{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:19:59Z","timestamp":1773044399122,"version":"3.50.1"},"reference-count":33,"publisher":"American Association for Cancer Research (AACR)","issue":"5","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tumor-infiltrating lymphocytes are key mediators of tumor immune surveillance and are important prognostic indicators in cancer progression. Among the various lymphocyte subsets implicated in protection against cancer are \u03b3\u03b4 T lymphocytes, which can kill tumor cells and secrete potent antitumor cytokines. By contrast, recent reports have revealed an unexpected series of protumor functions of \u03b3\u03b4 T cells in mouse models and human patients. In particular, specific \u03b3\u03b4 T-cell subsets are capable of recruiting immunosuppressive myeloid populations, inhibiting antitumor responses, and enhancing angiogenesis, thus promoting cancer progression. A common mediator of such functions appears to be the cytokine IL17, whose pathogenic effects can override the antitumor immune response orchestrated by IFN\u03b3. Here, we review these studies and discuss their implications for the manipulation of \u03b3\u03b4 T cells in cancer immunotherapy. Cancer Res; 75(5); 798\u2013802. \u00a92015 AACR.<\/jats:p>","DOI":"10.1158\/0008-5472.can-14-3228","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T05:30:15Z","timestamp":1423287015000},"page":"798-802","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["The Emerging Protumor Role of \u03b3\u03b4 T Lymphocytes: Implications for Cancer Immunotherapy"],"prefix":"10.1158","volume":"75","author":[{"given":"Margarida","family":"Rei","sequence":"first","affiliation":[{"name":"1Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Prof. Egas Moniz, Lisboa, Portugal."},{"name":"2Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom."},{"name":"3Graduate Program in Areas of Basic and Applied Biology, Universidade do Porto, Porto, Portugal."}]},{"given":"Daniel 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