{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:09:10Z","timestamp":1749010150064,"version":"3.41.0"},"reference-count":10,"publisher":"American Association for Cancer Research (AACR)","issue":"6","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>Summary:<\/jats:title>\n               <jats:p>A lack of understanding of how ovarian cancer originates in fallopian tube cells has hindered early detection and prevention, often resulting in diagnosis at advanced stages when treatment options are limited. In this issue of Cancer Discovery, two studies uncover critical microenvironmental changes that drive tumor initiation and progression, offering potential targets for earlier intervention.<\/jats:p>\n               <jats:p>See related article by Kader et al., p. 1180<\/jats:p>\n               <jats:p>See related article by Garcia et al., p. 1203<\/jats:p>","DOI":"10.1158\/2159-8290.cd-25-0429","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:08:53Z","timestamp":1748934533000},"page":"1093-1095","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Before They Were Malignant"],"prefix":"10.1158","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8064-9381","authenticated-orcid":false,"given":"Maria Sol","family":"Recouvreux","sequence":"first","affiliation":[{"name":"1Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-8721","authenticated-orcid":false,"given":"Sandra","family":"Orsulic","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California."},{"name":"2Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California."},{"name":"3Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California."},{"name":"4Department of Veterans Affairs, Greater Los Angeles Healthcare System, Los Angeles, 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