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Here, we report that a single post-lactation dose of cabergoline, a dopaminergic agonist that blocks prolactin secretion, delays the onset and reduces the incidence of postpartum mammary cancer in K14-Cre; Brca1F\/F, Trp53F\/F mice. In these mice, cabergoline treatment remodels the mammary gland by potentiating involution, reducing ductal area and proliferation, and reversing T cell exhaustion, potentially through modulation of ion channel expression. Notably, independent retrospective studies in two large cohorts of European women showed that cabergoline treatment was associated with a lower incidence of postpartum breast cancer, with a meta-analysis indicating an approximate 69% reduction in risk. Our work underscores the importance of targeting postlactational involution as a strategy for the prevention of postpartum breast cancer and positions cabergoline as a novel, low-risk chemoprevention strategy.<\/jats:p>","DOI":"10.1158\/2159-8290.cd-26-0187","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:01:41Z","timestamp":1792072901000},"update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cabergoline Suppresses Postpartum Breast Cancer by Enhancing Mammary Gland Involution in Brca1-Mutant Mice and Is Associated with Reduced Risk in Younger Women"],"prefix":"10.1158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7731-7020","authenticated-orcid":false,"given":"Natalia","family":"Garc\u00eda-Sancha","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer (CIC-IBMCC). 2 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