{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:57:05Z","timestamp":1790841425998,"version":"4.1.0"},"reference-count":55,"publisher":"American Association for Cancer Research (AACR)","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":73,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1366 - project number: 394046768"],"award-info":[{"award-number":["CRC1366 - project number: 394046768"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC-TR 209 - project number: 314905040"],"award-info":[{"award-number":["CRC-TR 209 - project number: 314905040"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["project number: 510602219"],"award-info":[{"award-number":["project number: 510602219"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC AdG Angiomture - project number: 787181"],"award-info":[{"award-number":["ERC AdG Angiomture - project number: 787181"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["Excellenc program for established scientists - project number: 70114532"],"award-info":[{"award-number":["Excellenc program for established scientists - project number: 70114532"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC StG \u201cVascular-Rhythms\u201d - project number: 101220624"],"award-info":[{"award-number":["ERC StG \u201cVascular-Rhythms\u201d - project number: 101220624"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","award":["Postdoctoral Fellowship"],"award-info":[{"award-number":["Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003542","name":"Ministerium f\u00fcr Wissenschaft, Forschung und Kunst Baden-W\u00fcrttemberg","doi-asserted-by":"publisher","award":["Innovation Campus"],"award-info":[{"award-number":["Innovation Campus"]}],"id":[{"id":"10.13039\/501100003542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Combination therapies involving vascular targeting drugs have shown promise in overcoming resistance to immunotherapy. However, the prerequisite for vascular modulation to evoke an effective antitumor T-cell response remains elusive. Tracing the transcriptional response of liver metastasis\u2013associated peritumoral and tumor endothelial cells (TEC) to T-cell intervention, we discovered an immunomodulatory TEC subpopulation that highly expressed lipoprotein lipase (LPL). LPL+ TECs facilitated intratumoral homing of activated antitumor CD8+ T cells driving liver metastatic regression. Mechanistically, LPL enhanced MHC-I\u2013dependent cross-presentation of tumor antigens on TECs for T-cell trafficking. Consequently, LPL+ TECs were recognized and targeted by T cells, further aiding antitumor response. Corresponding analyses of human liver metastasis samples identified a significant correlation between the presence of intratumoral LPL+ blood vessels and the accumulation of T cells. Altogether, the study identifies a decisive role of TECs in orchestrating an effective T-cell response by overcoming tumor\u2019s intrinsic insufficient antigen presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>The study identifies LPL+ TECs as orchestrators of activated CD8+ T-cell homing into immunologically cold tumors with low baseline MHC-I expression. Enhancing tumor antigen exposure by MHC-I cross-presentation in TECs presents a promising approach to compensate the intrinsic inability of tumor cells and boost antitumor immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/2159-8290.cd-25-1411","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:01:59Z","timestamp":1784556119000},"page":"2151-2171","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis"],"prefix":"10.1158","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3706-6849","authenticated-orcid":false,"given":"Xiaowen","family":"Zhang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 1 Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, , Mannheim, Germany."},{"id":[{"id":"https:\/\/ror.org\/04cdgtt98","id-type":"ROR","asserted-by":"publisher"}],"name":"German Cancer Research Center (DKFZ) 2 Division of Vascular Oncology and Metastasis, , Heidelberg, Germany."},{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 3 Faculty of Biosciences, , Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-6703","authenticated-orcid":false,"given":"Miki","family":"Kamiyama","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 4 Laboratory of AngioRhythms, European Center for Angioscience (ECAS), Medical Faculty Mannheim, , Mannheim, Germany."