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Retroviral transduction of MCF-7\/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-\u03b1 signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.<\/jats:p>","DOI":"10.1158\/0008-5472.can-04-0795","type":"journal-article","created":{"date-parts":[[2005,9,20]],"date-time":"2005-09-20T18:43:36Z","timestamp":1127241816000},"page":"8309-8317","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["P-Cadherin Is Up-Regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells"],"prefix":"10.1158","volume":"64","author":[{"given":"Joana","family":"Paredes","sequence":"first","affiliation":[{"name":"1Institute of Pathology and Molecular Immunology of Porto University and"}]},{"given":"Christophe","family":"Stove","sequence":"additional","affiliation":[{"name":"3Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine,"},{"name":"5Units of Molecular and Cellular Oncology and Molecular Cell Biology, Department of Molecular Biomedical Research, VIB-Ghent University, Ghent, Belgium"}]},{"given":"Veronique","family":"Stove","sequence":"additional","affiliation":[{"name":"4Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, and"}]},{"given":"Fernanda","family":"Milanezi","sequence":"additional","affiliation":[{"name":"1Institute of Pathology and Molecular Immunology of Porto University and"}]},{"given":"Veerle","family":"Van Marck","sequence":"additional","affiliation":[{"name":"3Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine,"}]},{"given":"Lara","family":"Derycke","sequence":"additional","affiliation":[{"name":"3Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine,"}]},{"given":"Marc","family":"Mareel","sequence":"additional","affiliation":[{"name":"3Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine,"}]},{"given":"Marc","family":"Bracke","sequence":"additional","affiliation":[{"name":"3Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine,"}]},{"given":"Fernando","family":"Schmitt","sequence":"additional","affiliation":[{"name":"1Institute of Pathology and Molecular Immunology of Porto University and"},{"name":"2Medical Faculty, Porto University, Porto, Portugal; and"}]}],"member":"1086","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"key":"2022061620152904200_B1","doi-asserted-by":"crossref","unstructured":"Conacci-Sorrell M, Zhurinsky J, Ben-Ze\u2019ev A The cadherin-catenin adhesion system in signaling and cancer. 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