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Using genetically engineered mouse models and human tumor samples, we demonstrate that LKB1 loss leads to high expression of the cytokine leukemia-inhibitory factor (LIF), which through a cancer cell\u2013autonomous autocrine loop, orchestrates the infiltration of immunosuppressive SiglecFHi neutrophils and Arg1+ interstitial macrophages. Genetic deletion of Lifr, the receptor for LIF, on Lkb1-mutant lung tumors revealed that autocrine LIF signaling induces tumor plasticity and the emergence of a Sox17+ dedifferentiated inflammatory cell state. Antibody-mediated LIF neutralization selectively eliminates the Sox17+ tumor cell state, reduces immunosuppressive myeloid cells, and enhances antitumor T-cell responses. Our study uncovers a novel LKB1\u2013LIF axis driving immune evasion and identifies LIF as a potential therapeutic target in LKB1-mutant lung cancer. This work highlights the interplay between tumor genetics, cellular plasticity, and immune regulation in lung cancer progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>LKB1-mutant lung cancers express LIF, which induces an immunosuppressive Sox17+ tumor state. Anti-LIF therapy eliminates this state and restores antitumor immunity, revealing a novel vulnerability in this aggressive cancer subtype lacking effective targeted therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-25-0470","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T20:02:02Z","timestamp":1776715322000},"page":"1436-1455","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in\n                    <i>LKB1<\/i>\n                    -Mutant Lung Cancer"],"prefix":"10.1158","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-3463","authenticated-orcid":false,"given":"Ray","family":"Pillai","sequence":"first","affiliation":[{"name":"1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of 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development: raise standards for preclinical cancer research","volume":"483","author":"Begley","year":"2012","journal-title":"Nature"},{"key":"2026070103122741800_bib19","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026070103122741800_bib20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","author":"Cancer Genome Atlas Research Network","year":"2014","journal-title":"Nature"},{"key":"2026070103122741800_bib21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat Rev 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Rep"},{"key":"2026070103122741800_bib64","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026070103122741800_bib65","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s41556-021-00728-4","article-title":"LKB1 inactivation modulates chromatin accessibility to drive metastatic progression","volume":"23","author":"Pierce","year":"2021","journal-title":"Nat Cell Biol"},{"key":"2026070103122741800_bib66","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.molcel.2023.04.017","article-title":"LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation","volume":"83","author":"Compton","year":"2023","journal-title":"Mol 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