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By stimulating aryl hydrocarbon receptors in CD4+ T cells, 2,3,7,8-tetrachlorodibenzo-p-dioxin skews the pancreatic immune landscape toward tolerance by promoting the expansion of IL22-secreting Th22 cells and regulatory T cells while simultaneously depleting tumor-targeting CD8+ T cells, thereby accelerating pancreatic dysplasia and tumor progression.<\/jats:p>\n                  <jats:p>See related article by Griffith et al., p. 114<\/jats:p>","DOI":"10.1158\/2159-8290.cd-25-1593","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:10:16Z","timestamp":1768205416000},"page":"13-15","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cigarette Smoke Skews T Cells to Promote Pancreatic 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