},{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 5 Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), , Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3854-5288","authenticated-orcid":false,"given":"Margaret","family":"Tulessin","sequence":"additional","affiliation":[{"name":"6Institute of Pathology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4198-7654","authenticated-orcid":false,"given":"Lorna","family":"Rinck","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 4 Laboratory of AngioRhythms, European Center for Angioscience (ECAS), Medical Faculty Mannheim, , Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-4030","authenticated-orcid":false,"given":"Jan-Philipp","family":"Mallm","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cdgtt98","id-type":"ROR","asserted-by":"publisher"}],"name":"German Cancer Research Center (DKFZ) 7 Single-Cell Open Lab (scOpenLab), , Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1946-3174","authenticated-orcid":false,"given":"Michael","family":"Kilian","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 8 Department of Neurology, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, , Mannheim, Germany."},{"id":[{"id":"https:\/\/ror.org\/04cdgtt98","id-type":"ROR","asserted-by":"publisher"}],"name":"German Cancer Research Center (DKFZ) 9 Clinical Cooperation Unit of Neuroimmunology and Brain Tumor Immunology, , Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6900-2504","authenticated-orcid":false,"given":"Dennis A.","family":"Agardy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 8 Department of Neurology, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, , Mannheim, Germany."},{"id":[{"id":"https:\/\/ror.org\/04cdgtt98","id-type":"ROR","asserted-by":"publisher"}],"name":"German Cancer Research Center (DKFZ) 9 Clinical Cooperation Unit of Neuroimmunology and Brain Tumor Immunology, , Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-2274","authenticated-orcid":false,"given":"Mathias","family":"Heikenw\u00e4lder","sequence":"additional","affiliation":[{"name":"10Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany."},{"name":"11M3 Research Institute, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4746-887X","authenticated-orcid":false,"given":"Michael","family":"Platten","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 8 Department of Neurology, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, , Mannheim, Germany."},{"id":[{"id":"https:\/\/ror.org\/04cdgtt98","id-type":"ROR","asserted-by":"publisher"}],"name":"German Cancer Research Center (DKFZ) 9 Clinical Cooperation Unit of Neuroimmunology and Brain Tumor Immunology, , Heidelberg, Germany."},{"name":"12DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany."},{"name":"13German Cancer Consortium (DKTK), Heidelberg, Germany."},{"name":"14Helmholtz-Institute for Translational Oncology (HI-TRON), Mainz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-7254","authenticated-orcid":false,"given":"Carolin","family":"Mogler","sequence":"additional","affiliation":[{"name":"6Institute of Pathology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-9585","authenticated-orcid":false,"given":"Mahak","family":"Singhal","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 4 Laboratory of AngioRhythms, European Center for Angioscience (ECAS), Medical Faculty Mannheim, , Mannheim, Germany."},{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 5 Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), , Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-4242","authenticated-orcid":false,"given":"Hellmut G.","family":"Augustin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/038t36y30","id-type":"ROR","asserted-by":"publisher"}],"name":"Heidelberg University 1 Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, , Mannheim, Germany."},{"id":[{"id":"https:\/\/ror.org\/04cdgtt98","id-type":"ROR","asserted-by":"publisher"}],"name":"German Cancer Research Center (DKFZ) 2 Division of Vascular Oncology and Metastasis, , Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026100103112173100_bib1","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1016\/j.cell.2023.03.006","article-title":"Immune checkpoint therapy-current perspectives and future directions","volume":"186","author":"Sharma","year":"2023","journal-title":"Cell"},{"key":"2026100103112173100_bib2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41577-019-0218-4","article-title":"Tumour-intrinsic resistance to immune checkpoint blockade","volume":"20","author":"Kalbasi","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"2026100103112173100_bib3","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41568-024-00736-0","article-title":"Targeting the tumour vasculature: from vessel destruction to promotion","volume":"24","author":"Guelfi","year":"2024","journal-title":"Nat Rev Cancer"},{"key":"2026100103112173100_bib4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41568-019-0125-9","article-title":"Host tissue determinants of tumour