{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T11:28:38Z","timestamp":1768217318892,"version":"3.49.0"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"1","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"abstract":"<jats:p>In the phase III GIMEMA ALL2820 trial, treatment with ponatinib and blinatumomab led to significantly better response rates and overall survival than a chemotherapy\u2013imatinib regimen for patients with Philadelphia chromosome\u2013positive acute lymphoblastic leukemia. The findings could change the standard of care for the disease.<\/jats:p>","DOI":"10.1158\/2159-8290.cd-nw2025-0110","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:57:30Z","timestamp":1765979850000},"page":"OF1-OF1","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phase III Data Support Chemo-Free Approach to ALL"],"prefix":"10.1158","volume":"16","member":"1086","published-online":{"date-parts":[[2025,12,9]]},"container-title":["Cancer Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/doi\/10.1158\/2159-8290.CD-NW2025-0110\/771082\/Phase-III-Data-Support-Chemo-Free-Approach-to","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/16\/1\/OF1\/771331\/Phase-III-Data-Support-Chemo-Free-Approach-to","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/16\/1\/OF1\/771331\/Phase-III-Data-Support-Chemo-Free-Approach-to","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:14:43Z","timestamp":1768205683000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/16\/1\/OF1\/771331\/Phase-III-Data-Support-Chemo-Free-Approach-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12,9]]},"published-print":{"date-parts":[[2026,1,12]]}},"URL":"https:\/\/doi.org\/10.1158\/2159-8290.cd-nw2025-0110","relation":{},"ISSN":["2159-8274","2159-8290"],"issn-type":[{"value":"2159-8274","type":"print"},{"value":"2159-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]}}}