730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["FP7-THESEUS-617844"],"award-info":[{"award-number":["FP7-THESEUS-617844"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["FP7-PloidyNet 607722"],"award-info":[{"award-number":["FP7-PloidyNet 607722"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["PROTEUS 835297"],"award-info":[{"award-number":["PROTEUS 835297"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["Chromavision 665233"],"award-info":[{"award-number":["Chromavision 665233"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009756","name":"Sarcoma UK","doi-asserted-by":"publisher","award":["SUKG01.2018"],"award-info":[{"award-number":["SUKG01.2018"]}],"id":[{"id":"10.13039\/100009756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011719","name":"Bone Cancer Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011719","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["18387"],"award-info":[{"award-number":["18387"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["RCCCEA-Nov23\/100003"],"award-info":[{"award-number":["RCCCEA-Nov23\/100003"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR210006"],"award-info":[{"award-number":["RR210006"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic gains leading to complex copy number states, using single-sample bulk whole-genome sequencing data. By applying GRITIC to 6,091 tumors, we found that non-parsimonious evolution is frequent in the formation of complex copy number states in genome-doubled tumors. We measured chromosomal instability before and after genome duplication in human tumors and found that late genome doubling was followed by an increase in the rate of copy number gain. Copy number gains often accumulate as punctuated bursts, commonly after genome doubling. We infer that genome duplications typically affect the landscape of copy number losses, while only minimally impacting copy number gains. In summary, GRITIC is a novel copy number gain timing framework that permits the analysis of copy number evolution in chromosomally unstable tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>Complex genomic gains are associated with whole-genome duplications, which are frequent across tumors, span a large fraction of their genomes, and are linked to poorer outcomes. GRITIC infers when these gains occur during tumor development, which will help to identify the genetic events that drive tumor evolution.<\/jats:p>\n                    <jats:p>See related commentary by Taylor, p. 1766<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-23-1249","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T09:07:01Z","timestamp":1719652021000},"page":"1810-1822","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The History of Chromosomal Instability in Genome-Doubled Tumors"],"prefix":"10.1158","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-9047","authenticated-orcid":false,"given":"Toby M.","family":"Baker","sequence":"first","affiliation":[{"name":"The Francis Crick Institute, London, United Kingdom. 1"},{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2"},{"name":"Department of Medicine, University of California Los Angeles, Los Angeles, California. 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-1961","authenticated-orcid":false,"given":"Siqi","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0238-682X","authenticated-orcid":false,"given":"Andrew R.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-5884","authenticated-orcid":false,"given":"Tom","family":"Lesluyes","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, London, United Kingdom. 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5420-4362","authenticated-orcid":false,"given":"Haixi","family":"Yan","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, London, United Kingdom. 1"},{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-6885","authenticated-orcid":false,"given":"Huw A.","family":"Ogilvie","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1533-3334","authenticated-orcid":false,"given":"Annelien","family":"Verfaillie","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, London, United Kingdom. 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-9729","authenticated-orcid":false,"given":"Stefan","family":"Dentro","sequence":"additional","affiliation":[{"name":"Division of AI in Oncology, German Cancer Research Centre DKFZ, Heidelberg, Germany. 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-5023","authenticated-orcid":false,"given":"Amy L.","family":"Bowes","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, London, United Kingdom. 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-4105","authenticated-orcid":false,"given":"Nischalan","family":"Pillay","sequence":"additional","affiliation":[{"name":"Research Department of Pathology, Cancer Institute, University College London, London, United Kingdom. 5"},{"name":"Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, United Kingdom. 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-1303","authenticated-orcid":false,"given":"Adrienne M.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Research Department of Pathology, Cancer Institute, University College London, London, United Kingdom. 5"},{"name":"Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, United Kingdom. 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-3018","authenticated-orcid":false,"given":"Charles","family":"Swanton","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, London, United Kingdom. 1"},{"name":"Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, United Kingdom. 