{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:52:44Z","timestamp":1772164364509,"version":"3.50.1"},"reference-count":49,"publisher":"American Association for Cancer Research (AACR)","issue":"9","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Synthetic progesterone used in contraception drugs (progestins) can promote breast cancer growth, but the mechanisms involved are unknown. Moreover, it remains unclear whether cytoplasmic interactions between the progesterone receptor (PR) and estrogen receptor alpha (ER\u03b1) are required for PR activation. In this study, we used a murine progestin-dependent tumor to investigate the role of ER\u03b1 in progestin-induced tumor cell proliferation. We found that treatment with the progestin medroxyprogesterone acetate (MPA) induced the expression and activation of ER\u03b1, as well as rapid nuclear colocalization of activated ER\u03b1 with PR. Treatment with the pure antiestrogen fulvestrant to block ER\u03b1 disrupted the interaction of ER\u03b1 and PR in vitro and induced the regression of MPA-dependent tumor growth in vivo. ER\u03b1 blockade also prevented an MPA-induced increase in CYCLIN D1 (CCND1) and MYC expression. Chromatin immunoprecipitation studies showed that MPA triggered binding of ER\u03b1 and PR to the CCND1 and MYC promoters. Interestingly, blockade or RNAi-mediated silencing of ER\u03b1 inhibited ER\u03b1, but not PR binding to both regulatory sequences, indicating that an interaction between ER\u03b1 and PR at these sites is necessary for MPA-induced gene expression and cell proliferation. We confirmed that nuclear colocalization of both receptors also occurred in human breast cancer samples. Together, our findings argued that ER\u03b1\u2013PR association on target gene promoters is essential for progestin-induced cell proliferation. Cancer Res; 72(9); 2416\u201327. \u00a92012 AACR.<\/jats:p>","DOI":"10.1158\/0008-5472.can-11-3290","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T01:20:54Z","timestamp":1331083254000},"page":"2416-2427","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the\n                    <i>Cyclin D1\/MYC<\/i>\n                    Promoters"],"prefix":"10.1158","volume":"72","author":[{"given":"Sebasti\u00e1n","family":"Giulianelli","sequence":"first","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Jos\u00e9 P.","family":"Vaqu\u00e9","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Roc\u00edo","family":"Soldati","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Victoria","family":"Wargon","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Silvia I.","family":"Vanzulli","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Rub\u00e9n","family":"Martins","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Eduardo","family":"Zeitlin","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Alfredo A.","family":"Molinolo","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Luisa A.","family":"Helguero","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Caroline A.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"J. Silvio","family":"Gutkind","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]},{"given":"Claudia","family":"Lanari","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Institute of Experimental Biology and Medicine, IBYME-CONICET; 2National Academy of Medicine; 3Policl\u00ednica Bancaria, Buenos Aires, Argentina; 4Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, Maryland"}]}],"member":"1086","published-online":{"date-parts":[[2012,4,30]]},"reference":[{"key":"2022061703495668900_bib1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"2022061703495668900_bib2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1749-6632.2008.03685.x","article-title":"Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects","volume":"1155","author":"Santen","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"2022061703495668900_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3233\/BD-2006-24104","article-title":"Progestins and breast cancer","volume":"24","author":"Aupperlee","year":"2005","journal-title":"Breast Dis"},{"key":"2022061703495668900_bib4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/978-0-387-78818-0_7","article-title":"Progesterone receptor action: translating studies in breast cancer models to clinical insights","volume":"630","author":"Lange","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"2022061703495668900_bib5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.steroids.2007.12.023","article-title":"Challenges to defining a role for progesterone in breast cancer","volume":"73","author":"Lange","year":"2008","journal-title":"Steroids"},{"key":"2022061703495668900_bib6","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1210\/endo.134.2.7507831","article-title":"Regulation of progesterone receptor gene expression in MCF-7 breast cancer cells: a comparison of the effects of cyclic adenosine 3\u2032,5\u2032-monophosphate, estradiol, insulin-like growth factor-I, and serum factors","volume":"134","author":"Cho","year":"1994","journal-title":"Endocrinology"},{"key":"2022061703495668900_bib7","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1093\/emboj\/17.7.2008","article-title":"Activation of the Src\/p21ras\/Erk pathway by progesterone receptor via cross-talk with estrogen receptor","volume":"17","author":"Migliaccio","year":"1998","journal-title":"EMBO J"},{"key":"2022061703495668900_bib8","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1128\/MCB.23.6.1994-2008.2003","article-title":"Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src\/Erk pathway in mammalian cells","volume":"23","author":"Ballare","year":"2003","journal-title":"Mol Cell Biol"},{"key":"2022061703495668900_bib9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1097-2765(01)00304-5","article-title":"Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases","volume":"8","author":"Boonyaratanakornkit","year":"2001","journal-title":"Mol