{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:34:43Z","timestamp":1790073283184,"version":"4.0.1"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"6","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>According to data from two ongoing phase I studies for patients with metastatic melanoma whose disease is refractory to PD-1 blockade, the addition of either CMP-001 or SD-101\u2014both investigational TLR9 agonists\u2014could help reverse this resistance.<\/jats:p>","DOI":"10.1158\/2159-8290.cd-nd2018-004","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T13:37:03Z","timestamp":1524058623000},"page":"670-670","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Warming \u201cCold\u201d Melanoma with TLR9 Agonists"],"prefix":"10.1158","volume":"8","member":"1086","published-online":{"date-parts":[[2018,5,31]]},"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/8\/6\/670\/2951951\/670.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article-pdf\/8\/6\/670\/2951951\/670.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T01:25:41Z","timestamp":1654565141000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/8\/6\/670\/10234\/Warming-Cold-Melanoma-with-TLR9-AgonistsWarming"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,5,31]]},"published-print":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-nd2018-004","relation":{},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,31]]}}}