{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:20:55Z","timestamp":1789676455944,"version":"4.0.1"},"reference-count":9,"publisher":"American Association for Cancer Research (AACR)","issue":"9","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:title>Summary:<\/jats:title>\n               <jats:p>Kahn and colleagues reveal that lymph nodes (LN) provide an intrinsically immunosuppressive niche that prevents effector function of activated CD8+ T cells in LNs and allows immunogenic tumor cells to survive and drive cancer progression, independent of tumor-derived preconditioning. By locally suppressing IL2 availability, regulatory T cells in LNs impair CD8+ T-cell cytotoxicity\u2014a mechanism with important implications for immune checkpoint therapy and LN-targeted immunomodulation.<\/jats:p>\n               <jats:p>See related article by Kahn et al., p. 1949<\/jats:p>","DOI":"10.1158\/2159-8290.cd-25-1043","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:07:13Z","timestamp":1756969633000},"page":"1780-1782","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immune Privilege Within: Regulatory T Cells Tip the Balance in Favor of Lymph Node Metastasis"],"prefix":"10.1158","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-6255","authenticated-orcid":false,"given":"Lutz","family":"Menzel","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Edwin L. 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