{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:53:58Z","timestamp":1772164438739,"version":"3.50.1"},"reference-count":50,"publisher":"American Association for Cancer Research (AACR)","issue":"18","funder":[{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute (NCI)","doi-asserted-by":"publisher","award":["U19-CA148112"],"award-info":[{"award-number":["U19-CA148112"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute (NCI)","doi-asserted-by":"publisher","award":["R01-CA149429"],"award-info":[{"award-number":["R01-CA149429"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute (NCI)","doi-asserted-by":"publisher","award":["R01-CA058598"],"award-info":[{"award-number":["R01-CA058598"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002879","name":"Canadian HIV Trials Network, Canadian Institutes of Health Research (CTN, CIHR)","doi-asserted-by":"publisher","award":["MOP-86727"],"award-info":[{"award-number":["MOP-86727"]}],"id":[{"id":"10.13039\/501100002879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001282","name":"Ovarian Cancer Research Fund (OCRF)","doi-asserted-by":"publisher","award":["OCRF"],"award-info":[{"award-number":["OCRF"]}],"id":[{"id":"10.13039\/100001282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute (NCI)","doi-asserted-by":"publisher","award":["1R01CA211574"],"award-info":[{"award-number":["1R01CA211574"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal genes underlying these associations remain largely unknown. Here, we performed a transcriptome-wide association study to search for novel genetic loci and plausible causal genes at known GWAS loci. We used RNA sequencing data (68 normal ovarian tissue samples from 68 individuals and 6,124 cross-tissue samples from 369 individuals) and high-density genotyping data from European descendants of the Genotype-Tissue Expression (GTEx V6) project to build ovarian and cross-tissue models of genetically regulated expression using elastic net methods. We evaluated 17,121 genes for their cis-predicted gene expression in relation to EOC risk using summary statistics data from GWAS of 97,898 women, including 29,396 EOC cases. With a Bonferroni-corrected significance level of P &amp;lt; 2.2 \u00d7 10\u22126, we identified 35 genes, including FZD4 at 11q14.2 (Z = 5.08, P = 3.83 \u00d7 10\u22127, the cross-tissue model; 1 Mb away from any GWAS-identified EOC risk variant), a potential novel locus for EOC risk. All other 34 significantly associated genes were located within 1 Mb of known GWAS-identified loci, including 23 genes at 6 loci not previously linked to EOC risk. Upon conditioning on nearby known EOC GWAS-identified variants, the associations for 31 genes disappeared and three genes remained (P &amp;lt; 1.47 \u00d7 10\u22123). These data identify one novel locus (FZD4) and 34 genes at 13 known EOC risk loci associated with EOC risk, providing new insights into EOC carcinogenesis.<\/jats:p>\n                  <jats:p>Significance: Transcriptomic analysis of a large cohort confirms earlier GWAS loci and reveals FZD4 as a novel locus associated with EOC risk. Cancer Res; 78(18); 5419\u201330. \u00a92018 AACR.<\/jats:p>","DOI":"10.1158\/0008-5472.can-18-0951","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T10:25:24Z","timestamp":1532687124000},"page":"5419-5430","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk"],"prefix":"10.1158","volume":"78","author":[{"given":"Yingchang","family":"Lu","sequence":"first","affiliation":[{"name":"1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee."}]},{"given":"Alicia","family":"Beeghly-Fadiel","sequence":"additional","affiliation":[{"name":"1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee."}]},{"given":"Lang","family":"Wu","sequence":"additional","affiliation":[{"name":"1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee."}]},{"given":"Xingyi","family":"Guo","sequence":"additional","affiliation":[{"name":"1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee."}]},{"given":"Bingshan","family":"Li","sequence":"additional","affiliation":[{"name":"2Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee."}]},{"given":"Joellen M.","family":"Schildkraut","sequence":"additional","affiliation":[{"name":"3Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia."}]},{"given":"Hae Kyung","family":"Im","sequence":"additional","affiliation":[{"name":"4Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois."}]},{"given":"Yian A.","family":"Chen","sequence":"additional","affiliation":[{"name":"5Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-9264","authenticated-orcid":false,"given":"Jennifer B.","family":"Permuth","sequence":"additional","affiliation":[{"name":"6Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida."}]},{"given":"Brett M.","family":"Reid","sequence":"additional","affiliation":[{"name":"6Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-0282","authenticated-orcid":false,"given":"Jamie K.","family":"Teer","sequence":"additional","affiliation":[{"name":"5Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida."}]},{"given":"Kirsten B.","family":"Moysich","sequence":"additional","affiliation":[{"name":"7Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York."