{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:58:10Z","timestamp":1790841490065,"version":"4.1.0"},"reference-count":11,"publisher":"American Association for Cancer Research (AACR)","issue":"10","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Summary:<\/jats:title>\n                  <jats:p>In this issue of Cancer Discovery, Chen and colleagues leverage single-cell RNA sequencing of neutrophils in the tumor microenvironment of colorectal cancer liver metastases to characterize neutrophil heterogeneity within the metastatic immune landscape. They show that the glucose-deprived metastatic microenvironment drives BHLHE40 upregulation in neutrophils, inducing a senescent tumor-associated neutrophil (TAN) population, TAN1, that actively promotes angiogenesis and excludes CD8+ T cells from the tumor, thereby supporting tumor growth and survival.<\/jats:p>\n                  <jats:p>See related article by Chen et al., p. 2130<\/jats:p>","DOI":"10.1158\/2159-8290.cd-26-1529","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:13:20Z","timestamp":1790838800000},"page":"1958-1960","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When Neutrophils Do Not Die: Senescence as a New Axis of Tumor 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