7"},{"name":"Department of Oncology, University College London Hospitals, London, United Kingdom. 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-0022","authenticated-orcid":false,"given":"Paul T.","family":"Spellman","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Los Angeles, Los Angeles, California. 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-2348","authenticated-orcid":false,"given":"Maxime","family":"Tarabichi","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, London, United Kingdom. 1"},{"name":"Institute for Interdisciplinary Research (IRIBHM), Universit\u00e9 Libre de Bruxelles, Brussels, Belgium. 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-1949","authenticated-orcid":false,"given":"Peter","family":"Van Loo","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, London, United Kingdom. 1"},{"name":"Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2"},{"name":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. 10"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"2026041309543111800_bib1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/ng.2760","article-title":"Pan-cancer patterns of somatic copy number alteration","volume":"45","author":"Zack","year":"2013","journal-title":"Nat Genet"},{"key":"2026041309543111800_bib2","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1242\/jcs.039537","article-title":"The consequences of tetraploidy and aneuploidy","volume":"121","author":"Storchova","year":"2008","journal-title":"J Cell Sci"},{"key":"2026041309543111800_bib3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1126\/science.aau3879","article-title":"Somatic mutant clones colonize the human esophagus with age","volume":"362","author":"Martincorena","year":"2018","journal-title":"Science"},{"key":"2026041309543111800_bib4","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.aaa6806","article-title":"Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin","volume":"348","author":"Martincorena","year":"2015","journal-title":"Science"},{"key":"2026041309543111800_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.aba8347","article-title":"Extensive heterogeneity in somatic mutation and selection in the human bladder","volume":"370","author":"Lawson","year":"2020","journal-title":"Science"},{"key":"2026041309543111800_bib6","doi-asserted-by":"crossref","first-page":"13409","DOI":"10.1073\/pnas.1415287111","article-title":"Single cell sequencing reveals low levels of aneuploidy across mammalian tissues","volume":"111","author":"Knouse","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026041309543111800_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41576-019-0171-x","article-title":"Context is everything: aneuploidy in cancer","volume":"21","author":"Ben-David","year":"2020","journal-title":"Nat Rev Genet"},{"key":"2026041309543111800_bib8","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41588-018-0165-1","article-title":"Genome doubling shapes the evolution and prognosis of advanced cancers","volume":"50","author":"Bielski","year":"2018","journal-title":"Nat Genet"},{"key":"2026041309543111800_bib9","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1158\/0008-5472.CAN-21-2065","article-title":"Whole-genome duplication shapes the aneuploidy landscape of human cancers","volume":"82","author":"Prasad","year":"2022","journal-title":"Cancer Res"},{"key":"2026041309543111800_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41586-020-2698-6","article-title":"Pervasive chromosomal instability and karyotype order in tumour evolution","volume":"587","author":"Watkins","year":"2020","journal-title":"Nature"},{"key":"2026041309543111800_bib11","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature08136","article-title":"A mechanism linking extra centrosomes to chromosomal instability","volume":"460","author":"Ganem","year":"2009","journal-title":"Nature"},{"key":"2026041309543111800_bib12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-022-04578-4","article-title":"Genetic instability from a single S phase after whole-genome duplication","volume":"604","author":"Gemble","year":"2022","journal-title":"Nature"},{"key":"2026041309543111800_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1158\/2159-8290.CD-11-0028","article-title":"Temporal dissection of tumorigenesis in primary cancers","volume":"1","author":"Durinck","year":"2011","journal-title":"Cancer Discov"},{"key":"2026041309543111800_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13059-018-1476-3","article-title":"Timing somatic events in the evolution of cancer","volume":"19","author":"Jolly","year":"2018","journal-title":"Genome Biol"},{"key":"2026041309543111800_bib15","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.cell.2012.04.023","article-title":"The life history of 21 breast cancers","volume":"149","author":"Nik-Zainal","year":"2012","journal-title":"Cell"},{"key":"2026041309543111800_bib16","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1093\/bioinformatics\/btt546","article-title":"Methods and challenges in timing chromosomal abnormalities within cancer samples","volume":"29","author":"Purdom","year":"2013","journal-title":"Bioinformatics"},{"key":"2026041309543111800_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-019-1907-7","article-title":"The evolutionary history of 2,658 cancers","volume":"578","author":"Gerstung","year":"2020","journal-title":"Nature"},{"key":"2026041309543111800_bib18","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s43018-023-00533-y","article-title":"Inferring early genetic