{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:16:32Z","timestamp":1776755792427,"version":"3.51.2"},"reference-count":51,"publisher":"American Association for Cancer Research (AACR)","issue":"10","funder":[{"DOI":"10.13039\/100005921","name":"IARC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH NCI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Epigenetic mechanisms such as aberrant DNA methylation (DNAme) are known to drive esophageal squamous cell carcinoma (ESCC), yet they remain poorly understood. Here, we studied tumor-specific DNAme in ESCC cases from nine high-incidence countries of Africa, Asia, and South America. Infinium MethylationEPIC array was performed on 108 tumors and 51 normal tissues adjacent to the tumors (NAT) in the discovery phase, and targeted pyrosequencing was performed on 132 tumors and 36 NAT in the replication phase. Top genes for replication were prioritized by weighting methylation results using RNA-sequencing data from The Cancer Genome Atlas and GTEx and validated by qPCR. Methylome analysis comparing tumor and NAT identified 6,796 differentially methylated positions (DMP) and 866 differential methylated regions (DMR), with a 30% methylation (\u0394\u03b2) difference. The majority of identified DMPs and DMRs were hypermethylated in tumors, particularly in promoters and gene-body regions of genes involved in transcription activation. The top three prioritized genes for replication, PAX9, SIM2, and THSD4, had similar methylation differences in the discovery and replication sets. These genes were exclusively expressed in normal esophageal tissues in GTEx and downregulated in tumors. The specificity and sensitivity of these DNAme events in discriminating tumors from NAT were assessed. Our study identified novel, robust, and crucial tumor-specific DNAme events in ESCC tumors across several high-incidence populations of the world. Methylome changes identified in this study may serve as potential targets for biomarker discovery and warrant further functional characterization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>This largest genome-wide DNA methylation study on ESCC from high-incidence populations of the world identifies functionally relevant and robust DNAme events that could serve as potential tumor-specific markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1158\/0008-5472.can-20-3445","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T17:35:33Z","timestamp":1616175333000},"page":"2612-2624","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers"],"prefix":"10.1158","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-5543","authenticated-orcid":false,"given":"Fazlur Rahman","family":"Talukdar","sequence":"first","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3708","authenticated-orcid":false,"given":"Sheila C.","family":"Soares Lima","sequence":"additional","affiliation":[{"name":"2Department of Molecular Carcinogenesis, Brazilian National Cancer Institute, Rio de Janeiro, Brazil."}]},{"given":"Rita","family":"Khoueiry","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-094X","authenticated-orcid":false,"given":"Ruhina Shirin","family":"Laskar","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"given":"Cyrille","family":"Cuenin","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-8236","authenticated-orcid":false,"given":"Bruna Pereira","family":"Sorroche","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."},{"name":"3Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil."}]},{"given":"Anne-Claire","family":"Boisson","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"given":"Behnoush","family":"Abedi-Ardekani","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"given":"Christine","family":"Carreira","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"given":"Diana","family":"Menya","sequence":"additional","affiliation":[{"name":"4Moi University, Eldoret, Kenya."}]},{"given":"Charles P.","family":"Dzamalala","sequence":"additional","affiliation":[{"name":"5University of Malawi, Blantyre, Malawi."}]},{"given":"Mathewos","family":"Assefa","sequence":"additional","affiliation":[{"name":"6Addis Ababa University, Addis Ababa, Ethiopia."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8028-1150","authenticated-orcid":false,"given":"Abraham","family":"Aseffa","sequence":"additional","affiliation":[{"name":"7Armauer Hansen Research Institute, Addis Ababa, Ethiopia."}]},{"given":"Vera","family":"Miranda-Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"8Department of Pathology and Cancer Biology and Epigenetics Group, Portuguese Oncology Institute of Porto and Biomedical Sciences Institute of University of Porto, Porto, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-5345","authenticated-orcid":false,"given":"Carmen","family":"Jer\u00f3nimo","sequence":"additional","affiliation":[{"name":"8Department of Pathology and Cancer Biology and Epigenetics Group, Portuguese Oncology Institute of Porto and Biomedical Sciences Institute of University of Porto, Porto, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-4666","authenticated-orcid":false,"given":"Rui M.","family":"Henrique","sequence":"additional","affiliation":[{"name":"8Department of Pathology and Cancer Biology and Epigenetics Group, Portuguese Oncology Institute of Porto and Biomedical Sciences Institute of University of Porto, Porto, Portugal."}]},{"given":"Ramin","family":"Shakeri","sequence":"additional","affiliation":[{"name":"9Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-6335","authenticated-orcid":false,"given":"Reza","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"9Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran."