{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:53:06Z","timestamp":1772164386062,"version":"3.50.1"},"reference-count":30,"publisher":"American Association for Cancer Research (AACR)","issue":"12","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Overexpression of the prometastatic chromatin modifier protein metastasis tumor antigen 1 (MTA1) in human cancer contributes to tumor aggressiveness, but the role of endogenous MTA1 in cancer has not been explored. Here, we report the effects of selective genetic depletion of MTA1 in a physiologically relevant spontaneous mouse model of breast cancer pulmonary metastasis. We found that MTA1 acts as a mandatory modifier of breast-to-lung metastasis without effects on primary tumor formation. The underlying mechanism involved MTA1-dependent stimulation of STAT3 transcription through action on the MTA1\/STAT3\/Pol II coactivator complex, and, in turn, on the expression and functions of STAT3 target genes including Twist1. Accordingly, we documented a positive correlation between levels of MTA1 and STAT3 in publicly available breast cancer data sets. Together, our findings reveal an essential modifying role of the physiologic level of MTA1 in supporting pulmonary metastasis of breast cancer. Cancer Res; 73(12); 3761\u201370. \u00a92013 AACR.<\/jats:p>","DOI":"10.1158\/0008-5472.can-12-3998","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T21:33:52Z","timestamp":1365716032000},"page":"3761-3770","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer"],"prefix":"10.1158","volume":"73","author":[{"given":"Suresh B.","family":"Pakala","sequence":"first","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Suresh K.","family":"Rayala","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Rui-An","family":"Wang","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Kazufumi","family":"Ohshiro","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Prakriti","family":"Mudvari","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Sirigiri Divijendra Natha","family":"Reddy","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Ricardo","family":"Pires","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Sandra","family":"Casimiro","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"M. Radhakrishna","family":"Pillai","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Luis","family":"Costa","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"},{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"},{"name":"Authors' Affiliations:\u20081Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia; 2Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio; 3Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular-FML, Lisbon, Portugal; 4Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India; and 5Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas"}]}],"member":"1086","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"2022061703495904800_bib1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3","volume":"9","author":"Yu","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"2022061703495904800_bib2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological 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