immunity","volume":"19","author":"Salmon","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"2026100103112173100_bib5","doi-asserted-by":"publisher","first-page":"eaak9679","DOI":"10.1126\/scitranslmed.aak9679","article-title":"Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation","volume":"9","author":"Allen","year":"2017","journal-title":"Sci Transl Med"},{"key":"2026100103112173100_bib6","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ccell.2022.01.002","article-title":"Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy","volume":"40","author":"Asrir","year":"2022","journal-title":"Cancer Cell"},{"key":"2026100103112173100_bib7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ccell.2022.12.006","article-title":"Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop","volume":"41","author":"Hua","year":"2023","journal-title":"Cancer Cell"},{"key":"2026100103112173100_bib8","doi-asserted-by":"publisher","first-page":"4470","DOI":"10.1073\/pnas.1525349113","article-title":"Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages","volume":"113","author":"Peterson","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026100103112173100_bib9","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.ccell.2023.04.010","article-title":"Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma","volume":"41","author":"Ramachandran","year":"2023","journal-title":"Cancer Cell"},{"key":"2026100103112173100_bib10","doi-asserted-by":"publisher","first-page":"eaak9670","DOI":"10.1126\/scitranslmed.aak9670","article-title":"Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade","volume":"9","author":"Schmittnaegel","year":"2017","journal-title":"Sci Transl Med"},{"key":"2026100103112173100_bib11","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","article-title":"Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma","volume":"382","author":"Finn","year":"2020","journal-title":"N Engl J Med"},{"key":"2026100103112173100_bib12","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.jhep.2021.11.030","article-title":"Updated efficacy and safety data from IMbrave150: atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma","volume":"76","author":"Cheng","year":"2022","journal-title":"J Hepatol"},{"key":"2026100103112173100_bib13","doi-asserted-by":"publisher","first-page":"200ra116","DOI":"10.1126\/scitranslmed.3006504","article-title":"Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells","volume":"5","author":"Spranger","year":"2013","journal-title":"Sci Transl Med"},{"key":"2026100103112173100_bib14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.molcel.2019.09.030","article-title":"Mechanisms controlling PD-L1 expression in cancer","volume":"76","author":"Cha","year":"2019","journal-title":"Mol Cell"},{"key":"2026100103112173100_bib15","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.medj.2022.05.001","article-title":"Understanding CAR T cell-tumor interactions: paving the way for successful clinical outcomes","volume":"3","author":"Korell","year":"2022","journal-title":"Med"},{"key":"2026100103112173100_bib16","doi-asserted-by":"publisher","first-page":"17247","DOI":"10.1074\/jbc.271.29.17247","article-title":"Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene","volume":"271","author":"Chon","year":"1996","journal-title":"J Biol Chem"},{"key":"2026100103112173100_bib17","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1128\/IAI.70.2.859-868.2002","article-title":"Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1","volume":"70","author":"Silva","year":"2002","journal-title":"Infect Immun"},{"key":"2026100103112173100_bib18","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/nbt.4231","article-title":"Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells","volume":"36","author":"Halpern","year":"2018","journal-title":"Nat Biotechnol"},{"key":"2026100103112173100_bib19","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.cell.2020.01.015","article-title":"Single-cell transcriptome atlas of murine endothelial cells","volume":"180","author":"Kalucka","year":"2020","journal-title":"Cell"},{"key":"2026100103112173100_bib20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2020.03.002","article-title":"An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates","volume":"37","author":"Goveia","year":"2020","journal-title":"Cancer Cell"},{"key":"2026100103112173100_bib21","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1158\/2159-8290.CD-20-0122","article-title":"Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis","volume":"11","author":"Gengenbacher","year":"2021","journal-title":"Cancer