}]},{"given":"Nagla","family":"Gasmelseed","sequence":"additional","affiliation":[{"name":"10Department of Molecular Biology, National Cancer Institute, University of Gezira, Gezira, Sudan."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8380-0227","authenticated-orcid":false,"given":"Mona","family":"Ellaithi","sequence":"additional","affiliation":[{"name":"11Department of Histopathology and Cytology, Al-Neelain University, Khartoum, Sudan."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-4215","authenticated-orcid":false,"given":"Nitin","family":"Gangane","sequence":"additional","affiliation":[{"name":"12Mahatma Gandhi Institute of Medical Sciences, Sevagram, India."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-8610","authenticated-orcid":false,"given":"Daniel R.S.","family":"Middleton","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"given":"Florence","family":"Le Calvez-Kelm","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-6402","authenticated-orcid":false,"given":"Akram","family":"Ghantous","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"given":"Maria Leon","family":"Roux","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9687-2134","authenticated-orcid":false,"given":"Joachim","family":"Sch\u00fcz","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7397-3442","authenticated-orcid":false,"given":"Valerie","family":"McCormack","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-3825","authenticated-orcid":false,"given":"M. Iqbal","family":"Parker","sequence":"additional","affiliation":[{"name":"13Integrative Biomedical Sciences and IDM, University of Cape Town, Cape Town, South Africa."}]},{"given":"Luis Felipe Ribeiro","family":"Pinto","sequence":"additional","affiliation":[{"name":"2Department of Molecular Carcinogenesis, Brazilian National Cancer Institute, Rio de Janeiro, Brazil."}]},{"given":"Zdenko","family":"Herceg","sequence":"additional","affiliation":[{"name":"1International Agency for Research on Cancer, Lyon, France."}]}],"member":"1086","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"2022061706370908200_bib1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2022061706370908200_bib2","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ajg.2017.155","article-title":"Predicting the future burden of esophageal cancer by histological subtype: international trends in incidence up to 2030","volume":"112","author":"Arnold","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"2022061706370908200_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/ijc.30292","article-title":"Informing etiologic research priorities for squamous cell esophageal cancer in Africa: a review of setting-specific exposures to known and putative risk factors","volume":"140","author":"McCormack","year":"2017","journal-title":"Int J Cancer"},{"key":"2022061706370908200_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13148-016-0210-9","article-title":"The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma","volume":"8","author":"Ma","year":"2016","journal-title":"Clin Epigenetics"},{"key":"2022061706370908200_bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1399-0004.2011.01809.x","article-title":"Epigenetic modifications in cancer","volume":"81","author":"Kanwal","year":"2012","journal-title":"Clin Genet"},{"key":"2022061706370908200_bib6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.4161\/epi.6.10.17199","article-title":"Identification of a DNA methylome signature of esophageal squamous cell carcinoma and potential epigenetic biomarkers","volume":"6","author":"Lima","year":"2011","journal-title":"Epigenetics"},{"key":"2022061706370908200_bib7","doi-asserted-by":"crossref","first-page":"e103162","DOI":"10.1371\/journal.pone.0103162","article-title":"Identification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"2022061706370908200_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","article-title":"Integrated genomic characterization of oesophageal carcinoma","volume":"541","author":"Cancer Genome Atlas Research Network; Analysis Working Group: Asan University; BC Cancer Agency; Brigham and Women's Hospital; Broad Institute; Brown University","year":"2017","journal-title":"Nature"},{"key":"2022061706370908200_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.canep.2018.09.006","article-title":"Cancer epidemiology fieldwork in a resource-limited setting: experience from the western Kenya ESCCAPE esophageal cancer case\u2013control pilot study","volume":"57","author":"Menya","year":"2018","journal-title":"Cancer Epidemiol"},{"key":"2022061706370908200_bib10","doi-asserted-by":"crossref","first-page":"16634","DOI":"10.18632\/oncotarget.24621","article-title":"Esophageal squamous cell carcinoma transcriptome reveals the effect of FOXM1 on patient outcome through novel PIK3R3 mediated activation of PI3K signaling pathway","volume":"9","author":"Nicolau-Neto","year":"2018","journal-title":"Oncotarget"},{"key":"2022061706370908200_bib11","doi-asserted-by":"crossref","first-page":"e0178911","DOI":"10.1371\/journal.pone.0178911","article-title":"Qat use and esophageal cancer in Ethiopia: a pilot case\u2013control study","volume":"12","author":"Leon","year":"2017","journal-title":"PLoS ONE"},{"key":"2022061706370908200_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-7659-1_2","article-title":"Whole genome DNA methylation analysis of human glioblastoma using Illumina BEADARRAYS","volume":"1741","author":"Serrano","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2022061706370908200_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13148-017-0333-7","article-title":"Validation