Cell"},{"key":"2022061703495668900_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1677\/ERC-08-0244","article-title":"The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer","volume":"16","author":"Lanari","year":"2009","journal-title":"Endocr Relat Cancer"},{"key":"2022061703495668900_bib11","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/0006-291X(87)91022-9","article-title":"Progestin effects on growth in the human breast cancer cell line T-47D\u2013possible therapeutic implications","volume":"145","author":"Hissom","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"key":"2022061703495668900_bib12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1210\/mend.13.6.0290","article-title":"Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals","volume":"13","author":"Lange","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib13","article-title":"Guide for the care and use of laboratory animals","author":"Institute of Laboratory Animal Resources CoLSNRC","year":"1996"},{"key":"2022061703495668900_bib14","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/jnci\/87.10.746","article-title":"Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer","volume":"87","author":"Osborne","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"2022061703495668900_bib15","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/ijc.23802","article-title":"Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2\/FGFR-2 axis","volume":"123","author":"Giulianelli","year":"2008","journal-title":"Int J Cancer"},{"key":"2022061703495668900_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1023324827225","article-title":"Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma","volume":"79","author":"Lamb","year":"2003","journal-title":"Breast Cancer Res Treat"},{"key":"2022061703495668900_bib17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10549-009-0659-8","article-title":"Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta?","volume":"123","author":"Soldati","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"2022061703495668900_bib18","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1158\/0008-5472.CAN-10-3074","article-title":"Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer","volume":"71","author":"Cerliani","year":"2011","journal-title":"Cancer Res"},{"key":"2022061703495668900_bib19","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nprot.2008.31","article-title":"Colocalization of fluorescent markers in confocal microscope images of plant cells","volume":"3","author":"French","year":"2008","journal-title":"Nat Protoc"},{"key":"2022061703495668900_bib20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1023\/A:1024029826248","article-title":"Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment","volume":"79","author":"Helguero","year":"2003","journal-title":"Breast Cancer Res Treat"},{"key":"2022061703495668900_bib21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10549-010-0971-3","article-title":"Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects","volume":"126","author":"Bottino","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"2022061703495668900_bib22","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.bcp.2005.03.028","article-title":"Transfection of adult primary rat hepatocytes in culture","volume":"69","author":"Gardmo","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"2022061703495668900_bib23","first-page":"529","article-title":"Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia","volume":"70","author":"Cerliani","year":"2010","journal-title":"Medicina (B Aires)"},{"key":"2022061703495668900_bib24","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1210\/me.2007-0101","article-title":"Steroid receptor phosphorylation: a key modulator of multiple receptor functions","volume":"21","author":"Weigel","year":"2007","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib25","first-page":"489","article-title":"Modulation of fibronectin expression and proteolytic activity associated with the invasive and metastatic phenotype in two new murine mammary tumor cell lines","volume":"3","author":"Urtreger","year":"1997","journal-title":"Int J Oncol"},{"key":"2022061703495668900_bib26","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1128\/MCB.00012-10","article-title":"Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3","volume":"30","author":"Beguelin","year":"2010","journal-title":"Mol Cell Biol"},{"key":"2022061703495668900_bib27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1210\/me.2006-0337","article-title":"The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle","volume":"21","author":"Boonyaratanakornkit","year":"2007","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib28","first-page":"3577","article-title":"Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression","volume":"13","author":"Musgrove","year":"1993","journal-title":"Mol Cell Biol"},{"key":"2022061703495668900_bib29","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1210\/en.2004-1535","article-title":"Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase\/Akt\/nuclear factor-kappaB cascade in human breast cancer cells","volume":"146","author":"Saitoh","year":"2005","journal-title":"Endocrinology"},{"key":"2022061703495668900_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1210\/me.2004-0306","article-title":"Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases","volume":"19","author":"Skildum","year":"2005","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0960-0760(97)00036-8","article-title":"A sequence in the 5\u2032 flanking region confers progestin responsiveness on the human c-myc gene","volume":"62","author":"Moore","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2022061703495668900_bib32","first-page":"5032","article-title":"Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes","volume":"11","author":"Musgrove","year":"1991","journal-title":"Mol Cell Biol"},{"key":"2022061703495668900_bib33","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1210\/me.2008-0347","article-title":"Mechanism of BRCA1-mediated inhibition of progesterone receptor transcriptional