{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:14:39Z","timestamp":1740143679560,"version":"3.37.3"},"reference-count":9,"publisher":"American Association for Cancer Research (AACR)","issue":"9","funder":[{"DOI":"10.13039\/100000002","name":"NIH NCI","doi-asserted-by":"publisher","award":["R01CA213233","R01CA1957330","P01CA117969"],"award-info":[{"award-number":["R01CA213233","R01CA1957330","P01CA117969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The intercellular exchange of exosomes may play a regulatory function in tumor progression and metastasis. Maziveyi and colleagues demonstrated that Nischarin regulated the secretion of exosomes from breast cancer cells. Loss of Nischarin expression increased exosome production and promoted tumor cell growth and migration, supporting that Nischarin can influence the behavior of surrounding cancer cells. This study identified a novel function of the tumor suppressor Nischarin in exosome biology and cancer progression.<\/jats:p>\n               <jats:p>See related article by Maziveyi et al., p. 2152<\/jats:p>","DOI":"10.1158\/0008-5472.can-19-0387","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T12:45:16Z","timestamp":1556714716000},"page":"2099-2101","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nischarin Regulates Secretion of Exosomes and Cancer Progression"],"prefix":"10.1158","volume":"79","author":[{"given":"Kathleen M.","family":"McAndrews","sequence":"first","affiliation":[{"name":"Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas."}]},{"given":"Raghu","family":"Kalluri","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas."}]}],"member":"1086","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"2022061706271075500_bib1","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-18-0842","article-title":"Exosomes from Nischarin-expressing cells reduce breast cancer cell motility and tumor growth","author":"Maziveyi","year":"2019","journal-title":"Cancer Res"},{"key":"2022061706271075500_bib2","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1158\/0008-5472.CAN-15-1395","article-title":"Breast cancer tumor suppressors: a special emphasis on novel protein nischarin","volume":"75","author":"Maziveyi","year":"2015","journal-title":"Cancer Res"},{"key":"2022061706271075500_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2022061706271075500_bib4","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI81135","article-title":"The biology and function of exosomes in cancer","volume":"126","author":"Kalluri","year":"2016","journal-title":"J Clin Invest"},{"key":"2022061706271075500_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.bbrc.2014.07.109","article-title":"Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells","volume":"451","author":"Lee","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"2022061706271075500_bib6","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1158\/0008-5472.CAN-05-4579","article-title":"The regulation of exosome secretion: a novel function of the p53 protein","volume":"66","author":"Yu","year":"2006","journal-title":"Cancer Res"},{"key":"2022061706271075500_bib7","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"2022061706271075500_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcancer.2014.04.009","article-title":"Sorting it out: Regulation of exosome loading","volume":"28","author":"Villarroya-Beltri","year":"2014","journal-title":"Semin Cancer Biol"},{"key":"2022061706271075500_bib9","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat Med"}],"container-title":["Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article-pdf\/79\/9\/2099\/2789994\/2099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article-pdf\/79\/9\/2099\/2789994\/2099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T18:33:48Z","timestamp":1655490828000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/79\/9\/2099\/640525\/Nischarin-Regulates-Secretion-of-Exosomes-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,5,1]]},"published-print":{"date-parts":[[2019,5,1]]}},"URL":"https:\/\/doi.org\/10.1158\/0008-5472.can-19-0387","relation":{},"ISSN":["0008-5472","1538-7445"],"issn-type":[{"type":"print","value":"0008-5472"},{"type":"electronic","value":"1538-7445"}],"subject":[],"published":{"date-parts":[[2019,5,1]]}}}