of the MethylationEPIC BeadChip for fresh-frozen and formalin-fixed paraffin-embedded tumours","volume":"9","author":"Kling","year":"2017","journal-title":"Clin Epigenetics"},{"key":"2022061706370908200_bib14","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","article-title":"Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi","volume":"33","author":"Fortin","year":"2017","journal-title":"Bioinformatics"},{"key":"2022061706370908200_bib15","first-page":"e22","article-title":"Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes","volume":"45","author":"Zhou","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2022061706370908200_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4161\/epi.23470","article-title":"Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium human methylation 450 microarray","volume":"8","author":"Chen","year":"2013","journal-title":"Epigenetics"},{"key":"2022061706370908200_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13073-020-0716-9","article-title":"Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age","volume":"12","author":"Merid","year":"2020","journal-title":"Genome Med"},{"key":"2022061706370908200_bib18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2105-11-587","article-title":"Comparison of beta-value and M-value methods for quantifying methylation levels by microarray analysis","volume":"11","author":"Du","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2022061706370908200_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s12967-019-2090-1","article-title":"DNA methylation exploration for ARDS: a multi-omics and multi-microarray interrelated analysis","volume":"17","author":"Zhang","year":"2019","journal-title":"J Transl Med"},{"key":"2022061706370908200_bib20","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2022061706370908200_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"key":"2022061706370908200_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8935-8-6","article-title":"De novo identification of differentially methylated regions in the human genome","volume":"8","author":"Peters","year":"2015","journal-title":"Epigenetics Chromatin"},{"key":"2022061706370908200_bib23","doi-asserted-by":"crossref","first-page":"e1006701","DOI":"10.1371\/journal.pcbi.1006701","article-title":"New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx","volume":"15","author":"Mounir","year":"2019","journal-title":"PLoS Comput Biol"},{"key":"2022061706370908200_bib24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/978-1-4939-7481-8_22","article-title":"Quantitative DNA methylation analysis at single-nucleotide resolution by pyrosequencing(R)","volume":"1708","author":"Busato","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2022061706370908200_bib25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-4939-3444-7_6","article-title":"Quantification of mRNA levels using real-time polymerase chain reaction (pCR)","volume":"1406","author":"Li","year":"2016","journal-title":"Breast Cancer"},{"key":"2022061706370908200_bib26","first-page":"581","article-title":"Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach","volume":"112","author":"Perez-Enciso","year":"2003","journal-title":"Hum Genet"},{"key":"2022061706370908200_bib27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13059-016-1066-1","article-title":"Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling","volume":"17","author":"Pidsley","year":"2016","journal-title":"Genome Biol"},{"key":"2022061706370908200_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s13059-014-0469-0","article-title":"Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes","volume":"15","author":"Blattler","year":"2014","journal-title":"Genome Biol"},{"key":"2022061706370908200_bib29","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/s41598-020-58331-w","article-title":"DNA sequence context as a marker of CpG methylation instability in normal and cancer tissues","volume":"10","author":"Scala","year":"2020","journal-title":"Sci Rep"},{"key":"2022061706370908200_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5732\/cjc.011.10381","article-title":"Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma","volume":"32","author":"Li","year":"2013","journal-title":"Chin J Cancer"},{"key":"2022061706370908200_bib31","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/mc.22452","article-title":"Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma","volume":"55","author":"Kishino","year":"2016","journal-title":"Mol Carcinog"},{"key":"2022061706370908200_bib32","doi-asserted-by":"crossref","first-page":"e60996","DOI":"10.1371\/journal.pone.0060996","article-title":"Epigenetic, genetic and environmental interactions in esophageal squamous cell carcinoma from northeast India","volume":"8","author":"Talukdar","year":"2013","journal-title":"PLoS One"},{"key":"2022061706370908200_bib33","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1038\/s41467-018-05550-5","article-title":"Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer","volume":"9","author":"Arechederra","year":"2018","journal-title":"Nat Commun"},{"key":"2022061706370908200_bib34","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.18632\/oncotarget.6607","article-title":"Genome-wide profiling of DNA methylation and gene expression in esophageal squamous cell carcinoma","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"2022061706370908200_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2199-11-9","article-title":"Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells","volume":"11","author":"Belanger","year":"2010","journal-title":"BMC