{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T09:40:49Z","timestamp":1656582049711},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"24_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The randomised controlled TARGeted Intraoperative radioTherapy (TARGIT) Trial has demonstrated non-inferiority between the novel technique of TARGIT (intra-operative radiotherapy with Intrabeam \u00ae) and conventional whole-breast external beam radiotherapy (EBRT) in women with early breast cancer, in terms of the primary outcome measure of risk of local relapse within the treated breast. As there are very low recurrence rates, cosmesis becomes an increasingly important outcome of breast conserving treatment with both surgery and radiotherapy. This study was performed to determine if the single high dose of TARGIT compared with EBRT leads to impaired cosmesis.<\/jats:p>\n               <jats:p>A validated, objective assessment software tool for evaluation of cosmetic outcome was used. Frontal digital photographs were taken at baseline (before radiotherapy) and annually thereafter for up to five years. The photographs were analysed by BCCT.core which produces a composite score based on symmetry, colour and scar.<\/jats:p>\n               <jats:p>A total of 342 patients were assessed, all over 50 years old with a median age at baseline of 64 years (IQR 59 to 68). The BCCT.core scores were dichotomised into Excellent and Good (EG), and Fair and Poor (FP). There were statistically significant increases in the odds of having an outcome of EG for patients in the TARGIT group compared with the EBRT group at year 1 (OR = 2.07, 95%CI 1.12 to 3.85, p = 0.021) and year 2 (OR = 2.11, 95%CI 1.0 to 4.45, p = 0.05).<\/jats:p>\n               <jats:p>This objective assessment of aesthetic outcome in patients from a randomised setting demonstrates that those treated with targeted intraoperative radiotherapy have a superior cosmetic result compared with those patients who received conventional whole-breast external beam radiotherapy.<\/jats:p>\n               <jats:p>Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-14-12.<\/jats:p>","DOI":"10.1158\/0008-5472.sabcs13-p5-14-12","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T22:26:43Z","timestamp":1408055203000},"page":"P5-14-12-P5-14-12","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract P5-14-12: Cosmetic outcome is better after intraoperative radiotherapy compared with external beam radiotherapy: An objective assessment of patients from a randomized controlled trial"],"prefix":"10.1158","volume":"73","author":[{"given":"M","family":"Keshtgar","sequence":"first","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"NR","family":"Williams","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"T","family":"Corica","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"M","family":"Bulsara","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"C","family":"Saunders","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"H","family":"Flyger","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"N","family":"Bentzon","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"JS","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"N","family":"Michalopoulos","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]},{"given":"DJ","family":"Joseph","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom; UCL, London, United Kingdom; Sir Charles Gairdner Hospital, Perth, Australia; University of Notre Dame, Fremantle, Australia; Herlev Hospital, Copenhagen, Denmark; University of Porto, Porto, Portugal"}]}],"member":"1086","container-title":["Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P5-14-12\/586012\/Abstract-P5-14-12-Cosmetic-outcome-is-better-after","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P5-14-12\/586012\/Abstract-P5-14-12-Cosmetic-outcome-is-better-after","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T09:15:11Z","timestamp":1656580511000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P5-14-12\/586012\/Abstract-P5-14-12-Cosmetic-outcome-is-better-after"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,15]]},"references-count":0,"journal-issue":{"issue":"24_Supplement","published-print":{"date-parts":[[2013,12,15]]}},"URL":"https:\/\/doi.org\/10.1158\/0008-5472.sabcs13-p5-14-12","relation":{},"ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,15]]}}}