{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:02:30Z","timestamp":1763017350407},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"1","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The U.S. Food and Drug Administration (FDA) approved the targeted therapy ibrutinib for treating patients with mantle cell lymphoma who have received at least one prior therapy. The drug is the second designated by the FDA as a \u201cbreakthrough therapy\u201d to be granted approval by the agency.<\/jats:p>","DOI":"10.1158\/2159-8290.cd-nb2013-172","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T04:07:02Z","timestamp":1386907622000},"page":"OF1-OF1","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ibrutinib Approved for Mantle Cell Lymphoma"],"prefix":"10.1158","volume":"4","member":"1086","published-online":{"date-parts":[[2014,1,7]]},"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/4\/1\/OF1\/3809\/Ibrutinib-Approved-for-Mantle-Cell","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/4\/1\/OF1\/3809\/Ibrutinib-Approved-for-Mantle-Cell","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T23:14:38Z","timestamp":1654557278000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/4\/1\/OF1\/3809\/Ibrutinib-Approved-for-Mantle-Cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,7]]},"published-print":{"date-parts":[[2014,1,1]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-nb2013-172","relation":{},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}