Discov"},{"key":"2026100103112173100_bib22","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2021.01.002","article-title":"Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition","volume":"184","author":"Litchfield","year":"2021","journal-title":"Cell"},{"key":"2026100103112173100_bib23","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00109-002-0384-9","article-title":"Lipoprotein lipase: structure, function, regulation, and role in disease","volume":"80","author":"Mead","year":"2002","journal-title":"J Mol Med (Berl)"},{"key":"2026100103112173100_bib24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.cmet.2019.05.023","article-title":"GPIHBP1 and lipoprotein lipase, partners in plasma triglyceride metabolism","volume":"30","author":"Young","year":"2019","journal-title":"Cell Metab"},{"key":"2026100103112173100_bib25","doi-asserted-by":"publisher","first-page":"102322","DOI":"10.1016\/j.jbc.2022.102322","article-title":"Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice","volume":"298","author":"Takahashi","year":"2022","journal-title":"J Biol Chem"},{"key":"2026100103112173100_bib26","doi-asserted-by":"publisher","first-page":"eadi6682","DOI":"10.1126\/scitranslmed.adi6682","article-title":"ABCG1 orchestrates adipose tissue macrophage plasticity and insulin resistance in obesity by rewiring saturated fatty acid pools","volume":"16","author":"Dahik","year":"2024","journal-title":"Sci Transl Med"},{"key":"2026100103112173100_bib27","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41586-023-06733-x","article-title":"Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer","volume":"624","author":"Zhou","year":"2023","journal-title":"Nature"},{"key":"2026100103112173100_bib28","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1158\/1541-7786.MCR-19-0897","article-title":"Tumor endothelial cell-mediated antigen-specific T-cell suppression via the PD-1\/PD-L1 pathway","volume":"18","author":"Taguchi","year":"2020","journal-title":"Mol Cancer Res"},{"key":"2026100103112173100_bib29","doi-asserted-by":"publisher","first-page":"eabl5162","DOI":"10.1126\/sciadv.abl5162","article-title":"IFN-gamma-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis","volume":"8","author":"Garnier","year":"2022","journal-title":"Sci Adv"},{"key":"2026100103112173100_bib30","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1038\/s41467-023-38703-2","article-title":"Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown","volume":"14","author":"Aydin","year":"2023","journal-title":"Nat Commun"},{"key":"2026100103112173100_bib31","doi-asserted-by":"publisher","first-page":"4241","DOI":"10.1038\/s41467-019-12017-8","article-title":"Lung endothelial cell antigen cross-presentation to CD8+ T cells drives malaria-associated lung injury","volume":"10","author":"Claser","year":"2019","journal-title":"Nat Commun"},{"key":"2026100103112173100_bib32","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41577-022-00694-4","article-title":"Immunomodulation by endothelial cells - partnering up with the immune system","volume":"22","author":"Amersfoort","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"2026100103112173100_bib33","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/cmi.2016.5","article-title":"Immunological functions of liver sinusoidal endothelial cells","volume":"13","author":"Knolle","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"2026100103112173100_bib34","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1084\/jem.20142047","article-title":"Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells","volume":"212","author":"Herz","year":"2015","journal-title":"J Exp Med"},{"key":"2026100103112173100_bib35","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3389\/fimmu.2015.00603","article-title":"T lymphocyte-endothelial Interactions: emerging understanding of trafficking and antigen-specific immunity","volume":"6","author":"Carman","year":"2015","journal-title":"Front Immunol"},{"key":"2026100103112173100_bib36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.immuni.2019.12.011","article-title":"Top 10 challenges in cancer immunotherapy","volume":"52","author":"Hegde","year":"2020","journal-title":"Immunity"},{"key":"2026100103112173100_bib37","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S2213-2600(19)30084-0","article-title":"Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial","volume":"7","author":"Reck","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2026100103112173100_bib38","doi-asserted-by":"publisher","first-page":"844866","DOI":"10.3389\/fimmu.2022.844866","article-title":"Mechanisms of MHC-I downregulation and role in immunotherapy response","volume":"13","author":"Taylor","year":"2022","journal-title":"Front