}]},{"given":"Irene L.","family":"Andrulis","sequence":"additional","affiliation":[{"name":"8Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada."},{"name":"9Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada."}]},{"given":"Hoda","family":"Anton-Culver","sequence":"additional","affiliation":[{"name":"10Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, California."}]},{"given":"Banu K.","family":"Arun","sequence":"additional","affiliation":[{"name":"11Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas."}]},{"given":"Elisa V.","family":"Bandera","sequence":"additional","affiliation":[{"name":"12Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey."}]},{"given":"Rosa B.","family":"Barkardottir","sequence":"additional","affiliation":[{"name":"13Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland."},{"name":"14BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-7570","authenticated-orcid":false,"given":"Daniel R.","family":"Barnes","sequence":"additional","affiliation":[{"name":"15Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom."}]},{"given":"Javier","family":"Benitez","sequence":"additional","affiliation":[{"name":"16Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain."},{"name":"17Centro de Investigaci\u00f3n en Red de Enfermedades Raras (CIBERER), Valencia, Spain."}]},{"given":"Line","family":"Bjorge","sequence":"additional","affiliation":[{"name":"18Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway."},{"name":"19Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway."}]},{"given":"James","family":"Brenton","sequence":"additional","affiliation":[{"name":"20Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom."}]},{"given":"Ralf","family":"Butzow","sequence":"additional","affiliation":[{"name":"21Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1038-5392","authenticated-orcid":false,"given":"Trinidad","family":"Caldes","sequence":"additional","affiliation":[{"name":"22Medical Oncology Department, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Centro Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0589-1829","authenticated-orcid":false,"given":"Maria A.","family":"Caligo","sequence":"additional","affiliation":[{"name":"23Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy."}]},{"given":"Ian","family":"Campbell","sequence":"additional","affiliation":[{"name":"24Peter MacCallum Cancer Center, Melbourne, Victoria, Australia."},{"name":"25Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia."},{"name":"26Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8919-1971","authenticated-orcid":false,"given":"Jenny","family":"Chang-Claude","sequence":"additional","affiliation":[{"name":"27Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."},{"name":"28Research Group Genetic Cancer Epidemiology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}]},{"given":"Kathleen B.M.","family":"Claes","sequence":"additional","affiliation":[{"name":"29Centre for Medical Genetics, Ghent University, Gent, Belgium."}]},{"given":"Fergus J.","family":"Couch","sequence":"additional","affiliation":[{"name":"30Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."}]},{"given":"Daniel W.","family":"Cramer","sequence":"additional","affiliation":[{"name":"31Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts."},{"name":"32Harvard T.H. Chan School of Public Health, Boston, Massachusetts."}]},{"given":"Mary B.","family":"Daly","sequence":"additional","affiliation":[{"name":"33Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-4744","authenticated-orcid":false,"given":"Anna","family":"deFazio","sequence":"additional","affiliation":[{"name":"34Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia."},{"name":"35Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1214","authenticated-orcid":false,"given":"Joe","family":"Dennis","sequence":"additional","affiliation":[{"name":"15Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom."}]},{"given":"Orland","family":"Diez","sequence":"additional","affiliation":[{"name":"36Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Barcelona, Spain."}]},{"given":"Susan M.","family":"Domchek","sequence":"additional","affiliation":[{"name":"37Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania."}]},{"given":"Thilo","family":"D\u00f6rk","sequence":"additional","affiliation":[{"name":"38Gynaecology Research Unit, Hannover Medical School, Hannover, Germany."}]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[{"name":"15Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom."},{"name":"39Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom."}]},{"given":"Diana M.","family":"Eccles","sequence":"additional","affiliation":[{"name":"40Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-8471","authenticated-orcid":false,"given":"Peter A.","family":"Fasching","sequence":"additional","affiliation":[{"name":"41Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany."},{"name":"42David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-8505","authenticated-orcid":false,"given":"Ren\u00e9e T.","family":"Fortner","sequence":"additional","affiliation":[{"name":"27Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"George","family":"Fountzilas","sequence":"additional","affiliation":[{"name":"43Department of Medical Oncology, \u201cPapageorgiou\u201d Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece."