{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:35:47Z","timestamp":1793360147798,"version":"4.5.0"},"reference-count":10,"publisher":"American Association for Cancer Research (AACR)","issue":"5","funder":[{"name":"NCI, DOD, ACS","award":["R01CA269660"],"award-info":[{"award-number":["R01CA269660"]}]},{"name":"NCI, DOD, ACS","award":["R01AR079545"],"award-info":[{"award-number":["R01AR079545"]}]},{"name":"NCI, DOD, ACS","award":["U54CA272686"],"award-info":[{"award-number":["U54CA272686"]}]},{"name":"NCI, DOD, ACS","award":["P30CA06927"],"award-info":[{"award-number":["P30CA06927"]}]},{"name":"NCI, DOD, ACS","award":["S10ODO23666"],"award-info":[{"award-number":["S10ODO23666"]}]},{"name":"NCI, DOD, ACS","award":["HT9425-23-1-0584"],"award-info":[{"award-number":["HT9425-23-1-0584"]}]},{"name":"NCI, DOD, ACS","award":["RP-23-1070169-01-WRP"],"award-info":[{"award-number":["RP-23-1070169-01-WRP"]}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:sec>\n                    <jats:title>Summary:<\/jats:title>\n                    <jats:p>O\u00f1ate and colleagues demonstrate that KITL expression in pancreatic stellate cells is crucial for maintaining the inherent tumor-suppressive function of the pancreatic microenvironment, and its loss enables pancreatic cancer development. This pivotal discovery not only reinforces the century-old hypothesis of natural microenvironmental tumor suppression but also highlights a promising therapeutic avenue whereby restoring KITL expression could reestablish the tumor-suppressive functions of pancreas-resident fibroblastic cells.<\/jats:p>\n                    <jats:p>See related article by O\u00f1ate et al., p. 913<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-25-0212","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T21:01:06Z","timestamp":1746046866000},"page":"872-874","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor 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