progression in cancers with unobtainable premalignant disease","volume":"4","author":"Leshchiner","year":"2023","journal-title":"Nat Cancer"},{"key":"2026041309543111800_bib19","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1038\/s41467-024-46414-5","article-title":"Evolving copy number gains promote tumor expansion and bolster mutational diversification","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"2026041309543111800_bib20","doi-asserted-by":"crossref","first-page":"btae281","DOI":"10.1093\/bioinformatics\/btae281","article-title":"AmplificationTimeR: an R package for timing sequential amplification events","volume":"40","author":"Jakobsdottir","year":"2024","journal-title":"Bioinformatics"},{"key":"2026041309543111800_bib21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"ICGC\/TCGA Pan-Cancer Analysis of Whole Genomes Consortium","year":"2020","journal-title":"Nature"},{"key":"2026041309543111800_bib22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-019-1689-y","article-title":"Pan-cancer whole-genome analyses of metastatic solid tumours","volume":"575","author":"Priestley","year":"2019","journal-title":"Nature"},{"key":"2026041309543111800_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41588-021-01005-8","article-title":"Biallelic mutations in cancer genomes reveal local mutational determinants","volume":"54","author":"Demeulemeester","year":"2022","journal-title":"Nat Genet"},{"key":"2026041309543111800_bib24","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1101\/gr.118414.110","article-title":"Estimation of rearrangement phylogeny for cancer genomes","volume":"22","author":"Greenman","year":"2012","journal-title":"Genome Res"},{"key":"2026041309543111800_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1158\/2159-8290.CD-13-0285","article-title":"Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution","volume":"4","author":"Dewhurst","year":"2014","journal-title":"Cancer Discov"},{"key":"2026041309543111800_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41588-020-0584-7","article-title":"Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution","volume":"52","author":"L\u00f3pez","year":"2020","journal-title":"Nat Genet"},{"key":"2026041309543111800_bib27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.cell.2018.02.020","article-title":"Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx renal","volume":"173","author":"Mitchell","year":"2018","journal-title":"Cell"},{"key":"2026041309543111800_bib28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cell.2017.12.007","article-title":"Multiclonal invasion in breast tumors identified by topographic single cell sequencing","volume":"172","author":"Casasent","year":"2018","journal-title":"Cell"},{"key":"2026041309543111800_bib29","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.celrep.2015.06.065","article-title":"Dynamics of tumor heterogeneity derived from clonal karyotypic evolution","volume":"12","author":"Laughney","year":"2015","journal-title":"Cell Rep"},{"key":"2026041309543111800_bib30","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.cell.2013.10.011","article-title":"Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome","volume":"155","author":"Davoli","year":"2013","journal-title":"Cell"},{"key":"2026041309543111800_bib31","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s43018-023-00711-y","article-title":"Aneuploidy and complex genomic rearrangements in cancer evolution","volume":"5","author":"Baker","year":"2024","journal-title":"Nat Cancer"},{"key":"2026041309543111800_bib32","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/ng.3441","article-title":"Clock-like mutational processes in human somatic cells","volume":"47","author":"Alexandrov","year":"2015","journal-title":"Nat Genet"},{"key":"2026041309543111800_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41586-023-06054-z","article-title":"Pan-cancer whole-genome comparison of primary and metastatic solid tumours","volume":"618","author":"Mart\u00ednez-Jim\u00e9nez","year":"2023","journal-title":"Nature"},{"key":"2026041309543111800_bib34","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1038\/ncomms5114","article-title":"A fast and unbiased procedure to randomize ecological binary matrices with fixed row and column totals","volume":"5","author":"Strona","year":"2014","journal-title":"Nat Commun"}],"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/doi\/10.1158\/2159-8290.CD-23-1249\/3471015\/cd-23-1249.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/doi\/10.1158\/2159-8290.CD-23-1249\/3484772\/cd-23-1249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/14\/10\/1810\/3500432\/cd-23-1249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/14\/10\/1810\/3500432\/cd-23-1249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:54:45Z","timestamp":1776088485000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/14\/10\/1810\/748591\/The-History-of-Chromosomal-Instability-in-Genome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,6,28]]},"published-print":{"date-parts":[[2024,10,4]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-23-1249","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1158\/2159-8290.27168633","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27168627","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.27168630","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.22.563273","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/2159-8290.c.7479936","asserted-by":"object"}]},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,28]]}}}