Immunol"},{"key":"2026100103112173100_bib39","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00251-008-0303-5","article-title":"Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy","volume":"60","author":"Carretero","year":"2008","journal-title":"Immunogenetics"},{"key":"2026100103112173100_bib40","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1038\/s41591-022-01868-2","article-title":"Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma","volume":"28","author":"Zhu","year":"2022","journal-title":"Nat Med"},{"key":"2026100103112173100_bib41","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.immuni.2025.02.022","article-title":"Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors","volume":"58","author":"Bejarano","year":"2025","journal-title":"Immunity"},{"key":"2026100103112173100_bib42","doi-asserted-by":"publisher","first-page":"5511","DOI":"10.1038\/s41467-022-33052-y","article-title":"Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast","volume":"13","author":"Geldhof","year":"2022","journal-title":"Nat Commun"},{"key":"2026100103112173100_bib43","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1016\/j.ccell.2025.10.008","article-title":"Remodeling of T and endothelial cells during total neoadjuvant therapy in rectal cancer","volume":"43","author":"Gao","year":"2025","journal-title":"Cancer Cell"},{"key":"2026100103112173100_bib44","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1158\/2326-6066.CIR-20-0784","article-title":"MHC Class II antigen presentation by lymphatic endothelial cells in tumors promotes intratumoral regulatory T cell-suppressive functions","volume":"9","author":"Gkountidi","year":"2021","journal-title":"Cancer Immunol Res"},{"key":"2026100103112173100_bib45","doi-asserted-by":"publisher","first-page":"31076","DOI":"10.1074\/jbc.M412189200","article-title":"Differential effects of lipoprotein lipase on tumor necrosis factor-alpha and interferon-gamma-mediated gene expression in human endothelial cells","volume":"280","author":"Kota","year":"2005","journal-title":"J Biol Chem"},{"key":"2026100103112173100_bib46","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1093\/brain\/awad319","article-title":"Discrete class I molecules on brain endothelium differentially regulate neuropathology in experimental cerebral malaria","volume":"147","author":"Fain","year":"2024","journal-title":"Brain"},{"key":"2026100103112173100_bib47","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N Engl J Med"},{"key":"2026100103112173100_bib48","doi-asserted-by":"publisher","first-page":"4833","DOI":"10.1016\/j.cell.2024.07.012","article-title":"A systems view of the vascular endothelium in health and disease","volume":"187","author":"Augustin","year":"2024","journal-title":"Cell"},{"key":"2026100103112173100_bib49","doi-asserted-by":"publisher","first-page":"51677","DOI":"10.3791\/51677","article-title":"A preclinical murine model of hepatic metastases","volume":"91","author":"Soares","year":"2014","journal-title":"J Vis Exp"},{"key":"2026100103112173100_bib50","doi-asserted-by":"publisher","first-page":"eabe6805","DOI":"10.1126\/scitranslmed.abe6805","article-title":"Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis","volume":"13","author":"Singhal","year":"2021","journal-title":"Sci Transl Med"},{"key":"2026100103112173100_bib51","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s42003-025-07458-5","article-title":"A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells","volume":"8","author":"Babin-Ebell Gon\u00e7alves","year":"2025","journal-title":"Commun Biol"},{"key":"2026100103112173100_bib52","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"2026100103112173100_bib53","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"2026100103112173100_bib54","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat Biotechnol"},{"key":"2026100103112173100_bib55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"}],"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/doi\/10.1158\/2159-8290.CD-25-1411\/3813839\/cd-25-1411.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/16\/10\/2151\/3832865\/cd-25-1411.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/16\/10\/2151\/3832865\/cd-25-1411.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:11:34Z","timestamp":1790838694000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/16\/10\/2151\/788543\/LPL-Positive-Endothelial-Cells-Control-T-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":55,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,7,20]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-25-1411","relation":{"has-preprint":[{"id-type":"doi","id":"10.1158\/2159-8290.c.8748156","asserted-by":"object"}],"is-supplemented-by":[{"id-type":"doi","id":"10.1158\/2159-8290.34040886","asserted-by":"object"}]},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]}}}