activity","volume":"23","author":"Katiyar","year":"2009","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib34","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1210\/me.2008-0454","article-title":"Mutational analysis of progesterone receptor functional domains in stable cell lines delineates sets of genes regulated by different mechanisms","volume":"23","author":"Quiles","year":"2009","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib35","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jsbmb.2009.05.013","article-title":"Potentiation of the antitumor effect of tamoxifen by combination with the antiprogestin onapristone","volume":"116","author":"Nishino","year":"2009","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2022061703495668900_bib36","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10549-008-0150-y","article-title":"Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas","volume":"116","author":"Wargon","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"2022061703495668900_bib37","first-page":"395","article-title":"Progestins inhibit the growth of MDA-MB-231 cells transfected with progesterone receptor complementary DNA","volume":"5","author":"Lin","year":"1999","journal-title":"Clin Cancer Res"},{"key":"2022061703495668900_bib38","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/jcp.10466","article-title":"Three novel hormone-responsive cell lines derived from primary human breast carcinomas: functional characterization","volume":"199","author":"Vazquez","year":"2004","journal-title":"J Cell Physiol"},{"key":"2022061703495668900_bib39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1677\/ERC-08-0281","article-title":"Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models","volume":"16","author":"Dressing","year":"2009","journal-title":"Endocr Relat Cancer"},{"key":"2022061703495668900_bib40","article-title":"Progesterone receptors, their isoforms and progesterone regulated transcription","author":"Jacobsen","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"2022061703495668900_bib41","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1210\/me.2011-1037","article-title":"Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor","volume":"25","author":"Wang","year":"2011","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib42","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1210\/me.2010-0027","article-title":"Minireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin","volume":"24","author":"Vicent","year":"2010","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1210\/me.2003-0331","article-title":"Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word?","volume":"18","author":"Lange","year":"2004","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib44","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1128\/MCB.24.16.7260-7274.2004","article-title":"Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun\/c-Fos\/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter","volume":"24","author":"Cicatiello","year":"2004","journal-title":"Mol Cell Biol"},{"key":"2022061703495668900_bib45","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.1210\/en.2008-0768","article-title":"Transcriptional response of the murine mammary gland to acute progesterone exposure","volume":"149","author":"Fernandez-Valdivia","year":"2008","journal-title":"Endocrinology"},{"key":"2022061703495668900_bib46","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1210\/me.2011-0064","article-title":"Progesterone receptor directly inhibits {beta}-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications","volume":"25","author":"Buser","year":"2011","journal-title":"Mol Endocrinol"},{"key":"2022061703495668900_bib47","doi-asserted-by":"crossref","first-page":"8217","DOI":"10.1158\/0008-5472.CAN-09-2223","article-title":"Nuclear receptor coregulators in cancer biology","volume":"69","author":"O'Malley","year":"2009","journal-title":"Cancer Res"},{"key":"2022061703495668900_bib48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2217\/17455057.4.2.151","article-title":"Progesterone and breast cancer.","volume":"4","author":"Lange","year":"2008","journal-title":"Womens Health (Lond Engl)"},{"key":"2022061703495668900_bib49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.pharmtox.48.113006.094649","article-title":"The c-MYC NHE III(1): function and regulation","volume":"50","author":"Gonzalez","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"}],"container-title":["Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article-pdf\/72\/9\/2416\/2683130\/2416.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article-pdf\/72\/9\/2416\/2683130\/2416.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T08:41:03Z","timestamp":1655455263000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/72\/9\/2416\/583999\/Estrogen-Receptor-Alpha-Mediates-Progestin-Induced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,30]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,4,30]]},"published-print":{"date-parts":[[2012,5,1]]}},"URL":"https:\/\/doi.org\/10.1158\/0008-5472.can-11-3290","relation":{"has-preprint":[{"id-type":"doi","id":"10.1158\/0008-5472.22395527","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395515","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395518","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395527.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395524.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395518.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395512.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.c.6504326","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395515.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395521.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.c.6504326.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395521","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395512","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22395524","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.717959376.793462786","asserted-by":"object"}]},"ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,30]]}}}