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By integrating volumetric reconstruction with multimodal spatial profiling, Storrs and colleagues revealed the precancer-to-cancer transition as a continuous three-dimensional process and identified shared molecular programs associated with invasion.<\/jats:p>\n                  <jats:p>See related article by Storrs et al., p. 1819<\/jats:p>","DOI":"10.1158\/2159-8290.cd-26-1266","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:08:38Z","timestamp":1788246518000},"page":"1720-1723","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant Transition in Three Dimensions"],"prefix":"10.1158","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7275-0869","authenticated-orcid":false,"given":"Zehua","family":"Jing","sequence":"first","affiliation":[{"name":"1Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2422-9494","authenticated-orcid":false,"given":"Mingyao","family":"Li","sequence":"additional","affiliation":[{"name":"1Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania."},{"name":"2Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026090103074059700_bib1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","author":"Cancer Genome Atlas Network","year":"2012","journal-title":"Nature"},{"key":"2026090103074059700_bib2","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.cell.2015.10.025","article-title":"The molecular taxonomy of primary prostate cancer","volume":"163","author":"Cancer Genome Atlas Research Network","year":"2015","journal-title":"Cell"},{"key":"2026090103074059700_bib3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrc2795","article-title":"Breast and prostate cancer: more similar than different","volume":"10","author":"Risbridger","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"2026090103074059700_bib4","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1158\/2159-8290","article-title":"Spatial mapping of the precancer-to-cancer transition in breast and prostate","volume":"16","author":"Storrs","year":"2026","journal-title":"Cancer Discov"},{"key":"2026090103074059700_bib5","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1056\/NEJMclde1512213","article-title":"CLINICAL DECISIONS. 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