}]},{"given":"Eitan","family":"Friedman","sequence":"additional","affiliation":[{"name":"44The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel."},{"name":"45Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel."}]},{"given":"Patricia A.","family":"Ganz","sequence":"additional","affiliation":[{"name":"46Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, California."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-3982","authenticated-orcid":false,"given":"Judy","family":"Garber","sequence":"additional","affiliation":[{"name":"47Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-9099","authenticated-orcid":false,"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[{"name":"48Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia."},{"name":"49Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia."},{"name":"50Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia."}]},{"given":"Andrew K.","family":"Godwin","sequence":"additional","affiliation":[{"name":"51Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas."}]},{"given":"David E.","family":"Goldgar","sequence":"additional","affiliation":[{"name":"52Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah."}]},{"given":"Marc T.","family":"Goodman","sequence":"additional","affiliation":[{"name":"53Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California."},{"name":"54Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-9239","authenticated-orcid":false,"given":"Mark H.","family":"Greene","sequence":"additional","affiliation":[{"name":"55Clinical Genetics Branch, DCEG, National Cancer Institute, Bethesda, Maryland."}]},{"given":"Jacek","family":"Gronwald","sequence":"additional","affiliation":[{"name":"56Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland."}]},{"given":"Ute","family":"Hamann","sequence":"additional","affiliation":[{"name":"57Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"Florian","family":"Heitz","sequence":"additional","affiliation":[{"name":"58Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany."},{"name":"59Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte\/Evang. Huyssens-Stiftung\/Knappschaft GmbH, Essen, Germany."}]},{"given":"Michelle A.T.","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"60Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas."}]},{"given":"Claus K.","family":"H\u00f8gdall","sequence":"additional","affiliation":[{"name":"61Department of Gynecology, The Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark."}]},{"given":"Antoinette","family":"Hollestelle","sequence":"additional","affiliation":[{"name":"62Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8397-4078","authenticated-orcid":false,"given":"Peter J.","family":"Hulick","sequence":"additional","affiliation":[{"name":"63Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois."},{"name":"64The University of Chicago Pritzker School of Medicine, Chicago, Illinois."}]},{"given":"David G.","family":"Huntsman","sequence":"additional","affiliation":[{"name":"65British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver General Hospital, BC Cancer Agency and University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"66Department of Molecular Oncology, BC Cancer Agency Research Centre, Vancouver, British Columbia, Canada."},{"name":"67Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}]},{"given":"Evgeny N.","family":"Imyanitov","sequence":"additional","affiliation":[{"name":"68N.N. Petrov Institute of Oncology, St. Petersburg, Russia."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-1260","authenticated-orcid":false,"given":"Claudine","family":"Isaacs","sequence":"additional","affiliation":[{"name":"69Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia."}]},{"given":"Anna","family":"Jakubowska","sequence":"additional","affiliation":[{"name":"56Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-4657","authenticated-orcid":false,"given":"Paul","family":"James","sequence":"additional","affiliation":[{"name":"25Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia."},{"name":"70Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia."}]},{"given":"Beth Y.","family":"Karlan","sequence":"additional","affiliation":[{"name":"71Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California."}]},{"given":"Linda E.","family":"Kelemen","sequence":"additional","affiliation":[{"name":"72Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-1326","authenticated-orcid":false,"given":"Lambertus A.","family":"Kiemeney","sequence":"additional","affiliation":[{"name":"73Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-1398","authenticated-orcid":false,"given":"Susanne K.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"74Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark."},{"name":"75Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark."}]},{"given":"Ava","family":"Kwong","sequence":"additional","affiliation":[{"name":"76Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong."},{"name":"77Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong."},{"name":"78Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong."