{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:36:34Z","timestamp":1785418594971,"version":"3.56.0"},"reference-count":16,"publisher":"American Association for Cancer Research (AACR)","issue":"4","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Summary:<\/jats:title>\n                  <jats:p>Cancer Grand Challenges is an international research initiative, galvanizing the global research community to take on cancer\u2019s toughest challenges through interdisciplinary team science. In this article, we introduce our five new teams, each awarded up to $25 million and their creative approaches to tackle five of our latest challenges.<\/jats:p>","DOI":"10.1158\/2159-8290.cd-26-0215","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T11:31:48Z","timestamp":1772623908000},"page":"633-636","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Five New Cancer Grand Challenges Teams Taking on the Biggest Questions in Cancer Research"],"prefix":"10.1158","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-5650","authenticated-orcid":false,"given":"Rebecca L.","family":"Eccles","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/054225q67","id-type":"ROR","asserted-by":"publisher"}],"name":"Cancer Research UK 1 Cancer Grand Challenges, , London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-6225","authenticated-orcid":false,"given":"Gabriela","family":"Carreno","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/054225q67","id-type":"ROR","asserted-by":"publisher"}],"name":"Cancer Research UK 1 Cancer Grand Challenges, , London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-122X","authenticated-orcid":false,"given":"Blake E.","family":"Sanders","sequence":"additional","affiliation":[{"name":"2Cancer Grand Challenges, American Friends of Cancer Research, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-207X","authenticated-orcid":false,"given":"Lorenzo","family":"de la Rica","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/054225q67","id-type":"ROR","asserted-by":"publisher"}],"name":"Cancer Research UK 1 Cancer Grand Challenges, , London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-3018","authenticated-orcid":false,"given":"Dinah S.","family":"Singer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}],"name":"National Cancer Institute 3 , Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7213-3564","authenticated-orcid":false,"given":"David","family":"Scott","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/054225q67","id-type":"ROR","asserted-by":"publisher"}],"name":"Cancer Research UK 1 Cancer Grand Challenges, , London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"2026040103153918400_bib1","first-page":"e70043","article-title":"Cancer statistics, 2026","volume":"76","author":"Siegel","year":"2026","journal-title":"CA Cancer J Clin"},{"key":"2026040103153918400_bib2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1158\/2159-8290.CD-25-0282","article-title":"Tackling cancer through global team science","volume":"15","author":"Eccles","year":"2025","journal-title":"Cancer Discov"},{"key":"2026040103153918400_bib3","doi-asserted-by":"crossref","first-page":"eabd4585","DOI":"10.1126\/science.abd4585","article-title":"Autoantibodies against type I IFNs in patients with life-threatening COVID-19","volume":"370","author":"Bastard","year":"2020","journal-title":"Science"},{"key":"2026040103153918400_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-025-09188-4","article-title":"Humoral determinants of checkpoint immunotherapy","volume":"644","author":"Dai","year":"2025","journal-title":"Nature"},{"key":"2026040103153918400_bib5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1158\/2159-8290.CD-24-1687","article-title":"Implementing mutational epidemiology on a global scale: lessons from Mutographs","volume":"15","author":"Stratton","year":"2025","journal-title":"Cancer Discov"},{"key":"2026040103153918400_bib6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41586-025-09025-8","article-title":"Geographic and age variations in mutational processes in colorectal cancer","volume":"643","author":"D\u00edaz-Gay","year":"2025","journal-title":"Nature"},{"key":"2026040103153918400_bib7","doi-asserted-by":"crossref","first-page":"eady3571","DOI":"10.1126\/science.ady3571","article-title":"The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin","volume":"390","author":"Carlson","year":"2025","journal-title":"Science"},{"key":"2026040103153918400_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling","volume":"324","author":"Ingolia","year":"2009","journal-title":"Science"},{"key":"2026040103153918400_bib9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41586-022-04499-2","article-title":"Tryptophan depletion results in tryptophan-to-phenylalanine substitutants","volume":"603","author":"Pataskar","year":"2022","journal-title":"Nature"},{"key":"2026040103153918400_bib10","doi-asserted-by":"crossref","first-page":"13964","DOI":"10.1093\/nar\/gkae1110","article-title":"Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer","volume":"52","author":"Kochavi","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026040103153918400_bib11","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.neuron.2025.04.009","article-title":"The nervous system and cancer: a grand challenge and a call to collaborate","volume":"113","author":"Carreno","year":"2025","journal-title":"Neuron"},{"key":"2026040103153918400_bib12","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41586-024-08575-7","article-title":"Intrinsic electrical activity drives small-cell lung cancer progression","volume":"639","author":"Peinado","year":"2025","journal-title":"Nature"},{"key":"2026040103153918400_bib13","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.ccell.2025.09.003","article-title":"Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses","volume":"43","author":"Ren","year":"2025","journal-title":"Cancer Cell"},{"key":"2026040103153918400_bib14","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.trecan.2025.04.009","article-title":"Prospects for understanding and exploiting the consequences of hyperactivation lethality","volume":"11","author":"Shaw","year":"2025","journal-title":"Trends Cancer"},{"key":"2026040103153918400_bib15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-023-05972-2","article-title":"A small-molecule PI3K\u03b1 activator for cardioprotection and neuroregeneration","volume":"618","author":"Gong","year":"2023","journal-title":"Nature"},{"key":"2026040103153918400_bib16","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41586-024-08150-0","article-title":"Progressive plasticity during colorectal cancer metastasis","volume":"637","author":"Moorman","year":"2025","journal-title":"Nature"}],"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/doi\/10.1158\/2159-8290.CD-26-0215\/3744659\/cd-26-0215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/16\/4\/633\/3749537\/cd-26-0215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/16\/4\/633\/3749537\/cd-26-0215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:15:44Z","timestamp":1775027744000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/16\/4\/633\/775552\/The-Five-New-Cancer-Grand-Challenges-Teams-Taking"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,3,4]]},"published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-26-0215","relation":{},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]}}}