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Herein, we have identified the presence of homozygous deletions of the candidate histone acetyltransferase KAT6B, and the loss of the corresponding transcript, in SCLC cell lines and primary tumors. Furthermore, we show, in vitro and in vivo, that the depletion of KAT6B expression enhances cancer growth, while its restoration induces tumor suppressor\u2013like features. Most importantly, we demonstrate that KAT6B exerts its tumor-inhibitory role through a newly defined type of histone H3 Lys23 acetyltransferase activity. Cancer Res; 75(18); 3936\u201345. \u00a92015 AACR.<\/jats:p>","DOI":"10.1158\/0008-5472.can-14-3702","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T23:14:51Z","timestamp":1437779691000},"page":"3936-3945","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer"],"prefix":"10.1158","volume":"75","author":[{"given":"Laia","family":"Sim\u00f3-Riudalbas","sequence":"first","affiliation":[{"name":"1Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain."}]},{"given":"Montserrat","family":"P\u00e9rez-Salvia","sequence":"additional","affiliation":[{"name":"1Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain."}]},{"given":"Fernando","family":"Setien","sequence":"additional","affiliation":[{"name":"1Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain."}]},{"given":"Alberto","family":"Villanueva","sequence":"additional","affiliation":[{"name":"2Translational Research Laboratory, Catalan Institute of Oncology (ICO), IDIBELL, Barcelona, Catalonia, Spain."}]},{"given":"Catia","family":"Moutinho","sequence":"additional","affiliation":[{"name":"1Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain."}]},{"given":"Anna","family":"Mart\u00ednez-Card\u00fas","sequence":"additional","affiliation":[{"name":"1Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, 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Spain."}]},{"given":"August","family":"Vidal","sequence":"additional","affiliation":[{"name":"5Department of Pathology, Bellvitge University Hospital, IDIBELL, Barcelona, Catalonia, Spain."}]},{"given":"Luca","family":"Roz","sequence":"additional","affiliation":[{"name":"6Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy."}]},{"given":"Ugo","family":"Pastorino","sequence":"additional","affiliation":[{"name":"7Thoracic Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy."}]},{"given":"Katalin","family":"Szakszon","sequence":"additional","affiliation":[{"name":"8Institute of Pediatrics, Clinical Genetics Center, University of Debrecen, Debrecen, Hungary."}]},{"given":"Guntram","family":"Borck","sequence":"additional","affiliation":[{"name":"9Institute of Human Genetics, University of Ulm, Ulm, Germany."}]},{"given":"Concei\u00e7\u00e3o 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