}]},{"given":"Nhu D.","family":"Le","sequence":"additional","affiliation":[{"name":"79Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-6222","authenticated-orcid":false,"given":"Goska","family":"Leslie","sequence":"additional","affiliation":[{"name":"15Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-4549","authenticated-orcid":false,"given":"Fabienne","family":"Lesueur","sequence":"additional","affiliation":[{"name":"80Genetic Epidemiology of Cancer team, Inserm U900, Paris, France."},{"name":"81Institut Curie, Paris, France."},{"name":"82PSL University, Paris, France."},{"name":"83Mines ParisTech, Fontainebleau, France."}]},{"given":"Douglas A.","family":"Levine","sequence":"additional","affiliation":[{"name":"84Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York."},{"name":"85Gynecologic Oncology, Laura and Isaac Pearlmutter Cancer Center, NYU Langone Medical Center, New York, New York."}]},{"given":"Amalia","family":"Mattiello","sequence":"additional","affiliation":[{"name":"86Dipertimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy."}]},{"given":"Taymaa","family":"May","sequence":"additional","affiliation":[{"name":"87Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada."}]},{"given":"Lesley","family":"McGuffog","sequence":"additional","affiliation":[{"name":"15Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-7586","authenticated-orcid":false,"given":"Iain A.","family":"McNeish","sequence":"additional","affiliation":[{"name":"88Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Glasgow, United Kingdom."}]},{"given":"Melissa A.","family":"Merritt","sequence":"additional","affiliation":[{"name":"89Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii."},{"name":"90Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom."}]},{"given":"Francesmary","family":"Modugno","sequence":"additional","affiliation":[{"name":"91Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania."},{"name":"92Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania."},{"name":"93Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania."}]},{"given":"Marco","family":"Montagna","sequence":"additional","affiliation":[{"name":"94Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy."}]},{"given":"Susan L.","family":"Neuhausen","sequence":"additional","affiliation":[{"name":"95Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-2976","authenticated-orcid":false,"given":"Heli","family":"Nevanlinna","sequence":"additional","affiliation":[{"name":"96Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland."}]},{"given":"Finn C.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"97Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark."}]},{"given":"Liene","family":"Nikitina-Zake","sequence":"additional","affiliation":[{"name":"98Latvian Biomedical Research and Study Centre, Riga, Latvia."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-8880","authenticated-orcid":false,"given":"Robert L.","family":"Nussbaum","sequence":"additional","affiliation":[{"name":"99Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, California."}]},{"given":"Kenneth","family":"Offit","sequence":"additional","affiliation":[{"name":"100Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York."},{"name":"101Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York."}]},{"given":"Edith","family":"Olah","sequence":"additional","affiliation":[{"name":"102Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary."}]},{"given":"Olufunmilayo I.","family":"Olopade","sequence":"additional","affiliation":[{"name":"103Center for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois."}]},{"given":"Sara H.","family":"Olson","sequence":"additional","affiliation":[{"name":"104Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York."}]},{"given":"H\u00e5kan","family":"Olsson","sequence":"additional","affiliation":[{"name":"105Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden."}]},{"given":"Ana","family":"Osorio","sequence":"additional","affiliation":[{"name":"16Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain."},{"name":"106Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5002-9707","authenticated-orcid":false,"given":"Sue K.","family":"Park","sequence":"additional","affiliation":[{"name":"107Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea."},{"name":"108Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea."},{"name":"109Cancer Research Institute, Seoul National University, Seoul, Korea."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-8477","authenticated-orcid":false,"given":"Michael T.","family":"Parsons","sequence":"additional","affiliation":[{"name":"110Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia."}]},{"given":"Petra H.M.","family":"Peeters","sequence":"additional","affiliation":[{"name":"111Julius Center for Health Sciences and Primary Care, UMC Utrecht, University Utrecht, Utrecht, The Netherlands."}]},{"given":"Tanja","family":"Pejovic","sequence":"additional","affiliation":[{"name":"112Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon."},{"name":"113Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6951-6855","authenticated-orcid":false,"given":"Paolo","family":"Peterlongo","sequence":"additional","affiliation":[{"name":"114IFOM, the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy."}]},{"given":"Catherine 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