Mol Biol"},{"key":"2022061706370908200_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-019-0081-6","article-title":"Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers","volume":"4","author":"Xu","year":"2019","journal-title":"Signal Transduct Target Ther"},{"key":"2022061706370908200_bib37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/cge.12986","article-title":"PAX9 gene mutations and tooth agenesis: a review","volume":"92","author":"Bonczek","year":"2017","journal-title":"Clin Genet"},{"key":"2022061706370908200_bib38","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4103\/0973-1482.168997","article-title":"Tooth agenesis: a susceptible indicator for colorectal cancer?","volume":"14","author":"Paranjyothi","year":"2018","journal-title":"J Cancer Res Ther"},{"key":"2022061706370908200_bib39","doi-asserted-by":"crossref","first-page":"707","DOI":"10.5603\/GP.2019.0121","article-title":"Coexistence of tooth agenesis and ovarian cancer\u2014a systematic literature review","volume":"90","author":"Gawron-Jakubek","year":"2019","journal-title":"Ginekol Pol"},{"key":"2022061706370908200_bib40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3748\/wjg.v25.i2.233","article-title":"Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett's esophagus","volume":"25","author":"Lv","year":"2019","journal-title":"World J Gastroenterol"},{"key":"2022061706370908200_bib41","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/path.4998","article-title":"PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium","volume":"244","author":"Xiong","year":"2018","journal-title":"J Pathol"},{"key":"2022061706370908200_bib42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/path.1115","article-title":"Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus","volume":"197","author":"Gerber","year":"2002","journal-title":"J Pathol"},{"key":"2022061706370908200_bib43","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/cas.13531","article-title":"Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications","volume":"109","author":"Tamaoki","year":"2018","journal-title":"Cancer Sci"},{"key":"2022061706370908200_bib44","first-page":"835","article-title":"CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer","volume":"56","author":"Takashima","year":"2020","journal-title":"Int J Oncol"},{"key":"2022061706370908200_bib45","doi-asserted-by":"crossref","first-page":"2968106","DOI":"10.1155\/2016\/2968106","article-title":"Identification of the key genes and pathways in esophageal carcinoma","volume":"2016","author":"Su","year":"2016","journal-title":"Gastroenterol Res Pract"},{"key":"2022061706370908200_bib46","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/ajmg.a.38350","article-title":"Whole exome sequencing identified genetic variations in Chinese hemangioblastoma patients","volume":"173","author":"Ma","year":"2017","journal-title":"Am J Med Genet A"},{"key":"2022061706370908200_bib47","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.neo.2019.08.004","article-title":"Rectal cancer sub-clones respond differentially to neoadjuvant therapy","volume":"21","author":"Frydrych","year":"2019","journal-title":"Neoplasia"},{"key":"2022061706370908200_bib48","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2147\/CMAR.S184368","article-title":"Loss of KCNJ15 expression promotes malignant phenotypes and correlates with poor prognosis in renal carcinoma","volume":"11","author":"Liu","year":"2019","journal-title":"Cancer Manag Res"},{"key":"2022061706370908200_bib49","first-page":"1821","article-title":"Extracellular vesicle delivered miR5055p, as a diagnostic biomarker of early lung adenocarcinoma, inhibits cell apoptosis by targeting TP53AIP1","volume":"54","author":"Fang","year":"2019","journal-title":"Int J Oncol"},{"key":"2022061706370908200_bib50","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cgh.2018.07.043","article-title":"Safety and acceptability of esophageal cytosponge cell collection device in a pooled analysis of data from individual patients","volume":"17","author":"Januszewicz","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2022061706370908200_bib51","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/ijc.33366","article-title":"Minimally invasive esophageal sponge cytology sampling is feasible in a Tanzanian community setting","volume":"148","author":"Middleton","year":"2021","journal-title":"Int J Cancer"}],"container-title":["Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article-pdf\/81\/10\/2612\/3082405\/2612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article-pdf\/81\/10\/2612\/3082405\/2612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:39:09Z","timestamp":1698057549000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/81\/10\/2612\/665612\/Genome-Wide-DNA-Methylation-Profiling-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,3,19]]},"published-print":{"date-parts":[[2021,5,15]]}},"URL":"https:\/\/doi.org\/10.1158\/0008-5472.can-20-3445","relation":{"has-preprint":[{"id-type":"doi","id":"10.1158\/0008-5472.c.6512658.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22427403.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.c.6512658","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22427406","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22427403","asserted-by":"object"},{"id-type":"doi","id":"10.1158\/0008-5472.22427406.v1","asserted-by":"object"}]},"ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]}}}