{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T16:29:47Z","timestamp":1744820987091},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"10","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Two studies have illuminated some of the molecular underpinnings of T-cell exhaustion. The first pinpoints the subset of exhausted T cells that revive upon PD-1 blockade. The second describes key metabolic deficiencies\u2014restricted glucose uptake and mitochondrial dysfunction\u2014that drive T cells to exhaustion.<\/jats:p>","DOI":"10.1158\/2159-8290.cd-nb2016-104","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T01:59:14Z","timestamp":1472003954000},"page":"OF3-OF3","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Illuminating T-cell Exhaustion"],"prefix":"10.1158","volume":"6","member":"1086","published-online":{"date-parts":[[2016,10,2]]},"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/6\/10\/OF3\/5224\/Illuminating-T-cell-ExhaustionIlluminating-T-cell","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/6\/10\/OF3\/5224\/Illuminating-T-cell-ExhaustionIlluminating-T-cell","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:15:54Z","timestamp":1654560954000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/6\/10\/OF3\/5224\/Illuminating-T-cell-ExhaustionIlluminating-T-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,2]]},"published-print":{"date-parts":[[2016,10,1]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-nb2016-104","relation":{},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,1]]}}}