{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T22:41:44Z","timestamp":1654555304374},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"12","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An excess of exhausted T cells may explain why some patients with large B-cell lymphoma do not benefit from chimeric antigen receptor (CAR) T cells, a recent study concludes. The research also shows that patients with monocyte-like cells in their infusions are more likely to develop severe neurologic side effects. The study suggests measures to increase the effectiveness and safety of CAR T-cell products.<\/jats:p>","DOI":"10.1158\/2159-8290.cd-nb2020-096","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T17:56:25Z","timestamp":1603475785000},"page":"1780-1780","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CAR T-cell Characteristics Determine Efficacy"],"prefix":"10.1158","volume":"10","member":"1086","published-online":{"date-parts":[[2020,12,1]]},"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/10\/12\/1780\/1712668\/1780a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/10\/12\/1780\/1712668\/1780a.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T22:16:37Z","timestamp":1654553797000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/10\/12\/1780\/2412\/CAR-T-cell-Characteristics-Determine-EfficacyCAR-T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,1]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-nb2020-096","relation":{},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}