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In this study, we demonstrate that ctDNA is detectable 3 years or more before cancer diagnosis and provide estimates for the sensitivity required to achieve such very early detection.<\/jats:p>\n                    <jats:p>See related commentary by Crisafulli et al., p. 1774<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-25-0375","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T11:22:12Z","timestamp":1747912932000},"page":"1794-1802","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA"],"prefix":"10.1158","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2932-6042","authenticated-orcid":false,"given":"Yuxuan","family":"Wang","sequence":"first","affiliation":[{"name":"1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 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