{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:03:11Z","timestamp":1791270191038,"version":"4.1.0"},"reference-count":15,"publisher":"American Association for Cancer Research (AACR)","issue":"4","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,4]]},"abstract":"<jats:sec>\n                    <jats:title>Summary:<\/jats:title>\n                    <jats:p>We explore the phenomenon of somatic mutations, including those in cancer driver genes, that are present in healthy, normal-appearing tissues and their potential implications for cancer development. We also examine the landscape of these somatic mutations, discuss the role of clonal cell competition and external factors like inflammation in enhancing the fitness of mutant clones, and conclude by considering how understanding these mutations will aid in prevention and\/or interception of cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-23-1508","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T03:07:11Z","timestamp":1712200031000},"page":"605-609","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Somatic Mutations in Normal Tissues: Calm before the Storm"],"prefix":"10.1158","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3595-7027","authenticated-orcid":false,"given":"Zahraa","family":"Rahal","sequence":"first","affiliation":[{"name":"1Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-7497","authenticated-orcid":false,"given":"Paul","family":"Scheet","sequence":"additional","affiliation":[{"name":"2Department of Epidemiology, the University of Texas MD Anderson Cancer Center, Houston, Texas."},{"name":"3The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences (GSBS), Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-9115","authenticated-orcid":false,"given":"Humam","family":"Kadara","sequence":"additional","affiliation":[{"name":"1Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas."},{"name":"3The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences (GSBS), Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"2026050712252366700_bib1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1158\/2159-8290.CD-21-1110","article-title":"Cancer-causative mutations occurring in early embryogenesis","volume":"12","author":"Pareja","year":"2022","journal-title":"Cancer Discov"},{"key":"2026050712252366700_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13073-019-0648-4","article-title":"Somatic mutation and clonal expansions in human tissues","volume":"11","author":"Martincorena","year":"2019","journal-title":"Genome Med"},{"key":"2026050712252366700_bib3","doi-asserted-by":"crossref","first-page":"108251","DOI":"10.1016\/j.pharmthera.2022.108251","article-title":"Game of clones: Battles in the field of carcinogenesis","volume":"237","author":"Rahal","year":"2022","journal-title":"Pharmacol Ther"},{"key":"2026050712252366700_bib4","doi-asserted-by":"crossref","first-page":"eaaw0726","DOI":"10.1126\/science.aaw0726","article-title":"RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues","volume":"364","author":"Yizhak","year":"2019","journal-title":"Science"},{"key":"2026050712252366700_bib5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.aaa6806","article-title":"Tumor evolution. 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